An observational study in Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity and Compartment Syndrome Traumatic Upper Extremity, sponsored by Ukrainian Society of Regional Anesthesia and Pain Therapy. Not yet recruiting at 1 site in Ukraine. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-11-02.
Sponsored by Ukrainian Society of Regional Anesthesia and Pain Therapy · Observational
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect multiple body areas and whether they occur at the same time or one after another. Researchers will examine records for signs involving the abdomen, chest, limbs, or head, and explore how these findings relate to injury severity, resuscitation, organ function, and patient outcomes. No treatment will be assigned as part of this study, and patient care will not be changed.
Polycompartment syndrome (PCS) refers to pressure-related dysfunction involving two or more anatomical compartments, either at the same time or in sequence. In severe blast trauma, direct tissue injury, hemorrhage, fractures, burns, swelling, and resuscitation may affect several regions. Assessing each region in isolation may not capture how these problems develop together or relate to organ dysfunction.
This retrospective cohort will use existing clinical records to describe compartment-related findings in patients treated for blast-related injuries. The review will consider documented assessments of the abdomen, thorax, extremities, and head, including pressure measurements when available, their timing, and associated organ dysfunction. It will also examine recorded injury characteristics, resuscitation, management, and clinical outcomes to identify patterns and associations.
Each region will be evaluated using its own clinical assessment criteria. Findings in one compartment will not, by themselves, be treated as evidence of dysfunction in another. The study will describe how often multiple compartments are involved and whether documented involvement is concurrent or sequential. Because this is a retrospective review, the analyses will depend on the completeness and consistency of information in the medical records.
52 studies on the registry are indexed under Compartment Syndromes; 8 are open to participants now.
This study's planned enrollment of 100 is above the median of 85 across 20 observational studies indexed under Compartment Syndromes.
Browse Compartment Syndromes studies →Ukrainian Society of Regional Anesthesia and Pain Therapy is the lead sponsor of 15 studies on the registry; 9 are open to participants now.
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Patients with combat-related blast injuries treated at the participating study site(s) during the study period will form the source population. The cohort will include patients with and without documented polycompartment syndrome, allowing the frequency and pattern of compartment involvement to be described. The study population will be identified from existing medical records for the index hospitalization.
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Exclusion Criteria:
Participants in this cohort are patients treated for blast-related trauma whose existing medical records will be reviewed for documented involvement of multiple anatomical compartments. Exposures of interest include injury characteristics, compartment-specific findings, and resuscitation documented during routine care. No intervention is assigned by the study.
Proportion of Patients With Polycompartment Syndrome
Number and percentage of patients meeting the study's prespecified definition of compartment syndrome or pressure-related dysfunction in two or more anatomical compartments (abdomen, thorax, cranium, and/or extremity). Cases will be classified as concurrent or sequential when timing is documented.
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Distribution of Affected Anatomical Compartments
Frequency and percentage of patients with abdominal, thoracic, cranial, or extremity involvement, including documented combinations.
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Timing and Sequence of Compartment Involvement
Proportion of cases with simultaneous versus sequential involvement and, where documented, the time between the first and subsequent compartment involvement.
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
In-Hospital Clinical Outcomes
In-hospital clinical outcomes will be obtained from the medical record and reported separately. These will include in-hospital mortality, hospital length of stay, ICU admission and ICU length of stay, need for mechanical ventilation, and documented complications.
Time frame: From admission for the index blast injury; assessed at admission and during the first 3 hours, with in-hospital follow-up through Day 7 or until hospital discharge or in-hospital death, whichever occurs first
Plan to share: No — No individual participant data will be shared. This retrospective study involves sensitive health information related to combat injuries. Only aggregate, non-identifiable findings will be reported.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Ukrainian Society of Regional Anesthesia and Pain Therapy