An interventional study of Structured cognitive and cardiovascular interventions in Cognitive Impairment, sponsored by National Heart Centre Singapore. Recruiting at 4 sites in Singapore. Open to participants aged 21 Years to 99 Years. Per ClinicalTrials.gov, last updated 2026-09-21.
Sponsored by National Heart Centre Singapore · Not applicable, Interventional, and Supportive care
This study aims to understand how memory and thinking abilities (cognition) are affected in patients with heart conditions, and to find out if early detection and interventions can improve health outcomes.
Cardiovascular disease (CVD) and cognitive impairment frequently coexist in aging populations and accelerate each other's deterioration through shared vascular and neurobiological pathways.
Primary objectives:
i. To determine the prevalence and profile of cognitive impairment in patients with cardiovascular disease
ii. For the RCT, to compare the proportion of patients who demonstrate improvement in cognitive test scores by 24 weeks between intervention and usual care arms.
Secondary objectives:
i. To evaluate changes in neuropsychological domains (e.g. memory, processing speed), mental health, frailty, and quality of life over time.
ii. To study the association between cognitive status and cardiovascular treatment plan categories.
3,872 studies on the registry are indexed under Cognitive Dysfunction; 1,119 are open to participants now.
This study's planned enrollment of 5,000 is above the median of 64 across 2,794 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →National Heart Centre Singapore is the lead sponsor of 63 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Main Study:
RCT Sub-Study (Mild cognitive impairment (MCI) arm):
Exclusion Criteria:
Note: Pregnant and breast-feeding women may not take part in this study.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Required procedures during baseline visit: i. Blood pressure test ii. Biospecimen collection (Optional) iii. Musculoskeletal analysis iv. Memory test: MoCA and MMSE
Baseline: 1. Cardiovascular measurements:- * Blood pressure test * Echocardiography * Electrocardiography 2. Biospecimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis 5. Cardiopulmonary exercise test (CPET) / Treadmill test (TMX) 6. Magnetic resonance imaging 7. Neuropsychological assessment During Intervention: 12 exercise sessions and 12 cognitive sessions Post-Intervention: 1. Same procedures as Baseline except CPET / TMX 2. Post-intervention questionnaire 3. Qualitative interview (Optional)
Other: Structured cognitive and cardiovascular interventions
Baseline: 1. Cardiovascular measurements:- * Blood pressure test * Echocardiography * Electrocardiography 2. Biospecimen collection 3. Six-minute walk test 4. Musculoskeletal Analysis 5. Cardiopulmonary exercise test (CPET) / Treadmill test (TMX) 6. Magnetic resonance imaging 7. Neuropsychological assessment Post-Intervention: 1. Same procedures as Baseline, except CPET / TMX 2. Post-intervention questionnaire
The intervention arm (RCT R1 cohort) will receive a 24-week multi-component program combining cardiac rehabilitation instruction, cognitive stimulation via a hybrid hospital and home-based telehealth platform.
Primary RCT Outcome
Proportion of participants demonstrating clinically meaningful improvement in cognitive function at 24 weeks, defined as a pre-specified increase in standardized cognitive test scores.
Time frame: 24 weeks
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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National Heart Centre Singapore