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Not yet recruitingNCT07893951Updated Oct 26, 2026

Comparison of Open vs Laparoscopic Repair of Perforated Duodenal Ulcer

An interventional study of Laparoscopic Repair of Perforated Duodenal Ulcer and Open Repair of Perforated Duodenal Ulcer in Perforated Duodenal Ulcer, sponsored by Allied Hospital Faisalabad. Not yet recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-10-26.

Sponsored by Allied Hospital Faisalabad · Not applicable, Interventional, and Treatment

Updated Oct 26, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
134
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

This randomized controlled trial aims to compare open and laparoscopic repair of perforated duodenal ulcer in terms of postoperative outcomes. A total of 134 patients will be randomly allocated into two groups: Group A will undergo laparoscopic repair and Group B will undergo open repair. The study will evaluate and compare postoperative outcomes between the two surgical approaches.

02

Conditions studied

  • Perforated Duodenal Ulcer

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03

In context

Duodenal Ulcer

79 studies on the registry are indexed under Duodenal Ulcer; 5 are open to participants now.

This study's planned enrollment of 134 is below the median of 308 across 54 interventional studies indexed under Duodenal Ulcer.

Browse Duodenal Ulcer studies →

Lead sponsor

Allied Hospital Faisalabad is the lead sponsor of 11 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Either gender
  • age 18-60 years
  • Diagnosis of perforated duodenal ulcer( as per operational definitions)

Exclusion criteria

Exclusion Criteria:

  • patients with radiological signs of air under the diaphragm but no clinical signs of peritonitis
  • patients with sealed perforation
  • Patients with shock having systolic blood pressure of less than 90mmhg
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
134 participants (estimated)

Study arms

  • Experimental
    Laparoscopic repair

    Procedure: Laparoscopic Repair of Perforated Duodenal Ulcer

  • Active comparator
    Open repair

    Procedure: Open Repair of Perforated Duodenal Ulcer

Interventions

  • ProcedureLaparoscopic Repair of Perforated Duodenal Ulcer

    Laparoscopic repair of perforated duodenal ulcer according to the standard operative technique.

  • ProcedureOpen Repair of Perforated Duodenal Ulcer

    Open surgical repair of perforated duodenal ulcer according to the standard operative technique.

06

What researchers measure

Primary outcomes

  1. Return of bowel function

    The return of bowel function will be assessed based upon the time interval from completion of surgery until appearance of bowel sounds and passage of first flatus by the patient.

    Time frame: From completion of surgery until the first passage of flatus, assessed during the postoperative hospital stay, up to 7 days after surgery

07

Study locations

1 site
08

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Oct 2026; primary completion for Jan 2027, 3 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 7, 2026
First posted
Oct 26, 2026
StartEst.
Oct 15, 2026
Primary completionEst.
Jan 30, 2027
CompletionEst.
Jan 30, 2027
Last update
Oct 26, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 26, 2026
Show all 1 update
  1. Oct 26, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07893951
Lead sponsor
Allied Hospital Faisalabad
Responsible party
Dr. Mohammad Nabi (Speciality registrar, Allied Hospital Faisalabad) — Principal investigator
First posted
Oct 26, 2026
Start date
Oct 15, 2026 (estimated)
Primary completion
Jan 30, 2027 (estimated)
Completion
Jan 30, 2027 (estimated)
Last update
Oct 26, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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