An interventional study of Scaling and Root Planing (SRP) in Periodontitis and Obesity (Body Mass Index >30 kg/m2), sponsored by Emine Çifcibaşı. Completed. Open to participants aged 25 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-09.
Sponsored by Emine Çifcibaşı · Not applicable, Interventional, and Treatment
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally healthy, and normal-weight periodontally healthy. Clinical periodontal parameters and salivary levels of IL-6, IL-10, TNF-α, and adiponectin were assessed at baseline in all participants. Individuals with periodontitis received non-surgical periodontal therapy, and clinical and biochemical evaluations were repeated after 3 months.
This study was designed to investigate the interaction between obesity and periodontitis in terms of clinical periodontal status and systemic inflammatory burden, as well as to evaluate whether obesity modifies the response to non-surgical periodontal therapy.
Participants were categorized into four groups according to body mass index (BMI) and periodontal status: obese individuals with periodontitis, normal-weight individuals with periodontitis, obese periodontally healthy controls, and normal-weight periodontally healthy controls. Clinical periodontal parameters, including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP), were recorded at baseline. Salivary inflammatory biomarkers, including C-reactive protein (CRP) and interleukin-6 (IL-6), were analyzed to assess systemic and local inflammatory profiles.
Non-surgical periodontal therapy was performed in participants diagnosed with periodontitis. Clinical and salivary parameters were re-evaluated following treatment to determine therapeutic response.
The primary objectives were: (1) to assess whether obesity is associated with differences in baseline periodontal and inflammatory parameters, and (2) to determine whether obesity influences the clinical and inflammatory outcomes of non-surgical periodontal therapy.
1,664 studies on the registry are indexed under Periodontitis; 328 are open to participants now.
This study's enrollment of 80 is above the median of 45 across 1,206 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →This is the only study on the registry with Emine Çifcibaşı as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: Adults aged 25-50 years
For periodontitis groups: diagnosis of periodontitis according to clinical criteria (presence of periodontal pockets and clinical attachment loss)
For healthy control groups: absence of clinical signs of periodontitis
Body mass index (BMI) ≥30 kg/m² for obese groups
Body mass index (BMI) 18.5-24.9 kg/m² for normal-weight groups
Systemically healthy individuals
No periodontal treatment within the previous 6 months
Willingness to participate and provide informed consent -
Exclusion Criteria: Presence of systemic diseases that could affect periodontal status or inflammatory response (e.g., diabetes mellitus, autoimmune disorders)
Use of antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the past 3 months
Periodontal treatment within the previous 6 months
Current pregnancy or lactation
History of smoking or current tobacco use
Presence of acute oral infections other than periodontitis
Any condition that could interfere with study participation or outcome assessment
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Participants with a body mass index (BMI) ≥30 kg/m² diagnosed with periodontitis. Clinical periodontal parameters and salivary inflammatory biomarkers were recorded at baseline. Non-surgical periodontal therapy (scaling and root planing) was performed, and clinical and biochemical outcomes were re-evaluated following treatment.
Procedure: Scaling and Root Planing (SRP)
Participants with a BMI between 18.5-24.9 kg/m² diagnosed with periodontitis. Baseline clinical periodontal measurements and salivary inflammatory biomarkers were assessed. Non-surgical periodontal therapy was provided, and post-treatment clinical and inflammatory responses were analyzed.
Procedure: Scaling and Root Planing (SRP)
Participants with a BMI ≥30 kg/m² and no clinical signs of periodontitis. Clinical periodontal parameters and salivary inflammatory biomarkers were assessed at baseline. No periodontal treatment was administered.
articipants with a BMI between 18.5-24.9 kg/m² and clinically healthy periodontal tissues. Baseline clinical and salivary inflammatory parameters were recorded. No intervention was performed.
Non-surgical periodontal therapy consisting of scaling and root planing was performed using hand and ultrasonic instruments under local anesthesia when necessary. Supra- and subgingival plaque and calculus were removed. Oral hygiene instructions were provided to all participants. Treatment was completed within the standard clinical protocol.
Change in Probing Pocket Depth (PPD) After Non-Surgical Periodontal Therapy
Probing pocket depth (PPD) was measured in millimeters using a Williams periodontal probe at baseline and at the 3-month follow-up. The change from baseline to 3 months was calculated to assess the clinical response to non-surgical periodontal therapy.
Time frame: Baseline to 3 months
Change in Clinical Attachment Level (CAL) After Non-Surgical Periodontal Therapy
Clinical attachment level (CAL) was measured in millimeters using a Williams periodontal probe at baseline and at the 3-month follow-up. The change from baseline to 3 months was calculated to assess the clinical response to non-surgical periodontal therapy.
Time frame: Baseline to 3 months
No study locations are listed for this record.
Documents are hosted by the registry — open the source record to download them.
Plan to share: No — ndividual participant data will not be shared due to ethical and privacy considerations, as the original informed consent did not include provisions for public data sharing.
Ran from Jan 2015 to primary completion in Apr 2015, 3 months.
Of 605 non-industry interventional studies with no phase under Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 28. This study's 3 months is below that.
Counting every sponsor, half of 624 studies reached it within 15 months; a quarter within 7 and three quarters within 28.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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