An observational study in Neurocognitive Function, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-21.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational
This randomized platform trial compared ciprofol and propofol for early neurocognitive recovery in adults undergoing painless gastrointestinal endoscopy. The primary outcome was the incidence of delayed neurocognitive recovery (dNCR) at PACU discharge, assessed via MoCA, DST, SMDT, STT, and Stroop tests (≥ 1 SD decline from baseline in ≥ 2 domains). Secondary outcomes included PACU stay duration, total drug dosage, and adverse events (hypoxemia, hypotension, bradycardia, body movement). Assessments were performed at baseline and before PACU discharge (Modified Aldrete ≥ 9).
Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 136 studies on the registry; 45 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult outpatients aged ≥ 18 years who were scheduled for elective painless gastrointestinal endoscopy and met the predefined inclusion and exclusion criteria were enrolled. Key inclusion requirements were ASA physical status I-III with stable comorbidities and provision of signed informed consent. Patients with psychiatric disorders, cognitive impairment, substance or alcohol abuse, BMI > 30 kg/m², severe organ dysfunction, or known hypersensitivity to ciprofol, propofol, or opioids were excluded.
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Exclusion Criteria:
Give Propofol Injection 2mg/kg
Drug: Ciprofol
Give Ciprofol Injection 0.4mg/kg
Incidence of delayed neurocognitive recovery (dNCR) at PACU discharge
Assessed at baseline (pre-procedure) and before PACU discharge (Modified Aldrete score ≥9). Tests: MoCA, DST, SMDT, STT, and Stroop test. dNCR defined as ≥1 SD decline from baseline in ≥2 cognitive domains.
Time frame: Baseline (pre-procedure) and before PACU discharge (Modified Aldrete score ≥9)
PACU stay duration
time from PACU admission to discharge (Modified Aldrete score ≥9).
Time frame: Intraoperatively to PACU discharge
total anesthetic dosage
cumulative ciprofol or propofol used intraoperatively (mg and mg/kg).
Time frame: Intraoperatively to PACU discharge
Incidence of hypoxemia
Defined as SpO2 \<90% during procedure or PACU stay, requiring intervention (e.g., airway support, oxygen).
Time frame: Intraoperatively to PACU discharge.
Incidence of hypotension
Defined as SBP \<80% of baseline or requiring vasoactive intervention during procedure or PACU stay.
Time frame: Intraoperatively to PACU discharge.
Incidence of bradycardia
Defined as heart rate \<50 beats/min or requiring intervention during procedure or PACU stay.
Time frame: Intraoperatively to PACU discharge.
incidence of body movement
Defined as intraoperative body movement affecting endoscopic operation, requiring additional sedative intervention.
Time frame: Intraoperatively to procedure completion.
Plan to share: Yes
No publications or documents are linked to this record.
Ran from Jul 2025 to primary completion in Oct 2026, 15 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital of Wenzhou Medical University →