Arnold-Chiari Malformation clinical trials
The registry lists 34 studies for Arnold-Chiari Malformation across more than 10 countries. 10 are recruiting or about to start. 21 of them are mainly about Arnold-Chiari Malformation (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Assistance Publique - Hôpitaux de Paris (3) · National Institute of Neurological Disorders and Stroke (NINDS) (3) · University Hospital, Bordeaux (2) · Kent State University (2) · Hacettepe University (2) · St. Joseph's Hospital and Medical Center, Phoenix (1) · Johns Hopkins University (1) · Central Hospital, Nancy, France (1)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Nov 2026Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey · Karolinska Institutet
- Dec 2026Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction Anomalies · University of Michigan
- Apr 2027Fetoscopic Repair of Isolated Fetal Spina Bifida · Johns Hopkins University
Who these studies take
Of the 4 Arnold-Chiari Malformation studies recruiting now, 2 (50%) set no upper age limit and 2 (50%) stop at 75 or younger. 1 (25%) take children under 18. 1 (25%) are for women only and 0 (0%) for men only; 1 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 4 (100%) | 3 (75%) |
| 30 | 4 (100%) | 3 (75%) |
| 40 | 4 (100%) | 3 (75%) |
| 50 | 4 (100%) | 3 (75%) |
| 65 | 3 (75%) | 2 (50%) |
| 75 | 2 (50%) | 1 (25%) |
| 85 | 2 (50%) | 1 (25%) |
Across all 34 studies, recruiting or not: 47% stop at 75 or younger and 44% at 65; 41% take children; 15% are for women only and 3% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Arnold-Chiari Malformation studies take
Of 16 interventional studies with no phase under Arnold-Chiari Malformation, half reached primary completion within 25 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 25 mo10–59 · 16 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 34 of 34. search them.
- Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient SurveyEnrolling by invitationNCT078181221 country
- Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari MalformationsRecruitingNCT06502431Not applicable1 country
- Abnormality of the Central Canal of the Spinal Cord in Syringomyelia in a Patient With a Basal Skull MalformationNot yet recruitingNCT07720206Not applicable1 country
- Dynamic MRI and Quantitative MR CSF Flow Studies in Craniovertebral Junction AnomaliesEnrolling by invitationNCT00795080
- The Role of CSF in Chiari II Brain MalformationNot yet recruitingNCT06560788
- Development of a Patient-reported Outcome Measure for Chiari Malformation and SyringomyeliaNot yet recruitingNCT060112261 country
- A New Approach in Intensive Care Unit Consciousness Assessment: FIVE ScoreNot yet recruitingNCT060367321 country
- Modalities of Surgical Treatment of Chiari Malformation Disease : Clinical Study and OutcomesRecruitingNCT06029101Not applicable1 country
- Investigation of the Effects of Exercise Program in Patients With Chiari Type 1 MalformationRecruitingNCT04073667Not applicable1 country
- Laparotomy Versus Percutaneous Endoscopic Correction of MyelomeningoceleRecruitingNCT03856034Not applicable1 country
- Genetic Analysis of the Chiari I MalformationCompletedNCT000047382 countries
- MiDura-Study (Neuro-Patch in Duraplasty)CompletedNCT041891722 countries
- A Prospective Natural History Study of Patients With SyringomyeliaCompletedNCT011507081 country
- Clinical Study of the Treatment of Chiari Malformation Combined With Type II Skull Base DepressionCompletedNCT05754554Not applicable1 country
- Fetoscopic Repair of Isolated Fetal Spina BifidaActive, not recruitingNCT03090633Not applicable1 country
- Identification of Genetic Mutations Involved in Chiari Type I MalformationsCompletedNCT05165030Not applicable1 country
- PFDD Versus PFDRT in Chiari Decompression SurgeryCompletedNCT06079125Not applicable1 country
- Prenatal Surgical Repair of Fetal MyelomeningoceleCompletedNCT01983345Not applicable1 country
- Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With SyringomyeliaCompletedNCT02669836Not applicable1 country
- Examining Different Components of Online Acceptance and Commitment Therapy for People With Chiari MalformationActive, not recruitingNCT05581472Not applicable1 country
- Arnold Chiari Malformation: the Otological Assessment as an Objective Criteria for Surgical TreatmentCompletedNCT03295864Not applicable1 country
- Dural Graft Equivalent Comparison TrialCompletedNCT01667770Not applicable1 country
- Efficacy of Acetaminophen in Posterior Fossa SurgeryWithdrawnNCT02532322Phase 21 country
- Investigation of the Effects of Exercise on Patients With Chiari MalformationCompletedNCT04220541Not applicable1 country
- Online Acceptance and Commitment Therapy for Chronic Pain in Sample of People With Chiari MalformationCompletedNCT04089670Not applicable1 country
- Postual Control in Pediatric Chiari I MalformationStatus unknownNCT046797921 country
- Fetoscopic Open Spina Bifida Repair Using the SAFER TechniqueCompletedNCT043567031 country
- The Genetics of Chiari Type I MalformationCompletedNCT010608001 country
- An Audit of the Posterior Fossa Characterization in Open Spina Bifida Based on Tertiary Center ExperienceCompletedNCT035449701 country
- Fetal Endoscopic Surgery for Spina BifidaStatus unknownNCT03315637Not applicable1 country
- Establishing the Physiology of SyringomyeliaCompletedNCT000013271 country
- Comparison of Four Questionnaires for OSA Screening in ChinaStatus unknownNCT03074747
- Magnetic Resonance Imaging of the SpineWithdrawnNCT01382290Not applicable1 country
- Duragen Versus Duraguard in Chiari SurgeryCompletedNCT00741858Phase 31 country