An interventional study of Treadmill-integrated virtual reality gait training in Multiple Sclerosis, sponsored by Shepherd Center, Atlanta GA. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by Shepherd Center, Atlanta GA · Not applicable, Interventional, and Treatment
This study will test whether a treadmill-based virtual reality walking program is safe, practical, and helpful for people with multiple sclerosis (MS). Participants will complete a 6-week training program and wear smart socks that measure how they walk before, during, and after the program. The study will also track changes in balance, fatigue, fall risk, fear of falling, confidence with walking, and overall quality of life.
People with multiple sclerosis (MS) often have trouble with walking and balance, which can increase the risk of falls and make daily life harder. While therapy can improve walking in a clinic, it is not always clear if those improvements carry over to real life at home or in the community. In addition, most walking tests are done over short periods and may not show how a person moves throughout the day. This study will look at new ways to better understand and improve walking in everyday settings. Researchers will use a treadmill-based virtual reality program, along with smart socks that track walking during daily activities. This approach will help show how people respond to training and whether those changes last outside the clinic. Standard care for people with MS usually includes physical therapy and clinic-based walking tests, but these may miss important changes in daily movement.
Participants will be asked to provide basic health information and complete surveys about their walking, fatigue, balance, thinking, and quality of life at different times during the study. They will also complete simple walking and balance tests to measure their mobility. As part of the study, participants will take part in a 6-week treadmill-based virtual reality training program, with two sessions each week. During the study, they will wear smart socks that collect information about how they walk in their daily lives, including before, during, and after the training program. These socks will track how often they walk, how steady they are, and how their walking changes over time. After the training ends, participants will continue wearing the socks for several weeks so researchers can see if improvements last. The results will help researchers learn if this approach can improve walking, lower fall risk, and support better mobility and quality of life for people living with MS.
3,264 studies on the registry are indexed under Multiple Sclerosis; 659 are open to participants now.
This study's planned enrollment of 10 is below the median of 50 across 2,201 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →Shepherd Center, Atlanta GA is the lead sponsor of 22 studies on the registry; 4 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Gait training
Other: Treadmill-integrated virtual reality gait training
6-week training program with 2 training sessions each week
Spatiotemporal metrics of gait
step length (m)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
stride length (m)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
step time (s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
single support time (s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
double support time (s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
gait cycle (s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
cadence (steps/s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
stance time (s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
speed(m/s)
Time frame: Initial visit to the end of the program in 12 weeks
Spatiotemporal metrics of gait
swing time (s)
Time frame: Initial visit to the end of the program in 12 weeks
Fear of falling (FOF)
FOF as determined by Falls Efficacy Scale-International (FES-I); Scale: Not at all concerned = 1, Somewhat concerned = 2, Fairly concerned = 3, Very concerned = 4; Lowest score = 16, Highest score = 64, lower scores indicated less FOF (better), higher scores indicated more FOF (worse), total score divided by 64.
Time frame: Surveys will be conducted at the initial visit, week 2, 5, 8, and 12.
Plan to share: No — Shepherd Center will publish findings as appropriate and will maintain confidential records as necessary.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Shepherd Center, Atlanta GA