An Early Phase 1 interventional study of Ayahuasca and Ayahuasca in Healthy Adult Participants, sponsored by University of Sao Paulo. Completed at 1 site in Brazil. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by University of Sao Paulo · Early Phase 1, Interventional, and Other
Randomized, double-blind, placebo-controlled clinical trial that included 28 healthy volunteers allocated to four experimental single dose groups (n = 7 per group) (ayahuasca 0.5 mL/kg, 1.0 mL/kg, 1.5 mL/kg, or placebo)
University of Sao Paulo is the lead sponsor of 1,035 studies on the registry; 95 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
ayahuasca 0.5 mL/kg
Drug: Ayahuasca
ayahuasca 1.0 mL/kg
Drug: Ayahuasca
ayahuasca 1.5 mL/kg
Drug: Ayahuasca
Placebo
Drug: Ayahuasca · Other: Placebo
Personality assessments (primary outcome) were conducted at baseline and at a 21-day follow-up using the NEO Five-Factor Inventory-Revised (NEO-FFI-R)
Units on a Scale (NEO-FFI-R)
Time frame: baseline and 21-day follow-up
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drug tested here: Ayahuasca