An observational study in Melanoma (Skin Cancer), Basal Cell Carcinoma of Skin and Squamous Cell Cancer of Head and Neck (SCCHN), sponsored by Assuta Medical Center. Completed at 1 site in Israel. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by Assuta Medical Center · Observational
This observational study examines skin cancer among workers who may have prolonged occupational exposure to sunlight. Long-term exposure to ultraviolet radiation from the sun is an important risk factor for several types of skin cancer, particularly among people who work outdoors for many years.
The study will use routinely collected administrative and medical data to describe the characteristics of workers with recognized skin cancer, including age, sex, geographic region, type of skin cancer, occupational characteristics, and disability-related outcomes. Trends over time and differences between population groups will also be evaluated when the available data permit.
The purpose of the study is to better understand the burden of skin cancer associated with occupational sun exposure and to identify groups of workers who may be at increased risk. The findings may help support improved prevention, earlier detection, workplace sun-protection measures, and occupational health policies for outdoor workers.
Occupational exposure to solar ultraviolet radiation is a recognized carcinogenic hazard and is particularly relevant for individuals who spend substantial portions of their working lives outdoors. Chronic cumulative exposure to sunlight may increase the risk of skin malignancies, especially keratinocyte cancers such as squamous-cell carcinoma and basal-cell carcinoma. The relationship between occupational sunlight exposure and melanoma is more complex and will therefore be evaluated separately when diagnostic information permits.
This retrospective observational study will evaluate administrative and medical records of individuals with occupationally relevant skin cancer. The study will characterize the demographic, geographic, occupational, clinical, and disability-related features of affected workers. Available data will be used to examine age and sex distributions, geographic variation, diagnostic categories, patterns over time, and occupational characteristics associated with prolonged outdoor work and potential solar ultraviolet exposure.
Skin cancers will be classified according to the diagnostic information available in the database. Where possible, basal-cell carcinoma, squamous-cell carcinoma, melanoma, and other malignant skin tumors will be evaluated separately because their epidemiology and relationship with ultraviolet radiation differ. Disability-related characteristics, including the type and degree of recognized impairment and whether disability determinations were temporary or permanent, will also be evaluated when available.
Temporal trends will be examined to determine whether the number and proportion of occupational skin-cancer cases changed during the study period. Geographic and demographic differences will also be explored to identify groups with a higher burden of disease. Where appropriate denominators are available, rates will be calculated using the relevant working population as the population at risk. When appropriate population denominators are not available, results will be reported as distributions and proportions of claims rather than population incidence rates.
Because skin cancer generally develops after cumulative ultraviolet exposure over many years, the study will not assume that the year in which a cancer was diagnosed or recognized represents the period during which the relevant occupational exposure occurred. Instead, occupational solar exposure will be considered a long-term cumulative exposure.
The study is intended to improve understanding of the occupational burden of skin cancer among outdoor workers and to identify demographic, geographic, and occupational patterns that may be useful for prevention. Findings may contribute to improved occupational health strategies, including sun-protection policies, worker education, use of protective clothing and sunscreen, reduction of intense midday ultraviolet exposure when feasible, and targeted skin surveillance for workers with prolonged occupational exposure to sunlight.
3,370 studies on the registry are indexed under Melanoma; 578 are open to participants now.
This study's enrollment of 10,000 is above the median of 187 across 488 observational studies indexed under Melanoma.
Browse Melanoma studies →Assuta Medical Center is the lead sponsor of 43 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
-
Workers with documented or recognized skin cancer potentially associated with occupational exposure to solar ultraviolet radiation. The cohort includes individuals with available administrative, occupational, medical, and disability-related records during the study period. Skin cancers will be classified, when data permit, as basal-cell carcinoma, squamous-cell carcinoma, melanoma, or other malignant skin tumors. Demographic characteristics, occupational features, geographic distribution, temporal trends, and disability outcomes will be evaluated. This is an observational study; no intervention or treatment is assigned as part of the study.
Number and Proportion of Recognized Occupational Skin Cancer Cases by Cancer Type
Cancer type was determined at the initial recognition of each occupational skin cancer claim. The number and proportion of recognized cases were summarized by cancer type, including basal-cell carcinoma, squamous-cell carcinoma, melanoma, and other malignant skin tumors, for claims recorded in the national administrative database from January 1, 2018 through December 31, 2025.
Time frame: Baseline (at initial recognition of the occupational skin cancer claim)
Plan to share: No — Individual participant data will not be shared because the study uses confidential administrative, medical, occupational, and disability records that are subject to privacy, ethical, and institutional data-protection restrictions. The investigators are not authorized to distribute individual-level records to external researchers. Study results will be reported only in aggregated or appropriately de-identified form. Additional information regarding the study methodology, statistical analyses, and aggregated results may be made available upon reasonable request, subject to applicable institutional and regulatory requirements.
Ran from Jan 2018 to primary completion in Jul 2026, 102 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Assuta Medical Center