An observational study in Combat-Related Limb Injury, Nerve Block and Nerve Damage, sponsored by Ukrainian Society of Regional Anesthesia and Pain Therapy. Not yet recruiting. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-10-09.
Sponsored by Ukrainian Society of Regional Anesthesia and Pain Therapy · Observational
This study will examine nerve problems after combat-related injuries to the arms or legs. Some patients receive a peripheral nerve block, an injection of local anaesthetic near a nerve, to help control pain. However, combat injuries themselves can damage nerves through blast effects, fractures, blood vessel injury, bleeding, infection, surgery, or use of a tourniquet.
The study will follow adults with combat-related limb injuries who receive routine care at a specialised trauma centre. Treatment will not be assigned by the study. Researchers will record details of the injury, pain treatment, nerve block use, and nerve function over time.
The main goal is to determine how often patients have new or worsened numbness, weakness, or nerve pain after injury, and whether these problems are more closely related to the injury itself, the nerve block, or several factors together. The findings may help clinicians provide safer pain treatment and recognise nerve problems earlier.
Combat-related limb trauma is frequently accompanied by peripheral nerve injury. Neurological symptoms identified after trauma may result from the original injury, blast effects, fractures, vascular compromise, tourniquet exposure, haematoma, infection, surgery, or pain treatment. Peripheral nerve blocks are commonly used for analgesia, but determining whether a later neurological deficit is related to the block, the injury, or multiple factors is often difficult.
This prospective observational cohort study will collect routine clinical data from adults with combat-related upper- or lower-limb trauma. The study will not assign or alter treatment. Peripheral nerve blocks, surgical care, imaging, rehabilitation, and pharmacological analgesia will be provided according to clinical need and local practice.
Investigators will document injury characteristics, neurological findings before and after analgesia when feasible, regional anaesthesia details, pain outcomes, relevant imaging and follow-up neurological status. Participants with a persistent or worsening neurological deficit will undergo structured multidisciplinary case review. Events will be classified as trauma-associated, possibly block-associated, multifactorial, or indeterminate.
The study aims to describe neurological outcomes after combat limb trauma and identify factors associated with persistent deficits. The findings may support safer regional anaesthesia practice, improve documentation of baseline nerve function, and strengthen pathways for early recognition and referral of peripheral nerve injury.
91 studies on the registry are indexed under Peripheral Nerve Injuries; 22 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 66 across 24 observational studies indexed under Peripheral Nerve Injuries.
Browse Peripheral Nerve Injuries studies →Ukrainian Society of Regional Anesthesia and Pain Therapy is the lead sponsor of 14 studies on the registry; 9 are open to participants now.
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Adults with combat-related upper- or lower-limb trauma treated at a specialised Ukrainian war trauma centre. The population includes patients with blast- or ballistic-related injuries, fractures, soft-tissue injury, vascular injury, traumatic amputation, or complex reconstructive needs. Patients may receive ultrasound-guided peripheral nerve blocks or routine non-regional analgesia as part of standard clinical care.
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Exclusion Criteria:
Adults with combat-related upper- or lower-limb trauma who received an ultrasound-guided peripheral nerve block as part of routine clinical care. Blocks may be single-injection techniques or continuous peripheral nerve catheters. The study does not assign the block or modify clinical treatment; it records routinely delivered analgesia and subsequent neurological outcomes.
Number of participants with persistent peripheral neurological deficit at 90 days after injury
Persistent peripheral neurological deficit will be assessed at 90 days after injury by clinical neurological examination and documented as present or absent, including sensory loss, motor weakness, or neuropathic symptoms attributable to peripheral nerve injury.
Time frame: Mean Medical Research Council (MRC) muscle strength score at 90 days after injury
Number of participants with early peripheral neurological deficit within 72 hours after injury
Early peripheral neurological deficit will be assessed within 72 hours after injury by clinical neurological examination and recorded as present or absent. Deficit includes sensory loss, motor weakness, or neuropathic symptoms consistent with peripheral nerve injury.
Time frame: 48 to 72 hours after the index injury.
Pain Intensity
Pain intensity at rest and during movement measured on the 0-10 Numeric Rating Scale.
Time frame: 48 to 72 hours and 90 days after the index injury.
Attribution of Persistent Neurological Deficit
Multidisciplinary classification of persistent neurological deficits as trauma-associated, possibly peripheral nerve block-associated, multifactorial, or indeterminate.
Time frame: 90 days after the index injury.
Number of participants with a regional anaesthesia-related safety event within 48 hours after block placement
Regional anaesthesia-related safety events will be recorded from block placement until 48 hours afterwards and reported as present or absent. Events include local anaesthetic systemic toxicity, clinically significant bleeding or haematoma, infection, persistent paraesthesia or motor deficit, nerve injury, vascular puncture, pneumothorax, or unplanned escalation of care attributable to the procedure.
Time frame: From peripheral nerve block placement to 72 hours after the index injury.
No study locations are listed for this record.
Plan to share: No — Individual participant data will not be shared because the study includes sensitive clinical and conflict-related information. Protecting participant confidentiality and operational security is essential. De-identified aggregate results may be available in publications and, where appropriate, further information may be considered after ethics and data-governance review.
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Oct 2026, 0 months later.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Ukrainian Society of Regional Anesthesia and Pain Therapy