An observational study in Degenerative Scoliosis, sponsored by Xuanwu Hospital, Beijing. Not yet recruiting. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2026-10-23.
Sponsored by Xuanwu Hospital, Beijing · Observational
Degenerative scoliosis can cause back pain, leg pain, difficulty walking, and impaired daily functioning. When spinal fusion is required, choosing the appropriate fusion extent remains challenging. Short-segment fusion involves fewer spinal levels, whereas long-segment fusion offers greater potential for deformity correction but requires more extensive surgery. It remains uncertain which patients are more likely to benefit from each strategy.
This multicenter prospective observational cohort study will investigate whether preoperative spinal alignment modifies the comparative clinical benefit of short-segment and long-segment fusion. Patients will receive surgery selected through routine clinical decision-making, without treatment assignment by the study. Clinical information, standing spinal radiographs, and patient-reported outcomes will be collected before surgery and during postoperative follow-up.
The primary outcome will be clinically meaningful improvement in the Scoliosis Research Society-22r subtotal score at 24 months after surgery. The study aims to identify patient subgroups with greater benefit from either fusion strategy and to develop clinically interpretable criteria that may support individualized selection of fusion extent.
Xuanwu Hospital, Beijing is the lead sponsor of 357 studies on the registry; 226 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Consecutive eligible adults older than 50 years with symptomatic de novo degenerative scoliosis who are scheduled to undergo instrumented spinal fusion at participating tertiary spine centers.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants undergoing instrumented spinal fusion involving fewer than four fused motion segments, selected through routine clinical decision-making.
Participants undergoing instrumented spinal fusion involving four or more fused motion segments, selected through routine clinical decision-making.
Achievement of the Minimum Clinically Important Difference in the Scoliosis Research Society-22r Subtotal Score
Proportion of participants achieving an increase of more than 0.98 points from baseline in the Scoliosis Research Society-22r (SRS-22r) subtotal score. The subtotal score includes the function/activity, pain, self-image, and mental health domains and excludes the satisfaction domain. Scores range from 1 to 5, with higher scores indicating better health-related quality of life.
Time frame: Baseline and 24 months after surgery.
Achievement of the Minimum Clinically Important Difference in the Oswestry Disability Index
Proportion of participants achieving a decrease of more than 18.9 points from baseline in the Oswestry Disability Index (ODI). Scores range from 0 to 100, with higher scores indicating greater disability.
Time frame: Baseline and 24 months after surgery.
Achievement of the Minimum Clinically Important Difference in Back Pain
Proportion of participants achieving a decrease of more than 1.9 points from baseline in the visual analog scale score for back pain. Scores range from 0 to 10, with higher scores indicating more severe pain.
Time frame: Baseline and 24 months after surgery.
Achievement of the Minimum Clinically Important Difference in Leg Pain
Proportion of participants achieving a decrease of more than 1.5 points from baseline in the visual analog scale score for leg pain. Scores range from 0 to 10, with higher scores indicating more severe pain.
Time frame: Baseline and 24 months after surgery.
No study locations are listed for this record.
Start is estimated for Dec 2026; primary completion for Dec 2028, 24 months later.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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