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Enrolling by invitationNCT07915193Updated Nov 4, 2026

Application of Generative Artificial Intelligence in Perioperative Personalized Rehabilitation for Older Adults With Lung Cancer

An interventional study of AI-guided personalized rehabilitation in Lung Neoplasms, sponsored by Peking University Cancer Hospital & Institute. Enrolling by invitation at 1 site in China. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-11-04.

Sponsored by Peking University Cancer Hospital & Institute · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Registered 1 year 11 months after the study started (first participant enrolled Oct 2024, registered Sep 2026).
Updated Nov 4, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
150
Allocation
Randomized
Ages
65 Years and older
Sex
All
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Study summary

This study will evaluate whether a generative artificial intelligence (AI)-based rehabilitation support system can help older adults with lung cancer recover after lung surgery. Eligible participants aged 65 years or older who are scheduled for video-assisted thoracoscopic surgery (VATS) will be randomly assigned to receive either personalized perioperative rehabilitation guidance through the AI-based system or usual rehabilitation guidance. The system will provide guidance on exercise, nutrition, and psychological well-being before surgery and during recovery, and participants may report symptoms for follow-up guidance. The study will compare lung function and quality of life between the groups. It will also assess exercise tolerance, emergency department visits, hospital readmissions, and events related to use of the system.

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Conditions studied

  • Lung Neoplasms

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03

In context

Lung Neoplasms

7,343 studies on the registry are indexed under Lung Neoplasms; 1,562 are open to participants now.

This study's planned enrollment of 150 is above the median of 60 across 5,348 interventional studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

Peking University Cancer Hospital & Institute is the lead sponsor of 268 studies on the registry; 129 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age 65 years or older.
  2. Scheduled to undergo video-assisted thoracoscopic surgery (VATS) for lung tumor resection.
  3. Able to walk and exercise, complete follow-up, and undergo pulmonary function testing.
  4. Able to communicate with the study team and complete questionnaires.

Exclusion criteria

Exclusion Criteria:

  1. Unable to walk or perform functional exercise because of a physical condition.
  2. Unable to complete pulmonary function testing because of a physical condition.
  3. Expected to live outside the area after surgery and unable to return for scheduled follow-up.
  4. Any other reason the investigator considers the person unsuitable for participation.
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Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
150 participants (estimated)

Study arms

  • Experimental
    AI-guided personalized rehabilitation

    Behavioral: AI-guided personalized rehabilitation

  • No intervention
    Usual care rehabilitation guidance

Interventions

  • BehavioralAI-guided personalized rehabilitation

    Participants will use a mobile-based generative AI rehabilitation support system before and after surgery. Before surgery, the system will provide daily reminders and personalized guidance for home-based exercise and provide support related to nutrition and psychological well-being. After surgery, participants will report relevant symptoms, such as pain, shortness of breath, cough, or fever, and receive interactive rehabilitation guidance adjusted according to their reported condition. The system is supervised by the clinical team.

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What researchers measure

Primary outcomes

  1. MDASI-LC quality-of-life scores

    Quality of life will be assessed using the MD Anderson Symptom Inventory for Lung Cancer (MDASI-LC), including 6 items on symptom interference with daily life and 16 items measuring symptom severity. The scores will be collected using an online questionnaire.

    Time frame: Before surgery; 1 week and 2 weeks after hospital discharge; and at the 1-month postoperative return visit

  2. Forced Expiratory Volume in 1 Second (FEV1)

    FEV1 will be measured using a handheld spirometer.

    Time frame: Before surgery, on the day of hospital discharge, and at the 1-month postoperative return visit

  3. Forced Vital Capacity (FVC)

    FVC will be measured using a handheld spirometer.

    Time frame: Before surgery; on the day of hospital discharge; and at the 1-month postoperative return visit.

  4. Maximum Voluntary Ventilation (MVV)

    MVV will be measured using a handheld spirometer.

    Time frame: Before surgery; on the day of hospital discharge; and at the 1-month postoperative return visit.

Secondary outcomes

  1. Borg Rating of Perceived Exertion During Aerobic Exercise

    Perceived exertion during aerobic exercise will be assessed using the Borg Rating of Perceived Exertion (RPE) Scale. Scores range from 6 to 20, with higher scores indicating greater perceived exertion.

    Time frame: Before surgery and at postoperative weeks 1, 2, 3, and 4.

  2. Emergency Department Visits

    'The number of participants with an emergency department visit will be recorded.

    Time frame: From randomization through 24 months after surgery.

  3. Hospital Readmissions

    The number of participants readmitted to the hospital will be recorded.

    Time frame: From randomization through 24 months after surgery.

  4. Adverse Events Related to the AI-Based Rehabilitation System

    The number of participants experiencing adverse events related to use of the system will be recorded, including injuries associated with excessive exercise, falls, eye strain, or other harm related to system use.

    Time frame: From first use of the system through 24 months after surgery.

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Study locations

1 site
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Nov 4, 2026
Show all 1 update
  1. Nov 4, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07915193
Responsible party
Sponsor
First posted
Nov 4, 2026
Start date
Oct 9, 2024
Primary completion
Dec 31, 2026 (estimated)
Completion
Jun 30, 2027 (estimated)
Last update
Nov 4, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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