Arrhythmogenic Right Ventricular Dysplasia clinical trials
The registry lists 48 studies for Arrhythmogenic Right Ventricular Dysplasia across more than 10 countries. 28 are recruiting or about to start. 23 of them are mainly about Arrhythmogenic Right Ventricular Dysplasia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
University of British Columbia (4) · Lexeo Therapeutics (3) · Rocket Pharmaceuticals Inc. (2) · University Hospital, Toulouse (2) · Tenaya Therapeutics (2) · Beijing Institute of Heart, Lung and Blood Vessel Diseases (2) · London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's (1) · Heidelberg University (1)
What is being tested here
Drugs under test in Arrhythmogenic Right Ventricular Dysplasia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tideglusib | 1 | 0 | 1 |
| Spironolactone | 1 | 0 | 1 |
| Atibuclimab | 0 | 0 | 1 |
| Flecainide | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Dec 2026Gene Therapy for ACM Due to a PKP2 Pathogenic Variant · Lexeo Therapeutics
- Feb 2027Local Inflammation in Arrhythmogenic Right Ventricular Cardiomyopathy · University Hospital, Toulouse
- Feb 2027Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy · Hamilton Health Sciences Corporation
- Mar 2027Mayo AVC Registry and Biobank · Mayo Clinic
- Jul 2027A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM · Lexeo Therapeutics
Who these studies take
Of the 20 Arrhythmogenic Right Ventricular Dysplasia studies recruiting now, 14 (70%) set no upper age limit and 4 (20%) stop at 75 or younger. 8 (40%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (20%) | 4 (20%) |
| 18 | 20 (100%) | 20 (100%) |
| 30 | 20 (100%) | 20 (100%) |
| 40 | 19 (95%) | 19 (95%) |
| 50 | 19 (95%) | 19 (95%) |
| 65 | 19 (95%) | 19 (95%) |
| 75 | 16 (80%) | 16 (80%) |
| 85 | 15 (75%) | 15 (75%) |
Across all 48 studies, recruiting or not: 23% stop at 75 or younger and 17% at 65; 46% take children; 0% are for women only and 0% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Athlete's Heart or Arrhythmogenic Right Ventricular Cardiomyopathy: Contribution of Exercise Cardiovascular Magnetic Resonance (CMR)TerminatedOct 15, 2026NCT05024708
Newly registered1
- Focal Pulsed Field Ablation of Ventricular TachycardiaNov 10, 2026NCT07929545
Studies
Recruiting first, then most recently updated. Showing 48 of 48. search them.
- Focal Pulsed Field Ablation of Ventricular TachycardiaEnrolling by invitationNCT079295451 country
- PKP2-ACM Natural History StudyRecruitingNCT066447422 countries
- Cardiovascular Multimodality Imaging StudyRecruitingNCT066100191 country
- Cardiac Rehabilitation in Patients With High-Genetic-Risk Arrhythmogenic Cardiomyopathy: The HGEN-CARE-AC TrialNot yet recruitingNCT07708311Not applicable
- Treatment Registry of Arrhythmias, Complications and Electrocardiograms in Arrhythmogenic CardioMyopathiesNot yet recruitingNCT07688200
- Pediatric Cardiomyopathy Mutation AnalysisRecruitingNCT024320921 country
- Local Inflammation in Arrhythmogenic Right Ventricular CardiomyopathyRecruitingNCT05209776Not applicable1 country
- National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter RegistryRecruitingNCT065461371 country
- Distribution of Cell-cell Junction Proteins in Arrhythmic DisordersRecruitingNCT042579941 country
- FAPI PET/CT Imaging in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (FAPI-ARVC))RecruitingNCT07563660Not applicable1 country
- Mayo AVC Registry and BiobankRecruitingNCT030492542 countries
- A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)RecruitingNCT05885412Phase 11 country
- Arrhythmogenic Activity During Exercise in ARVC PatientsRecruitingNCT06040242Not applicable1 country
- Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic CardiomyopathyRecruitingNCT06174220Phase 21 country
- Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVDRecruitingNCT03593317Phase 21 country
- Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac ArrhythmiasEnrolling by invitationNCT024134501 country
- Long-term Follow-up Study of Gene Therapy for Arrhythmogenic Cardiomyopathy Due to a Plakophilin-2 Pathogenic VariantEnrolling by invitationNCT070501601 country
- A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACMRecruitingNCT069766061 country
- Clinical Cohort Study - TRUSTRecruitingNCT055214511 country
- Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults with PKP2 Mutation-associated ARVCRecruitingNCT06228924Phase 11 country
- AI-enabled Screening and Diagnosis of Cardiomyopathies Using Coronary CTANot yet recruitingNCT06748261
- Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)RecruitingNCT063117086 countries
- Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.RecruitingNCT066074711 country
- DZHK TORCH-Plus is a Registry for Patients With Cardiomyopathies and Serves as Source for Cardiovascular Research StudiesRecruitingNCT042650401 country
- Low QRS Voltages in Young Healthy Individuals and AthletesRecruitingNCT057998331 country
- Hearts in Rhythm Organization (HiRO)National Registry and Bio BankEnrolling by invitationNCT041898221 country
- China Structural Ventricular Arrhythmias RegistryRecruitingNCT038210511 country
- Sahlgrenska Cardiomyopathy ProjectEnrolling by invitationNCT035273421 country
- Athlete's Heart or Arrhythmogenic Right Ventricular Cardiomyopathy: Contribution of Exercise Cardiovascular Magnetic Resonance (CMR)TerminatedNCT05024708Not applicable1 country
- Healthy-related Quality of Life and Physical Activity of Children With Cardiac MalformationsCompletedNCT04712136Not applicable1 country
- DNA Analysis From Isolated Cardiomyocytes in the Molecular Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/DysplasiaCompletedNCT03177018Not applicable1 country
- IC14 (Atibuclimab) in Arrhythmogenic CardiomyopathyCompletedNCT06275893Phase 1/21 country
- Gene Therapy for ACM Due to a PKP2 Pathogenic VariantActive, not recruitingNCT06109181Phase 1/21 country
- Pilot Randomized Trial With Flecainide in ARVC PatientsCompletedNCT03685149Phase 21 country
- South Asian Arrhythmogenic Cardiomyopathy RegistryStatus unknownNCT048955402 countries
- National ARVC Data Registry and Bio BankCompletedNCT018046991 country
- Registry of Unexplained Cardiac ArrestCompletedNCT002920321 country
- Long Term Monitoring for Risk of Sudden DeathCompletedNCT041242371 country
- Diagnostic Value and Safety of Flecainide Infusion Test in Brugada SyndromeCompletedNCT023022741 country
- PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVCStatus unknownNCT029894801 country
- Risk Stratification in Children and Adolescents With Primary CardiomyopathyStatus unknownNCT035725691 country
- An Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in ChinaStatus unknownNCT030765801 country
- Metabolomic Study of All-age CardiomyopathyStatus unknownNCT030619941 country
- The Role of High Density Surface ECG in the Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)CompletedNCT02291393Not applicable
- Prolonged Monitoring to Detect Ventricular Arrhythmias in Presymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) PatientsTerminatedNCT012718161 country
- Arrhythmogenic Right Ventricular Dysplasia/CardiomyopathyCompletedNCT009999471 country
- Multidisciplinary Study of Right Ventricular DysplasiaCompletedNCT000245051 country
- Molecular Genetic Screening and Identification of Congenital Arrhythmogenic DiseasesStatus unknownNCT002218321 country