An observational study in Polycystic Ovarian Syndrome (PCOS), sponsored by Cumhuriyet University. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 43 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Cumhuriyet University · Observational
This prospective observational case-control study evaluated serum BRCC36 and telomerase (TE) levels in women with polycystic ovary syndrome (PCOS) and healthy controls. Women aged 18-43 years were included. The study comprised 30 women diagnosed with PCOS according to ESHRE/ASRM criteria and 30 healthy women with regular menstrual cycles. A single 5-mL venous blood sample was collected from each participant. Serum was separated by centrifugation and stored at -80°C until analysis. Serum BRCC36 and telomerase levels were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits. The study evaluated differences in these biomarkers between women with PCOS and healthy controls and their relationships with clinical and biochemical characteristics.
This prospective observational case-control study included women aged 18-43 years with polycystic ovary syndrome (PCOS) and healthy controls. PCOS was diagnosed according to ESHRE/ASRM criteria based on the presence of at least two of the following features: oligo- and/or anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovarian morphology on ultrasonography.
Participants underwent clinical and anthropometric evaluation, including body mass index and modified Ferriman-Gallwey scoring. Available biochemical and hormonal parameters obtained during routine clinical evaluation were also recorded.
For the study-specific biomarker analyses, a single 5-mL venous blood sample was collected from each participant into a serum separator tube. Samples were centrifuged at 3000 rpm for 10 minutes, and the separated sera were stored at -80°C until analysis. Serum BRCC36, a deubiquitinating enzyme-related biomarker, and telomerase (TE) levels were measured using commercially available human ELISA kits.
The primary objective was to compare serum BRCC36 and telomerase levels between women with PCOS and healthy controls. Associations between these biomarkers and clinical and biochemical characteristics were also evaluated.
944 studies on the registry are indexed under Polycystic Ovary Syndrome; 175 are open to participants now.
This study's enrollment of 60 is below the median of 118 across 223 observational studies indexed under Polycystic Ovary Syndrome.
Browse Polycystic Ovary Syndrome studies →Cumhuriyet University is the lead sponsor of 128 studies on the registry; 25 are open to participants now.
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Women aged 18-43 years attending Sivas Cumhuriyet University Faculty of Medicine Hospital were included. The study population consisted of 30 women diagnosed with PCOS according to ESHRE/ASRM criteria and 30 healthy women with regular menstrual cycles who served as controls. All participants were non-obese (BMI \<30 kg/m²) and provided written informed consent.
Exclusion Criteria:
Women aged 18-43 years diagnosed with polycystic ovary syndrome according to ESHRE/ASRM criteria (n=30).
Healthy women aged 18-43 years with regular menstrual cycles and without clinical or ultrasonographic features of PCOS (n=30).
Serum BRCC36 Level
Serum BRCC36 levels measured using a commercially available human ELISA kit and compared between the PCOS and healthy control groups.
Time frame: At study enrollment (single blood collection)
Serum Telomerase Level
Serum telomerase (TE) levels measured using a commercially available human ELISA kit and compared between the PCOS and healthy control groups.
Time frame: At study enrollment (single blood collection)
Plan to share: No — maybe after de article submission i will plan to share.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Cumhuriyet University