An interventional study of EXERCISE TRAINING WITH OR WITHOUT MEDICATION in Parkinson's Disease (PD), sponsored by Palacky University. Recruiting at 1 site in Czechia. Open to participants aged 50 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Palacky University · Not applicable, Interventional, and Treatment
This interventional study aims to assess self-sufficiency in patients with Parkinson's disease in the spa setting using the new Czech Functional Efficiency of Self-sufficiency Test (FEST) and to validate the test in this population. It also aims to evaluate changes in cognition, stability, fear of falling, and gait after specialized spa care and to analyze correlations between self-sufficiency and these outcomes.
The research includes the validation of a Czech self-sufficiency test designed primarily for patients after a stroke. The aim is to validate this tool in patients with Parkinson's disease (PD). The research will also include the possible modification of certain categories that are characteristic of PD patients, as well as the scoring of the test. The study will include patients undergoing comprehensive spa treatment at a Czech spa facility. The inclusion criteria are: 1/idiopathic PD, 2/disease severity 1-3 according to the Hoehn and Yahr scale, 3/age 50-80 years, 4/ability to walk independently, 5/minimum score ≤76 in Adenbrooke's Cognitive Examination. Exclusion criteria: 1/moderate to severe dementia, 2/other comorbidities affecting the gait (e.g. post-stroke condition, vertigo,...), 3/psychiatric disorders, 4/severe sensory impairments that would limit the implementation of the rehabilitation plan. The research will also evaluate changes in selected parameters, namely: cognition, stability, gait, and fear of falling. The research will also examine whether there is a correlation between self-sufficiency and these factors. Patients will be tested upon admission to care, then undergo a 3-week rehabilitation program, followed by a follow-up measurement.
Standardized tests were selected for research purposes:
Self-sufficiency: Barthel Index, FEST Fear of falling: Short Falls Efficacy Scale - International Stability: Mini-Balance Evaluation Systems Test, measurement on a stabilometric platform Cognition: Adenbrooke's Cognitive Examination (ACE-III) Gait: 6-minute walk test Descriptive statistics and correlation will be used for data processing.
4,583 studies on the registry are indexed under Parkinson Disease; 1,097 are open to participants now.
This study's planned enrollment of 50 is above the median of 40 across 3,365 interventional studies indexed under Parkinson Disease.
Browse Parkinson Disease studies →Palacky University is the lead sponsor of 32 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with Parkinson's disease undergo comprehensive spa treatment, which includes: individual therapeutic physical education, group exercises - exercises on balance balls, exercises in the pool, balance training on Nintendo Wii, Nordic walking, Qi Gong. In addition to active therapy, the treatment also utilizes the effects of natural resources on the body - iodine-bromine water in the form of compresses and baths, massages - aromatherapy, classic massages.
Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Patients undergo therapies led by clinical experts in the field of physical therapy. Individual therapies include soft tissue therapies, exercises aimed at increasing/maintaining range of motion, increasing muscle strength, balance, cognition, and self-sufficiency. The comprehensive rehabilitation stay will also include the use of natural healing resources - iodine-bromine brine, combined with active therapy.
Also known as: Active exercising, rehabilitation care
Change in Self-Sufficiency Test Score
Change in the total score of the Functional Efficiency of Self-Sufficiency Test from baseline to completion of the rehabilitation program. The total score ranges from 0 to 100 points, with higher scores indicating greater functional independence. Unit of measure: points Measurement tool: Functional Efficiency of Self-Sufficiency Test
Time frame: 3 weeks
Change in Addenbrooke's Cognitive Examination III (ACE-III) Score
Change in the total Addenbrooke's Cognitive Examination III (ACE-III) score from baseline to completion of the rehabilitation program. The ACE-III total score ranges from 0 to 100 points, with higher scores indicating better cognitive performance. Unit of measure: points Measurement tool: Addenbrooke's Cognitive Examination III (ACE-III)
Time frame: 3 weeks
Change in Short Falls Efficacy Scale-International (Short FES-I) Score
Change in the total Short Falls Efficacy Scale-International (Short FES-I) score from baseline to completion of the rehabilitation program. The total score ranges from 7 to 28 points, with higher scores indicating greater concern about falling. Unit of measure: points Measurement tool: Short Falls Efficacy Scale-International (Short FES-I)
Time frame: 3 weeks
Change in Mini-BESTest Score
Change in the total Mini-Balance Evaluation Systems Test (Mini-BESTest) score from baseline to completion of the rehabilitation program. The total score ranges from 0 to 28 points, with higher scores indicating better dynamic balance. Unit of measure: points Measurement tool: Mini-Balance Evaluation Systems Test (Mini-BESTest)
Time frame: 3 weeks
Change in Weight-Bearing Asymmetry Measured Using a Force Platform
Change in weight-bearing asymmetry during 30-second quiet standing from baseline to completion of the rehabilitation program, measured using a force platform. Weight-bearing asymmetry is expressed as the absolute difference between the percentage load on the left and right sides. Lower values indicate more symmetrical weight distribution. Unit of measure: percentage points Measurement tool: Force platform
Time frame: 3 weeks
Change in Six-Minute Walk Test Distance
Change in the distance walked during the Six-Minute Walk Test (6MWT) from baseline to completion of the rehabilitation program. A greater walking distance indicates better functional exercise capacity. Unit of measure: meters (m) Measurement tool: Six-Minute Walk Test (6MWT)
Time frame: 3 weeks
Plan to share: No
No publications or documents are linked to this record.
Started Nov 2024 (actual). Primary completion is estimated for Mar 2027, 28 months after the start.
Of 1,296 non-industry interventional studies with no phase under Parkinson Disease, half reached primary completion within 24 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 45. This study's planned 28 months is above that.
Counting every sponsor, half of 1,369 studies reached it within 24 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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