An interventional study of Ciprofloxacin Oral Product in Epilepsy Intractable, sponsored by Mazandaran University of Medical Sciences. Completed at 1 site in Iran. Open to participants aged 16 Years to 50 Years. Per ClinicalTrials.gov, last updated 2021-06-07.
Sponsored by Mazandaran University of Medical Sciences · Not applicable, Interventional, and Treatment
This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.
270 studies on the registry are indexed under Drug Resistant Epilepsy; 100 are open to participants now.
This study's enrollment of 23 is below the median of 30 across 213 interventional studies indexed under Drug Resistant Epilepsy.
Browse Drug Resistant Epilepsy studies →Mazandaran University of Medical Sciences is the lead sponsor of 22 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
Drug: Ciprofloxacin Oral Product
The first stool sample will be taken before treatment and the second one will be taken in day 5 to 7 after treatment initiation. Treatment includes ciprofloxacin tablet 500mg twice a day for 5 days.
Changes in seizure frequency registered in questionnaire
Comparison of seizure frequency in 4th week with the frequency at the start of the study.
Time frame: 4 weeks
Changes in quantity of microbial DNA extracted from stool samples by AccuPrep Stool DNA extraction Kit
Comparison of quantity of extracted microbial DNA in stool sample taken at day5-7 with the sample taken at the start of the study
Time frame: 7 days
Changes in microbial burden of stool samples using Absolute real time polymerase chain reaction (PCR)
Comparison of microbial burden of stool samples taken at day5-7 with the sample taken at the start of the study
Time frame: 7 days
Changes in seizure frequency registered in questionnaire
Comparison of seizure frequency in 12th week with the frequency at the start of the study
Time frame: 12 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2021. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Ciprofloxacin
Mazandaran University of Medical Sciences