An observational study in Myasthenia Gravis and Thymoma, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-01.
Sponsored by Assiut University · Observational
Myasthenia gravis is an autoimmune disorder affecting neuromuscular transmission, characterized by fluctuating muscle weakness and fatigue. Surgical removal of the thymus gland (thymectomy) is an established treatment to help achieve disease control in eligible patients. However, surgery does not guarantee permanent remission, and some individuals experience disease recurrence or clinical worsening.
The main objective of this observational study is to determine the incidence and clinical predictors of early relapse occurring within the first six months following thymectomy. The study evaluates adult patients with confirmed autoimmune myasthenia gravis who underwent thymectomy at Assiut University Hospitals. Patient characteristics, antibody profiles, pre-surgical disease severity, and postoperative follow-up assessments at 1, 3, and 6 months will be analyzed to identify factors associated with early clinical relapse.
324 studies on the registry are indexed under Myasthenia Gravis; 146 are open to participants now.
This study's planned enrollment of 30 is below the median of 140 across 104 observational studies indexed under Myasthenia Gravis.
Browse Myasthenia Gravis studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Adult patients diagnosed with definite autoimmune myasthenia gravis who underwent thymectomy at Assiut University Hospitals and have documented clinical follow-up for at least six months post-surgery.
Exclusion Criteria:
Adult patients aged 18 years or older with definite autoimmune myasthenia gravis who underwent thymectomy at Assiut University Hospitals. This cohort is evaluated for the incidence, clinical phenotype, and predictors of early clinical relapse occurring within six months post-thymectomy.
Number of Participants With Clinically Significant Myasthenia Gravis Relapse
Clinically significant relapse is defined as an objective worsening of myasthenia gravis muscle weakness that requires treatment escalation (including increased corticosteroid dosing, addition of non-steroidal immunosuppressive agents, or initiation of rescue therapy with plasma exchange or intravenous immunoglobulin).
Time frame: 6 months post-thymectomy
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Assiut University