CClinicalTrials.gg
RecruitingNCT07685405BIOVESUpdated Jul 6, 2026

Identification of Circulating Biomarkers Associated With Extracellular Vesicles in Sarcomas

An observational study in Sarcoma, Ewing, sponsored by Istituto Ortopedico Rizzoli. Recruiting at 1 site in Italy. Per ClinicalTrials.gov, last updated 2026-07-06.

Sponsored by Istituto Ortopedico Rizzoli · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
16
Sex
All
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Study summary

The study involves blood samples from patients with Ewing's sarcoma to identify circulating biomarkers as a tool for the preclinical validation of innovative therapeutic approaches

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Conditions studied

  • Sarcoma, Ewing

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Sampling method
Non-probability sample

Study population

The study aims to enroll patients of any gender who are being treated at the Rizzoli Orthopedic Institute in the following departments: Orthopedic and Traumatology Clinic III (with a primary focus on oncology), General and Thoracic Surgery (for both cancer and non-cancer patients), and Osteoncology, Bone and Soft Tissue Sarcomas, and Innovative Therapies (for cancer patients only).

Eligibility criteria

Inclusion criteria for cancer patients

  • Male and female patients of any age diagnosed with Ewing sarcoma.
  • Signed, study-specific informed consent form for the BIOVES study (cancer patients)

Inclusion criteria for non-cancer patients

  • Male and female patients of legal age without a cancer diagnosis.
  • Signed, study-specific informed consent form for the BIOVES study (non-cancer patients)

Exclusion Criteria:

Patients who do not meet all inclusion criteria

-

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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
16 participants (estimated)
Patient registry
No

Groups and cohorts

  • oncological subject

    Other: 3 blood samples

  • non-oncological subjects

    Other: one blood sample

Interventions

  • Otherone blood sample

    non onco

  • Other3 blood samples

    onco

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What researchers measure

Primary outcomes

  1. characterisation of circulating biomarkers

    search for circulating biomarkers from blood samples taken at three different time points

    Time frame: at baseline (time 0); before surgery; after 6 months from surgery

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Study locations

1 of 1 sites recruiting
  • Istituto ortopedico Rizzoli Laboratorio di Ricerc Oncologica e Genomica funzioanle
    Bologna, BO 40136, Italy
    Recruiting
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Registry details

Key details

Study ID
NCT07685405
Lead sponsor
Istituto Ortopedico Rizzoli
Responsible party
Sponsor
First posted
Jul 6, 2026
Start date
Apr 15, 2026
Primary completion
Apr 2028 (estimated)
Completion
Apr 2028 (estimated)
Last update
Jul 6, 2026

Study contacts

Katia Scotlandi, MSc
Contact
katia.scotlandi@ior.it
39 051 6366760

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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