An observational study in PostCovid, sponsored by Danderyd Hospital. Completed at 1 site in Sweden. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-05.
Sponsored by Danderyd Hospital · Observational
Since 2020, millions of individuals have been infected with SARS-CoV-2 virus and a substantial proportion continue to experience persistent symptoms that impair functional capacity, limit daily activities, and negatively affect quality of life. The terminology and definitions surrounding this condition remain diverse, such as long COVID, post-COVID-19 syndrome or ongoing symptomatic COVID-19 . In October 2021, the World Health Organization (WHO) introduced the term post-COVID condition (PCC) through a Delphi consensus process defined as:
"As the persistence or onset of new symptoms three months after the initial SARS-CoV-2 infection, with symptoms lasting for at least two months and not explained by alternative diagnoses".
PCC is characterized by a wide range of symptoms, most commonly fatigue, cognitive impairments, muscle weakness, respiratory and cardiac symptoms, and pain often occurring alongside anxiety, depression, and sleep disturbances. Research shows that PCC markedly impairs activities of daily living (ADL), work ability, and overall functioning. Qualitative studies further demonstrate that the combination of physical and cognitive symptoms limits individuals' ability to engage in everyday occupations and reduce work capacity. Consequently, PCC is associated with difficulties in maintaining employment, often resulting in prolonged sick leave, reduced working hours, or the need for workplace accommodations. Given the heterogeneous nature of PCC, its impact on everyday life varies between individuals, highlighting the importance of understanding patients´ own experiences and priorities when planning rehabilitation interventions.
Global efforts have focused on understanding and managing PCC, with rehabilitation emerging as a central strategy. Rehabilitation strategies seem to be a key intervention for improving fatigue, cognitive dysfunction, mood disturbances, and decrease overall well-being; however, current evidence is heterogeneous and insufficient to establish standardized interventions. A lack of research on PCC patients would lead to profound consequences for both patients and society. Without such knowledge, patients' risk of being misdiagnosed or receiving inadequate care, rehabilitation efforts may be ineffective, and healthcare systems will struggle to allocate resources properly. This increases long-term disability, reduces work ability, and places an avoidable burden on individuals and society. Therefore, a deeper understanding of the scope and nature of PCC is essential for understanding this patient group better, developing effective rehabilitation approaches and informing public health policy.
The goal of this observational study is to learn more about the impact of post-COVID condition (PCC) on individuals' everyday occupational performance, cognitive functioning, perceived health, and life satisfaction, with the aim of understanding these patient groups better, and to generate evidence to guide rehabilitation strategies. The research focuses on patients diagnosed with post-COVID condition who are receiving an interprofessional rehabilitation program at a specialized Rehabilitation Clinic in Sweden, Danderyds Hospital,
The main questions aim to answer are:
This is a prospective clinical cohort study, describing occupational performance, cognitive dysfunction and health aspects within patients with post-COVID condition (PCC), which have participated in an interprofessional rehabilitation program. Data collection began in 2021 and continued through 2025. Participants were recruited prior to initiation of rehabilitation and assessed at baseline, immediately post-intervention, and at six-month follow-up.
Setting The study was conducted at the Stockholm Department of Rehabilitation Medicine, Danderyd University Hospital, within the Cognitive Post-COVID Clinic .
Participants Between August 2021 and December 2025, patients with persistent cognitive symptoms and fatigue following mild COVID-19 infection were assessed for eligibility. A total of approximately 100 patients aged 18-65 years were included.
All patients underwent a comprehensive interdisciplinary assessment to determine the need for and potential benefit from interprofessional multimodal rehabilitation (IMR). Only patients who provided written informed consent were enrolled in the study.
Intervention:
Interprofessional Rehabilitation Program The interprofessional rehabilitation program was initiated in spring 2021 and progressively refined based on expanding clinical knowledge of PCC and neurorehabilitation. The program is grounded in principles of chronic pain rehabilitation and neurorehabilitation.
Rehabilitation was delivered in a group-based, in-person format consisting of half-day sessions once weekly for 10 weeks. Participants attended together with other patients with PCC.
Interventions were individually adapted according to participants' energy levels and physical capacity and included:
Procedures Baseline Assessment
Prior to the start of rehabilitation:
Assessments were conducted:
Study Objectives
The planned analyses aim to:
Statistical Analysis and Sample Size The COPM is the primary outcome measure. The study has 90% power to detect a pre-post difference of 2.2 COPM points, assuming a standard deviation of 2.1, a significance level of 5%, and using non-parametric methods, with a sample size of 10 participants.
Non-parametric statistical methods will be applied due to the nature of the data. Spearman's rank correlation will be used for correlation analyses. Logistic regression analyses will be conducted to investigate factors associated with rehabilitation outcomes, including age, sex, and educational level.
541 studies on the registry are indexed under Personal Satisfaction; 93 are open to participants now.
