An observational study in Athletic Injury and Fatigue Recovery, sponsored by Palacky University. Recruiting at 1 site in Czechia. Open to male participants aged 15 Years to 19 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Palacky University · Observational
This study protocol describes a prospective longitudinal observational study designed to evaluate the accuracy of machine learning models in predicting the short-term (24-72 h) risk of reduced participation (training modification or absence due to health complaints, injury, or illness) among elite youth football players (categories U16 to U19).
Full participation in training and matches is a key determinant of athletic development and squad availability in elite youth football. Conventional injury surveillance typically reduces athlete availability to a binary time-loss state and overlooks the continuum on which athletes remain active despite emerging fatigue, minor musculoskeletal complaints, or functional limitations.
In this study, continuous multimodal monitoring integrates external training and match locomotion (Catapult Vector 10 Hz GNSS / 100 Hz IMU), nocturnal autonomic nervous regulation (WHOOP 5.0 wrist-worn photoplethysmography evaluating resting heart rate, heart rate variability RMSSD, and sleep architecture), daily subjective wellness (AMS Hooper Index: sleep quality, stress, fatigue, mood, and muscle soreness), weekly neuromuscular screening (VALD ForceDecks countermovement jumps and NordBord hamstring strength), and anthropometrics with biological maturation offset.
Participation status is adjudicated daily by designated coaching and medical staff. The primary objective is to develop, compare, and internally validate short-term prediction models for the onset transition from full participation to reduced participation, formulated as a single one-step discrete-time hazard read coherently across 24-, 48-, and 72-hour operational horizons. The study aims to evaluate explainable machine learning models (Survival XGBoost, GAMM with SHAP/LIME interpretation) to support training load management and injury risk mitigation within elite academies.
STUDY DESIGN AND COHORT:
This is a prospective, longitudinal, single-site observational cohort study conducted across one complete 10-month competitive season (2026/2027) within the U16 and U19 squads of an elite youth football academy (SK Sigma Olomouc, Czechia). The cohort comprises approximately 30 elite male youth football players. The unit of analysis is the at-risk player-day in full participation (longitudinal person-period array), yielding an estimated 6,000 to 8,000 observed player-days.
PRIMARY OUTCOME (TARGET VARIABLE):
The primary outcome is the staff-adjudicated transition event from full participation into any lower category of the daily participation gradient (modified training with >20% volume reduction, reduced training intensity, or complete absence due to medical/health reasons). Conditional on full participation on day t, the primary modeled quantity is the one-step discrete-time onset hazard. Operational cumulative onset probabilities are read coherently across 24-, 48-, and 72-hour horizons. To ensure outcome adjudication reliability, an inter-rater agreement analysis (Cohen's kappa) is performed between independent staff members.
MULTIMODAL PREDICTOR DOMAINS:
Candidate predictors span eight pre-specified canonical domains (\~31 candidate variables; \~33-36 parameters after categorical expansion):
RESAMPLING AND LEAKAGE DISCIPLINE:
Model evaluation operates via a calendar-aligned rolling-origin cross-validation scheme with an expanding training window and temporally subsequent held-out test blocks. To prevent data leakage across the train/test boundary, an embedded temporal embargo of >=72 hours is implemented. All data-dependent preprocessing steps (imputation via MICE/PMM, scaling, dimensionality reduction) are fitted strictly within the training partition of each resample and applied to held-out test data.
STATISTICAL MODELLING AND EVALUATION:
Pre-specified candidate models include baseline logistic regressions, Generalised Additive Mixed Models (GAMM) with player-level random intercepts, and tree-based learners (Survival XGBoost with functional monotonicity constraints). Model evaluation follows a calibration-first hierarchy (Brier score, calibration slopes/curves), followed by discrimination under class imbalance (Precision-Recall AUC, Matthews Correlation Coefficient). Model behavior and domain contributions are interpreted using explainable artificial intelligence (XAI) frameworks (SHAP and LIME).
273 studies on the registry are indexed under Athletic Injuries; 43 are open to participants now.
This study's planned enrollment of 30 is below the median of 100 across 103 observational studies indexed under Athletic Injuries.
Browse Athletic Injuries studies →Palacky University is the lead sponsor of 32 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Elite male youth football players (categories U16 and U19) registered in a licensed national youth football academy (SK Sigma Olomouc, Czechia) competing in top-tier national youth leagues.
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Exclusion Criteria:
Approximately 30 registered male youth football players from U16 and U19 academy squads (SK Sigma Olomouc) undergoing regular training and competitive match microcycles with continuous multimodal monitoring across one full season.
Short-Term Incidence of Change in Participation Status (24, 48, and 72-Hour Discrete-Time Hazard)
Daily morning consensus assessment (at 8:30 AM) of player participation recorded in the club Athlete Management System (AMS) on a 3-point ordinal scale: Full participation (0), Modified training with \>20% volume restriction or sprint restriction due to medical/health complaints (1), and Complete absence due to injury or illness (2). Transitions from full participation to modified training or absence (Levels 1 and 2) are modeled as a binary event of participation status change under a discrete-time survival framework with a 3-day clean washout period (W = 3) for re-entry into the risk set.
Time frame: Daily assessments across one complete 10-month competitive football season (predicting transitions within 24, 48, and 72 hours).
Plan to share: No
No publications or documents are linked to this record.
Started Jul 2026 (actual). Primary completion is estimated for Jun 2027, 11 months after the start.
Of 40 non-industry observational studies under Athletic Injuries, half reached primary completion within 7 months of starting (the median), counting those still running; a quarter within 2 and three quarters within 11. This study's planned 11 months is above that.
Counting every sponsor, half of 40 studies reached it within 7 months; a quarter within 2 and three quarters within 11.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Palacky University