An interventional study of sensorimotor training with TACS and sensorimotor training with Sham TACS in Sub-acute Stroke, sponsored by University of Management and Technology Lahore. Active, not recruiting at 1 site in Pakistan. Open to participants aged 45 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by University of Management and Technology Lahore · Not applicable, Interventional, and Treatment
Stroke is leading cause of death and disability worldwide, resulting in significant functional limitations and disabilities experienced by stroke survivors. Stroke is an umbrella term that includes disorders such as cerebral infarction, cerebral hemorrhage, and subarachnoid hemorrhage.The aim of this study will be to compare the effects of sensorimotor training and transcranial alternating current stimulation on upper extremity functions, sensorimotor impairment and cervical joint position sense in sub-acute stroke patients.
A single blinded randomized clinical trial will be used. Allocation will be concealed by sealed envelope. Non- probability convenient sampling will be done. On the basis of inclusion criteria participants will be randomly allocate in two groups (Group A and Group B) by using computer-generated software. Group A will receive sensorimotor training for 40 mins and TACS for 20 minutes at 2mA current, for 5 days/week for 4 weeks. Group B will receive sensorimotor training for 40 minutes and sham TACS for 20 minutes per session , for 5 days/week for 4 weeks . Measurements will be taken at baseline and at 4th week. Data will be collected using Fugyl meyer assessment scale, cervical joint position error test and revised Nottingham sensory assessment scale. Data analysis will be done by SPSS software version 27. The statistical software IBM SPSS Statistics SPSS 27 will be used for calculations. After assessing the normality by Shapiro-wilk test, if the p value is greater than 0.05 the data will be distributed normally, so parametric test will be applied. If p value is less than 0.05 than non-parametric test will be applied.
8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.
This study's enrollment of 38 is below the median of 49 across 6,024 interventional studies indexed under Stroke.
Browse Stroke studies →University of Management and Technology Lahore is the lead sponsor of 39 studies on the registry; 20 are open to participants now.
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The criteria were revised on the registry on Nov 3, 2026. See what changed
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Group A will receive sensorimotor training for 40 mins and TACS for 20 minutes at 2mA current, for 5 days/week for 4 weeks. Measurements of all the outcome measures will be taken at baseline and at 4th week. Sensorimotor training tasks include texture discrimination, light touch, temperature, pinprick, pressure, Bilateral simultaneous touch, proprioception and task related to stereognosis. tACS will be administered 5 days per week for 4 weeks. After screening exclusion criteria, 25-35 cm² sponge electrodes will be positioned over the affected hemisphere's primary motor cortex (M1; C3/C4) and the contralateral supraorbital area using the 10-20 EEG system. Scalp landmarks will be measured, marked, and cleaned, and hair will be parted to ensure proper electrode contact. Saline-soaked sponge pads or conductive gel will be used, and the electrodes will be secured and connected to the stimulator. Stimulation will be delivered at 2 mA and 10 Hz for 20 minutes, with gradual ramp-up and ramp-
Other: sensorimotor training with TACS
tACS will be administered 5 days per week for 4 weeks. After screening exclusion criteria, 25-35 cm² sponge electrodes will be positioned over the affected hemisphere's primary motor cortex (M1; C3/C4) and the contralateral supraorbital area using the 10-20 EEG system. Scalp landmarks will be measured, marked, and cleaned, and hair will be parted to ensure proper electrode contact. Saline-soaked sponge pads or conductive gel will be used, and the electrodes will be secured and connected to the stimulator. Stimulation will be delivered at 2 mA and 10 Hz for 20 minutes, with gradual ramp-up and ramp-down over 15-30 seconds to minimize discomfort
Other: sensorimotor training with Sham TACS
Group A will receive sensorimotor training for 40 mins and TACS for 20 minutes at 2mA current, for 5 days/week for 4 weeks. Measurements of all the outcome measures will be taken at baseline and at 4th week. Sensorimotor training tasks include texture discrimination, light touch, temperature, pinprick, pressure, Bilateral simultaneous touch, proprioception and task related to stereognosis. tACS will be administered 5 days per week for 4 weeks. After screening exclusion criteria, 25-35 cm² sponge electrodes will be positioned over the affected hemisphere's primary motor cortex (M1; C3/C4) and the contralateral supraorbital area using the 10-20 EEG system. Scalp landmarks will be measured, marked, and cleaned, and hair will be parted to ensure proper electrode contact. Saline-soaked sponge pads or conductive gel will be used, and the electrodes will be secured and connected to the stimulator.
. Sensorimotor training tasks include texture discrimination, light touch, temperature, pinprick, pressure, Bilateral simultaneous touch, proprioception and task related to stereognosis. sensorimotor training for 40 minutes and sham TACS for 20 minutes per session , for 5 days/week for 4 weeks
joint position sense through Cervical joint position test
The Cervical Joint Position Error (JPE) Test is a measurement tool used to clinically assess an individual's cervicocephalic proprioception ability. The patient sits 90 cm from a wall-mounted target and wears a headband with a laser pointer. After recording the neutral starting position, the patient closes their eyes, moves their head in rotation (left/right), flexion, or extension, and returns to the starting position. The test is repeated three times in each direction, and the average repositioning error is calculated. A repositioning error greater than 4.5° (approximately 7 cm) indicates impaired cervical proprioception.
Time frame: at base line and after 4 weeks
somatosensory impairment through Revised Nottingham Sensory Assessment Scale
The rNSA examines somatosensory impairment using a 3-point scale (0 =absent, 1 = impaired, 2 = normal) and takes approximately 25-35 min to complete. It consists of 72 items and is grouped into three sub-scales. Tactile Sensation 54 Points \< 54 Points indicates a deficit ,Kinesthesia 12 Point \< 12 Points indicates a deficit., Stereognosis 22 Points \< 19 Points indicates impairment.
Time frame: at base line and after 4 weeks
Fugyl-Meyer Assessment for upper extremity (FMA-UE)
Fugyl-Meyer Assessment (FMA) scale is an index to assess sensorimotor impairments who have had stroke. The Fugyl-Meyer Assessment for upper extremity (FMA-UE) has been tested extensively, and is found to have excellent psychometric properties. For upper extremity assessment, Rating is from 0-50 with 0-25 points showing severe impairment and 26-50 points showing moderate impairment.
Time frame: at base line and after 4 weeks
Plan to share: Yes — The results data collected , de-identified individual participant data will be shared.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: 6 months after the publication of the manuscript.
Access criteria: The data can be requested from the corresponding author.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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University of Management and Technology Lahore