An observational study in Nutcracker Syndrome, Renal, sponsored by Kanuni Sultan Suleyman Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 0 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-10-09.
Sponsored by Kanuni Sultan Suleyman Training and Research Hospital · Observational
Nutcracker syndrome occurs when the vein carrying blood from the left kidney is compressed between nearby blood vessels. This can cause protein or blood to appear in the urine.
This observational study examined changes in body composition, urine protein levels, and kidney Doppler ultrasound measurements in children with nutcracker syndrome who received nutritional counseling during conservative care. Measurements taken at the start of the study were compared with those taken six months later. The study also examined relationships between body composition, urine protein levels, and ultrasound measurements. There was no comparison group.
243 studies on the registry are indexed under Proteinuria; 45 are open to participants now.
This study's enrollment of 96 is below the median of 178 across 55 observational studies indexed under Proteinuria.
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Children with a pre-existing diagnosis of nutcracker syndrome attending the pediatric nephrology clinic at Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Türkiye. Diagnosis had been established during routine clinical care on the basis of orthostatic proteinuria and renal Doppler findings.
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Exclusion Criteria:
- Severe intellectual disability.
Children with a pre-existing diagnosis of nutcracker syndrome who received nutritional counseling during conservative care. Body composition, urinary protein excretion, and renal Doppler parameters were assessed at baseline and six months.
Behavioral: Nutritional Counseling
Children and their parents received verbal and written advice on healthy nutrition, including a diet plan providing adequate calories for the child's age and sex. Dietitian-prepared brochures recommended that carbohydrates provide 45-65% of total calories, protein 10-30%, and fat 25-35%. Foods rich in omega-3 fatty acids, calcium, and iron were recommended. Participants were reassessed six months after the initial counseling.
Change in Urinary Protein Excretion
Urinary protein excretion measured in a timed urine collection and expressed in mg/m²/hour. The change from baseline to six months was assessed.
Time frame: Baseline and 6 months
Change in Body Composition Parameters
Body composition parameters (body mass index z-score, fat mass, and fat-free mass) measured by bioelectrical impedance analysis at baseline and six months after nutritional counseling.
Time frame: Baseline and 6 months
Change in Renal Doppler Parameters
Left renal vein peak velocity ratio and anteroposterior diameter ratio measured by Doppler ultrasonography at baseline and six months after nutritional counseling. Time Frame: Baseline and 6 months
Time frame: Baseline and 6 months
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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