An interventional study of Acacia arabica Mouth Rinse and acacia arabica paste in Gingival and Periodontal Disease, sponsored by Umm Al-Qura University. Completed at 1 site in Saudi Arabia. Open to participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-09-24.
Sponsored by Umm Al-Qura University · Not applicable, Interventional, and Treatment
This randomized clinical pilot study evaluated the short-term effects of Acacia arabica mouth rinse and paste as adjuncts to conventional oral hygiene in adults with plaque-induced gingivitis. Thirty systemically healthy participants aged 18-42 years were randomly allocated into three groups: a control group receiving conventional oral hygiene measures, an Acacia arabica mouth rinse group, and an Acacia arabica paste group. All participants received professional plaque removal and standardized oral hygiene instructions at baseline. Participants in the intervention groups additionally used either the Acacia arabica mouth rinse or paste twice daily for four weeks. Clinical assessments were performed at baseline, 2 weeks, and 4 weeks. The study evaluated changes in plaque index, gingival index, bleeding on probing, and salivary pH. The study aimed to determine whether Acacia arabica formulations could provide additional short-term benefits in plaque and gingival inflammation control compared with conventional oral hygiene measures alone.
867 studies on the registry are indexed under Periodontal Diseases; 189 are open to participants now.
This study's enrollment of 30 is below the median of 45 across 557 interventional studies indexed under Periodontal Diseases.
Browse Periodontal Diseases studies →Umm Al-Qura University is the lead sponsor of 47 studies on the registry; 5 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
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An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants received professional plaque removal at baseline and standardized oral hygiene instructions, including the modified Bass brushing technique. Participants were instructed to brush twice daily using a regular fluoridated toothpaste and received no Acacia arabica intervention during the 4-week study period.
Participants received professional plaque removal and standardized oral hygiene instructions at baseline. In addition, participants used 10 mL of Acacia arabica mouth rinse, prepared at a concentration of 1 g of extract per 10 mL of distilled water, twice daily after toothbrushing for 4 weeks. Participants were instructed to swish the solution for 1 minute, retain it intraorally for an additional 2 minutes, and then expectorate.
Other: Acacia arabica Mouth Rinse
Participants received professional plaque removal and standardized oral hygiene instructions at baseline. In addition, participants applied a pea-sized amount of Acacia arabica paste (Gumtone® gel) to the gingiva twice daily after toothbrushing for 4 weeks. The paste was gently massaged into the gingiva for approximately 2 minutes and subsequently removed using gauze.
Other: acacia arabica paste
the rinse as 1 g extract/10 mL distilled water
a pea-sized amount of Acacia arabica paste (Gumtone® gel)
Change in Gingival Index (GI)
Gingival inflammation was assessed using the Gingival Index at baseline, 2 weeks, and 4 weeks. The index was used to evaluate changes in the severity of gingival inflammation during the intervention period. Lower scores indicate less gingival inflammation and better gingival health.
Time frame: Baseline, 2 weeks, and 4 weeks
Change in Plaque Index (PI)
Plaque accumulation was assessed using the Plaque Index at baseline, 2 weeks, and 4 weeks. The index was used to quantify changes in dental plaque accumulation during the intervention period. Lower scores indicate less plaque accumulation and better plaque control.
Time frame: Baseline, 2 weeks, and 4 weeks
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No — Individual participant data are not planned to be publicly shared due to participant confidentiality and institutional ethical considerations. De-identified data supporting the findings may be made available from the corresponding investigator upon reasonable request and subject to institutional and ethical approval.
Ran from Jan 2025 to primary completion in Aug 2025, 7 months.
Of 312 non-industry interventional studies with no phase under Periodontal Diseases, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 27. This study's 7 months is below that.
Counting every sponsor, half of 331 studies reached it within 13 months; a quarter within 8 and three quarters within 26.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Umm Al-Qura University