An observational study in Knee Osteoarthritis, sponsored by Mardin Artuklu University. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-10-09.
Sponsored by Mardin Artuklu University · Observational
People with knee osteoarthritis may have similar levels of pain but very different abilities to walk, rise from a chair, and perform daily activities. This study aims to examine the factors associated with these differences in functional capacity among patients with similar knee pain severity.
Adults with radiographic knee osteoarthritis and an average knee pain level of 4-6 on a 0-10 scale will be included. During a single study visit, participants will complete questionnaires about physical function, central sensitization-related symptoms, and physical activity. They will also perform a 10-meter walk test, a 30-second chair stand test, and the Timed Up and Go test.
Self-reported physical function will be assessed using the function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index. Participants with better and poorer function will be compared, and the clinical factors independently associated with functional capacity will be examined. No treatment or intervention will be assigned as part of this study.
Pain severity does not fully explain functional limitation in knee osteoarthritis. Patients with similar levels of knee pain may differ substantially in their ability to perform daily activities and physical tasks. This study will examine functional capacity within a group of patients whose pain severity is restricted to a similar moderate range.
In this study, "functional reserve" refers to the relative preservation of function among patients with comparable pain intensity. It is a study-specific operational concept rather than a separate validated measurement scale. Functional capacity will be evaluated using the function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index. Higher scores indicate greater functional limitation.
The primary analysis will use the function score as a continuous variable in the full study sample. Multivariable linear regression will be used to examine whether demographic and clinical characteristics, radiographic disease severity, central sensitization-related symptom burden, and physical activity are independently associated with functional capacity.
An additional group-based analysis will compare participants in the lowest 25% and highest 25% of the function score distribution. The lowest quartile, representing less functional limitation, will be defined as the higher functional reserve group. The highest quartile, representing greater functional limitation, will be defined as the lower functional reserve group. These groups will be compared in terms of objective physical performance and relevant clinical characteristics. This approach will be used to explore why patients with similar pain severity may have markedly different levels of function.
3,391 studies on the registry are indexed under Osteoarthritis, Knee; 628 are open to participants now.
This study's planned enrollment of 120 is above the median of 100 across 484 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Mardin Artuklu University is the lead sponsor of 32 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population will consist of adults attending the Physical Medicine and Rehabilitation outpatient clinic of Mardin Training and Research Hospital with clinical and radiographic knee osteoarthritis. Only patients with Kellgren-Lawrence grade 2 or 3 disease and similar moderate knee pain severity will be included. No healthy control group will be enrolled.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adults aged 40-75 years with clinical and radiographic knee osteoarthritis of Kellgren-Lawrence grade 2 or 3 and an average knee pain intensity of 4-6 on a 0-10 visual analog scale during the previous week.d.
Self-Reported Physical Function Assessed by the WOMAC Function Subscale
Self-reported functional limitation will be assessed using the 17-item function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Each item is scored from 0 to 4, producing a total score ranging from 0 to 68. Higher scores indicate greater functional limitation and worse physical function.
Time frame: Baseline
Walking Speed Assessed by the 10-Meter Walk Test
Participants will walk a 10-meter distance at their usual walking pace. Completion time will be recorded in seconds, and walking speed will be calculated in meters per second. Higher walking speed indicates better physical performance.
Time frame: Baseline
Chair Stand Performance Assessed by the 30-Second Chair Stand Test
The number of complete sit-to-stand repetitions performed within 30 seconds will be recorded. The score has a minimum of 0 repetitions and no predefined maximum. A higher number of repetitions indicates better lower-extremity functional performance.
Time frame: Baseline
Functional Mobility Assessed by the Timed Up and Go Test
The time required to stand up from a chair, walk 3 meters, turn, return to the chair, and sit down will be recorded in seconds. The measure has a minimum of 0 seconds and no predefined maximum. A longer completion time indicates poorer functional mobility.
Time frame: Baseline
Central Sensitization-Related Symptom Burden Assessed by the Central Sensitization Inventory
Central sensitization-related symptom burden will be assessed using Part A of the 25-item Central Sensitization Inventory. Each item is scored from 0 to 4, producing a total score ranging from 0 to 100. Higher scores indicate a greater burden of central sensitization-related symptoms.
Time frame: Baseline
Weekly Physical Activity Duration
The total duration of walking and/or moderate-intensity physical activity performed during the previous week will be recorded in minutes per week. Higher values indicate a longer duration of physical activity. Participants will also be categorized as performing less than 150 minutes or at least 150 minutes of physical activity per week.
Time frame: Baseline
Plan to share: No
Started Aug 2026 (actual). Primary completion is estimated for May 2027, 9 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Mardin Artuklu University