An interventional study of Finger Prick- Blood Glucose and Whole Blood Draw in Pre Diabetes, sponsored by Cornell University. Active, not recruiting at 1 site in United States. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-14.
Sponsored by Cornell University · Not applicable, Interventional, and Prevention
There is emerging evidence that the order in which food is consumed in a meal, known as the "nutrient sequence", can have protective health effects against obesity and metabolic disease. These studies show that consuming food sources rich in protein before consuming carbohydrates will significantly lower blood glucose levels equivalent to many glucose-lowering medications. This nutrition intervention can have tremendous therapeutic potential in individuals who are pre-diabetic and prevent the onset of obesity. Surprisingly, however, there are no studies to date that have comprehensively tested this efficacy in young health adults. This research proposal will define the response of nutrient sequencing in young healthy individuals to determine if this intervention can improve metabolic profiles such as normalizing blood glucose levels to healthy parameters in order to prevent obesity and type 2 diabetes. We will 1) test if the metabolic benefits of Nutrient Sequencing can extend across different populations in NY state, and 2) define the mechanism of the metabolic response to nutrient sequencing interventions by capturing participant circulating blood proteome and metabolome.
792 studies on the registry are indexed under Glucose Intolerance; 126 are open to participants now.
This study's planned enrollment of 40 is below the median of 60 across 656 interventional studies indexed under Glucose Intolerance.
Browse Glucose Intolerance studies →Cornell University is the lead sponsor of 103 studies on the registry; 18 are open to participants now.
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Exclusion Criteria:
Control Diet: turkey sausage, white bread toast with strawberry jelly, and orange juice consumed in a mixed format within 30min.
Procedure: Finger Prick- Blood Glucose · Procedure: Whole Blood Draw · Behavioral: Diet History Questionnaire · Behavioral: Physical Activity Assessment
Nutrient Sequencing Diet: turkey sausage, white bread toast with strawberry jelly, water. Participants will consume the turkey sausage first and then 10 minutes after they will consume the toast with jelly and orange juice in 20 minutes (Total time = 30 minutes)
Procedure: Finger Prick- Blood Glucose · Procedure: Whole Blood Draw · Behavioral: Diet History Questionnaire · Behavioral: Physical Activity Assessment
Measurement of Blood glucose via finger prick
Collection of whole blood for plasma and serum measurements
Assessment of dietary frequency patterns via DHQ III
Assessment of habitual physical activity via IPAQ survey
Blood Glucose
Time frame: Collected via finger prick (5 collection points- Timepoints 0, 30, 60, 90, and 120mins) for both Visit 1 at baseline and Visit 2 which occurs 1 week later after the washout period.
Body Fat Percentage
Time frame: Collected during Visit 1at baseline via bioelectrical impedance analysis (BIA).
Blood Insulin Levels
Time frame: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood insulin levels will be measured two weeks after Visit 2.
Leptin Blood Measurement
Time frame: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood leptin levels will be measured two weeks after Visit 2.
Healthy Eating Index
Time frame: Collected during Visit 1 at baseline using the DHQIII diet frequency questionnaire.
Plan to share: Yes
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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