Revascularization of Immature Teeth With Our Different Scaffolds

Browse trials for

• Thrombosis 955

Keywords

• Blood clot, Collagen membrane, Cone beam computed tomography, Platelet rich fibrin, Platelet rich plasma, Scaffold

Thrombosis

955 studies on the registry are indexed under Thrombosis; 171 are open to participants now.

This study's enrollment of 40 is below the median of 83 across 530 interventional studies indexed under Thrombosis.

Lead sponsor

Tanta University is the lead sponsor of 1,010 studies on the registry; 321 are open to participants now.

Of its 15 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Study arms

• Active comparator
  Group I

  For Blood Clot scaffold group, intracanal bleeding was intentionally induced by gently extending a sterile #40 stainless-steel K-file 1-2 mm beyond the apical foramen into the periapical tissues. Bleeding was allowed to reach at least 3 mm below the level of the CEJ, any excess blood above the CEJ coronally was removed with a suitable size of sterile paper points. After waiting nearly 10 minutes, the integrity of the newly formed clot was detected using a suitable sterile paper point

  Other: Blood Clot

• Active comparator
  Group II

  For PRP group, 5 mL of peripheral venous blood was obtained from the antecubital vein of each patient by venipuncture and collected into a 10 mL sterile glass tube containing acid citrate dextrose as an anticoagulant. The blood sample was initially centrifuged at 2400 rpm for 10 minutes to separate PRP and platelet-poor plasma (PPP) from the erythrocyte fraction. Following the first centrifugation cycle, three distinct layers were observed within the tube.; a bottom red thick layer containing red blood cells, a central buffy lightly yellowish layer containing white blood cells and plasma cells, and a supernatant turbid liquid layer which is acellular plasma. Supernatant layer (PRP + PPP) was carefully transferred to a sterile tube and subjected to a second centrifugation at 3600 rpm for 15 minutes to further separate the PRP from the PPP. After the second centrifugation cycle, PRP precipitated at the bottom of the tube as light yellowish slimy viscous substance which was retri

  Other: Platelet Rich Plasma

• Active comparator
  Group III

  For PRF group, 5 mL of the own venous blood was collected from the patient arm then was placed in a sterile tube without anticoagulant and centrifuged immediately at 3000 rpm for 10 minutes using a centrifuge machine . Three layers were formed inside each tube: a base layer containing erythrocytes, an intermediate layer of PRF clot, and a surface layer of acellular plasma. The PRF clot was removed from the test tube with sterile cotton plier and then put on a sterile gauze then cleared from the base erythrocyte layer using sterile scissor. The freshly prepared PRF clot was compressed between two sterile gauze pieces to form a membrane. The freshly prepared PRF membrane was sectioned into small fragments using sterile #15 scalpel blade and was placed incrementally inside root canal till the full WL length and nearly up to 3 mm below the level of the CEJ. A sterile hand plugger of appropriate size, adjusted to a length 2-3 mm shorter than the WL, was used to facilitate controlled place

  Other: Platelet Rich Fibrin

• Active comparator
  Group IV

  The collagen membrane scaffold, supplied in a 15 × 20 mm dimension was cut into small pieces using #15 sterile scalpel blade, The resulting collagen fragments were then introduced incrementally into the root canal and gently compacted using the same technique described previously for placement of the PRF scaffold

  Other: Collagen Membrane

Interventions

• OtherBlood Clot

  regenerative endodontic treatment using blood clot as scaffold

• OtherPlatelet Rich Plasma

  regenerative endodontic treatment using platelet rich plasma as scaffold

• OtherPlatelet Rich Fibrin

  regenerative endodontic treatment using platelet rich fibrin as scaffold

• OtherCollagen Membrane

  regenerative endodontic treatment using collagen membrane as scaffold

Primary outcomes

1. changing in root length

   Time frame: 1 year

2. changing in periapical lesion size

   Time frame: 1 year

Individual participant data

Plan to share: No