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Not yet recruitingNCT07873749Updated Oct 14, 2026

Assessment of Circulating Leptin Levels in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease

An observational study in Metabolic Dysfunction Associated Steatotic Liver Disease, sponsored by Sohag University. Not yet recruiting. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-14.

Sponsored by Sohag University · Observational

Updated Oct 14, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
96
Ages
18 Years and older
Sex
All
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Study summary

This study aims to evaluate circulating leptin levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Leptin is an adipokine involved in metabolism and inflammation. The study will assess the association between serum leptin levels and the presence or severity of MASLD compared to controls.

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Conditions studied

  • Metabolic Dysfunction Associated Steatotic Liver Disease

Keywords

  • Leptin
  • Metabolic Dysfunction-Associated Steatotic Liver Disease
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In context

Lead sponsor

Sohag University is the lead sponsor of 1,218 studies on the registry; 627 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients attending the Gastroenterology and Hepatology outpatient clinics or inpatient departments at Sohag University Hospitals, along with healthy volunteers matched for age and sex.

Eligibility criteria

Inclusion Criteria: Patient older than 18 years diagnosed with MASLD according to Delphi consensus criteria In addition to a control group of healthy individuals, matched to them in age, sex and number.

-

Exclusion Criteria: 1-Significant alcohol consumption (>20 g/day for females, >30 g/day for males).

2-Other causes of chronic liver disease:

  • Viral hepatitis (HBV, HCV)
  • Autoimmune hepatitis.
  • Wilson's disease.
  • Hemochromatosis.
  • Drug-induced liver injury. 3-Active infection or acute inflammatory conditions. 4- Malignancy. 5-Pregnancy.
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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
96 participants (estimated)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • MASLD Patient

    Patients diagnosed with Metabolic Dysfunction-Associated Steatotic Liver Disease

    Other: Serum Leptin Measurement

  • Healthy controls

    Other: Serum Leptin Measurement

Interventions

  • OtherSerum Leptin Measurement

    evaluate circulating leptin levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

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What researchers measure

Primary outcomes

  1. Serum Leptin Levels

    Serum concentration of leptin measured in ng/mL using enzyme-linked immunosorbent assay (ELISA) in patients with MASLD compared to controls.

    Time frame: At baseline (upon study enrollment for each participant)

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 14, 2026
Show all 1 update
  1. Oct 14, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07873749
Lead sponsor
Sohag University
Responsible party
Mayada Arfat Mohamed (M.B.B.Ch., M.Sc., Sohag University) — Principal investigator
First posted
Oct 14, 2026
Start date
Oct 15, 2026 (estimated)
Primary completion
Feb 1, 2027 (estimated)
Completion
Jun 15, 2027 (estimated)
Last update
Oct 14, 2026

Study contacts

Mayada Arafat Mohamed, M.B.B.Ch., M.Sc.
Contact
maiada.arfat@med.sohag.edu.eg
01065597423

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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