This study's enrollment of 120 is below the median of 180 across 115 observational studies indexed under Personal Satisfaction.
Browse Personal Satisfaction studies →Danderyd Hospital is the lead sponsor of 60 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients aged 18-65 with persistent cognitive symptoms and fatigue following confirmed or strongly suspected COVID-19 infection, who have undergone assessment at the Cognitive Post-COVID Clinic at Danderyd Hospital and subsequently completed a team evaluation prior to participation in interdisciplinary rehabilitation. During the assessment, it is determined whether the patient needs and can benefit from rehabilitation.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Newly developed cognitive impairments or cognitive fatigue.
--A clear temporal link between COVID-19 onset and symptom onset, with symptoms affecting return to previous activities/occupation.
Exclusion Criteria:
The study aims to investigate a cohort of patients with post COVID condition whose primary symptoms are cognitive impairment and fatigue. The patients have undergone a comprehensive assessment by a multiprofessional team and have been deemed both to require and to be capable of participating in an on site interprofessional rehabilitation program conducted one day per week.
Other: Interprofessional cognitive group rehabilitation
The Interprofessional rehabilitation program (IPR) was delivered in a group format, one half day per week over 10 weeks. The interprofessional team comprised an occupational therapist, psychologist, physiotherapist, physician, and social worker. All patients underwent an initial team assessment to determine eligibility for the IRP. Based on this assessment; an individualized rehabilitation plan was developed prior to program initiation. The IPR included lectures, group discussions, and physical activity, with the overall goal of improving daily functioning and facilitating return to work when applicable.
Canadian Occupational Performance Measure (COPM)
The COPM assesses an individual's perceived occupational performance in the areas of self-care, productivity and leisure. Semi-structured interview format and structured scoring method. The person rates/ describes which activities are important for them and after that satisfaction. The person rates importance, performance and satisfaction
Time frame: Before, after and at six months follow-up
EQ5D
The EuroQol 5D (EQ 5D) is a widely used measure of quality of life, the instrument consists of a health index with five dimensions: mobility, self care, usual activities, pain/discomfort, and anxiety/depression. Responses across these dimensions generate a health profile that can be converted into an EQ 5D index score, ranging from 0 (equivalent to death) to 1 (representing perfect health). In addition, the EQ 5D includes a Visual Analog Scale (VAS), on which respondents rate their perceived health status from 0 (worst imaginable health) to 100 (best imaginable health)
Time frame: Before, after and at six month follow-up
HADS
The Hospital Anxiety and Depression Scale (HADS) was developed as a tool for identifying symptoms of anxiety and depression in patients attending hospital medical outpatient clinics, and it has been shown to be reliable for this purpose. Both the anxiety and depression subscales are considered valid indicators of the severity of these emotional disorders.
Time frame: Before, after and six month follow-up
Rand-36
The RAND-36 item health survey is a 36-item questionnaire used as a generic measure of health-related quality of life (HRQoL). It assesses eight health domains: physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to emotional problems, mental health, social functioning, vitality (energy/fatigue), and general health perceptions. Subscale scores range from 0 to 100, with higher scores indicating better health status. The RAND-36 has been translated into Swedish and psychometrically validated for use in the Swedish population.
Time frame: Before, after and a six months follow-up
MFI-20
The Multidimensional Fatigue Inventory (MFI) is a 20-item self-report questionnaire developed to assess fatigue across five dimensions: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity (5).
Time frame: Before, after and at six months follow-up
ISI
The Insomnia Severity Index (ISI) is a self-report questionnaire that assesses perceived insomnia severity. It evaluates subjective symptoms and consequences of insomnia, as well as the level of concern or distress associated with sleep difficulties. The instrument comprises seven items measuring the severity of sleep-onset and sleep-maintenance problems. Each item is rated on a 5-point scale (0-4), yielding a total score ranging from 0 to 28, with higher scores indicating more severe insomnia
Time frame: Before, after and at six month follow-up
WHODAS-12
The World Health Organization Disability Assessment Schedule (WHODAS) is a standardized instrument developed to evaluate disability and activity limitations associated with a wide range of health conditions, including acute and chronic diseases, injuries, mental and emotional disorders, and problems related to alcohol or substance use. WHODAS 12 is the abbreviated version of the 36 item WHODAS 2.0 and is a self administered questionnaire consisting of 12 items. It provides a global assessment of the impact of health conditions on daily functioning over the preceding 30 days
Time frame: Before, after and at six month follow-up
Plan to share: No — Data might be shared on request.
Ran from Aug 2021 to primary completion in Jan 2026, 52 months.
Of 36 non-industry observational studies under Personal Satisfaction, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 28. This study's 52 months is above that.
Counting every sponsor, half of 44 studies reached it within 14 months; a quarter within 4 and three quarters within 29.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Danderyd Hospital