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CompletedNCT07833449MUQ-HIVUpdated Sep 22, 2026

The Effect of Murottal Quran on Fatigue Severity Scale and Shatri-Sinulingga Psychosomatic Test Scores in Patients With Human Immunodeficiency Virus Experiencing Psychosomatic Symptoms and Fatigue: A Randomized Controlled Trial

An interventional study of Quranic Recitation (Murottal) in Psychosomatic Symptoms and Fatigue Symptom, sponsored by Universitas Indonesia. Completed at 1 site in Indonesia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-22.

Sponsored by Universitas Indonesia · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This randomized controlled trial evaluates the effect of Quranic recitation (murottal) on psychosomatic symptoms and fatigue in adults living with HIV who have psychosomatic symptoms and fatigue. Participants are randomly assigned to either the intervention group, which receives Quranic recitation for approximately 15 minutes, three times per week for 30 days, or the control group. Psychosomatic symptoms and fatigue are assessed before and after the intervention using the Shatri-Sinulingga Psychosomatic Test (SSPT) and Fatigue Severity Scale (FSS), respectively.

02

Conditions studied

  • Psychosomatic Symptoms
  • Fatigue Symptom

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03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

Adults aged ≥18 years. Diagnosed with human immunodeficiency virus (HIV) infection. Muslim. HIV clinical stage 1-2. Undetectable HIV viral load. Shatri-Sinulingga Psychosomatic Test (SSPT) score ≥2. Fatigue Severity Scale (FSS) score ≥36. Willing to participate in the study and provide informed consent.

Exclusion criteria

Exclusion Criteria:

Severe hearing impairment or inability to follow the intervention procedure. Psychotic disorder or depressive disorder requiring psychiatric medication. Pregnancy. Active opportunistic infection. Refusal to participate in the study.

04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    Murottal Quran

    15 mins/ 3 times a week for 30 days

    Behavioral: Quranic Recitation (Murottal)

  • No intervention
    Control

    Standard care without murottal intervention

Interventions

  • BehavioralQuranic Recitation (Murottal)

    Participants receive Quranic recitation (murottal) for approximately 15 minutes, three times per week for 30 days (12 sessions).

05

What researchers measure

Primary outcomes

  1. Change in Shatri-Sinulingga Psychosomatic Test (SSPT) Score

    Time frame: Baseline to 30 days after randomization

  2. Change in Fatigue Severity Scale (FSS) Score

    Time frame: Baseline to 30 days after randomization

06

Study locations

1 site
  • RSUPN Dr. Cipto Mangunkusumo
    Jakarta, DKI Jakarta 10430, Indonesia
07

References and documents

Publications

  • Majidi H, Rajabi-Tavakkol A. A Systematic Review of EEG Studies on the Neural Effects of Quran Listening. Iran J Psychiatry. 2025 Apr;20(2):253-264. doi: 10.18502/ijps.v20i2.18206. PubMed 40521283 ↗
  • Babamohamadi H, Sotodehasl N, Koenig HG, Al Zaben F, Jahani C, Ghorbani R. The Effect of Holy Qur'an Recitation on Depressive Symptoms in Hemodialysis Patients: A Randomized Clinical Trial. J Relig Health. 2017 Feb;56(1):345-354. doi: 10.1007/s10943-016-0281-0. PubMed 27393704 ↗
  • Babamohamadi H, Sotodehasl N, Koenig HG, Jahani C, Ghorbani R. The Effect of Holy Qur'an Recitation on Anxiety in Hemodialysis Patients: A Randomized Clinical Trial. J Relig Health. 2015 Oct;54(5):1921-30. doi: 10.1007/s10943-014-9997-x. PubMed 25559332 ↗
  • Barroso J, Leserman J, Harmon JL, Hammill B, Pence BW. Fatigue in HIV-Infected People: A Three-Year Observational Study. J Pain Symptom Manage. 2015 Jul;50(1):69-79. doi: 10.1016/j.jpainsymman.2015.02.006. Epub 2015 Feb 18. PubMed 25701691 ↗
  • Shatri H, Sinulingga DI, Faisal E, Irvianita V, Putranto R, Ardani Y, Erlita D, Jeger DP, Browijoyo IA. Validity and reliability testing of the Shatri Sinulingga psychosomatic test (SSPT) questionnaire as a screening instrument for psychosomatic disorders in Indonesia. Narra J. 2024 Dec;4(3):e1373. doi: 10.1042/narra.v4i3.1373. Epub 2024 Nov 8. PubMed 39816117 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT07833449
Lead sponsor
Universitas Indonesia
Responsible party
Desty Gusti Sari (Internal Medicine Specialist / Internal Medicine Resident (PPDS), Universitas Indonesia) — Principal investigator
First posted
Sep 22, 2026
Start date
May 20, 2026
Primary completion
Jul 12, 2026
Completion
Jul 12, 2026
Last update
Sep 22, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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