An interventional study of US guided PRP injection and Rehabilitation in Traumatic Peripheral Nerve Injury, sponsored by Seham A. Elazab. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Seham A. Elazab · Not applicable, Interventional, and Treatment
This study is a prospective non randomized controlled trial evaluating the effect of ultrasound-guided platelet-rich plasma (PRP) injections on peripheral nerve regeneration.
Patients receiving PRP were compared with a control cohort managed conservatively without PRP.
90 studies on the registry are indexed under Peripheral Nerve Injuries; 24 are open to participants now.
This study's planned enrollment of 60 is above the median of 46 across 62 interventional studies indexed under Peripheral Nerve Injuries.
Browse Peripheral Nerve Injuries studies →This is the only study on the registry with Seham A. Elazab as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:
Age 18 -45 years Clinical evidence of peripheral nerve injury Electrophysiological confirmation by nerve conduction studies (NCS) Ultrasound evidence of complete or partial continuity, neuroma, or entrapment Stable neurological deficit for at least 4 weeks prior to enrollment.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Platelets
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
30 trumatic nerve injury patients
Other: US guided PRP injection · Other: Rehabilitation
rehabilitation only
Other: Rehabilitation
US guided PRP injection for injured nerve and denervated muscles
usual rehabilitation program
Change in Muscle Strength Using the Medical Research Council (MRC) Scale
Change in muscle strength of the predefined target muscle from baseline, assessed using the Medical Research Council (MRC) scale (0-5), where 0 indicates no muscle contraction and 5 indicates normal muscle strength. Higher scores indicate better muscle recovery.
Time frame: Baseline and every 3 weeks up to Week 24, including assessments at 3 and 6 months.
Change in Compound Muscle Action Potential (CMAP) Amplitude
Change in CMAP amplitude (mV) of the affected motor nerve from baseline, measured using standardized nerve conduction studies. Higher amplitudes may indicate improved motor axonal function.
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Change in Voluntary Motor Unit Recruitment on Needle EMG
Voluntary motor unit recruitment will be assessed using needle EMG during maximal voluntary contraction and graded on a four-point ordinal scale: 0 = absent, 1 = severely reduced (discrete activity), 2 = reduced (incomplete interference pattern), and 3 = full interference pattern. Assessments will be performed at baseline, 3 months, and 6 months.
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Change in Muscle Echogenicity on Ultrasound
Change in mean grayscale echogenicity of the predefined target muscle, measured from standardized ultrasound images using quantitative image analysis (0-255 grayscale units). Measurements will be obtained from a consistent anatomical location using standardized imaging settings.
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Plan to share: No
No publications or documents are linked to this record.
Started May 2026 (actual). Primary completion is estimated for Dec 2026, 7 months after the start.
Of 26 interventional studies with no phase under Peripheral Nerve Injuries, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 20 and three quarters within 57. This study's planned 7 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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