ClinicalTrials.gg
RecruitingNCT078205663DBloodUpdated Sep 15, 2026

Development of a Preclinical 3D Vascularized and Perfused Tumoroid Model in Oncology and Urology Developed From Patient Tumors (Kidney, Bladder, and Prostate Cancers)

An observational study in Kidney Cancers, Bladder Cancer and Prostate Cancer, sponsored by University Hospital, Strasbourg, France. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-15.

Sponsored by University Hospital, Strasbourg, France · Observational

From the registry’s dates

  • Started Sep 2024; still recruiting 2 years 2 months later.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 108 studies in Kidney Neoplasms with a site in France — 31 open to participants now, 36 under way, 4 of them phase 3. Kidney Neoplasms · France.

Planned enrollment
19th of 30
100 · median 163
Started
2024
with 3 others
Observational
30 of 108
7 open now
Primary completion
2029-09
later than 29 of 35 live
Registered
105th of 108
by date
Lead sponsor
4 of 108
University Hospital, Strasbourg, France

Among the 108 studies in Kidney Neoplasms with a site in France, this one is the 19th largest by planned enrollment of the 30 observational ones, is one of 4 that started in 2024, is one of 30 observational ones, reaches primary completion later than 29 of the 35 other live ones, and was the 105th registered.

By phase

108 studies; the count open now beside each. This study's row is marked.

Observationalthis study30 · 7 open
No phase28 · 11 open
Phase 220 · 3 open
Phase 314 · 2 open
Phase 17 · 3 open
Phase 1/25 · 2 open
Phase 43 · 3 open
Phase 2/31 · 0 open

By the year they started

First in 1993; this study’s year is marked. 4 started in 2024.

Size and results

Median enrollment 100 across the 78 interventional studies, 163 across the 30 observational. Of the 58 that completed or were terminated, 17 (29%) have results posted.

Was this useful?
Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 108 studies in Kidney Neoplasms with a site in France, or all of them as a file.
02

Study summary

This is a study :

  • Single-center
  • Prospective
  • Translational
  • Based on data and blood samples. In this context, the aim is to collect approximately 10 ml of blood from each patient included in the 3D tumoroid development project.

The main objective is to establish and validate a panel of vascularized and perfused 3D tumoroids for personalized medicine based on patient tumors for urological cancers, incorporating autologous immune cells.

Translated with DeepL.com (free version)

03

Conditions studied

  • Kidney Cancers
  • Bladder Cancer
  • Prostate Cancer
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

  • Male or female subject (≥18 years old);
  • Diagnosed with kidney cancer, prostate cancer, or bladder cancer;
  • whose tumor tissue and associated data are reused as part of the SphéroUro protocol (study outside the Jardé law, retrospective study on tumor tissue and associated data, from the biobank registered with the Ministry of Education and Research under reference No. DC 2016-2677)

Eligibility criteria

Inclusion Criteria:

Inclusion criteria:

  • Criteria common to all patients:

    • Male or female subject (≥18 years old);
    • Diagnosed with kidney cancer, prostate cancer, or bladder cancer;
    • whose tumor tissue and associated data are reused as part of the SphéroUro protocol (study outside the Jardé law, retrospective study on tumor tissue and associated data, from the biobank registered with the Ministry of Education and Research under reference No. DC 2016-2677);
    • affiliated with a social security health insurance scheme or beneficiary of such a scheme;
    • agreeing to participate in the 3DBlood study.
  • Specific criteria for patients with renal cell carcinoma (RCC):

    • Extended nephrectomy (EN) (larger tumor, closer to the sinus; therefore at greater risk of ): with a cavo, cavectomy (neoplastic thrombus in the vena cava), or renal vein bud, or lymph node dissection, or with adrenalectomy (often for tumors, therefore possible metastases).

Or

- Partial nephrectomy (PN): with tumors at stage T2 or T3a)

Exclusion Criteria:

  • Patient refusal to participate in the study;
  • Inability to provide the subject with (subject in an emergency situation, difficulties in understanding the subject, etc.);
  • Patient under legal protection, guardianship, or conservatorship;
  • Patient currently participating in a therapeutic clinical trial (i.e., gene therapy or other).
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Metastases

Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Interventions

  • BiologicalBlood sample

    An additional 10 ml blood sample taken during a routine blood test

06

What researchers measure

Primary outcomes

  1. Constitute and validate a panel of vascularized and perfused 3D tumoroids for personalized medicine based on patient tumors for urological cancers, incorporating autologous immune cells.

    For the establishment of the models, it is necessary to have: sufficient cell viability after enzymatic dissociation of the tissues and a correspondence of patient/model 3D therapeutic responses. The patients' blood will be collected to isolate immune cells using a Ficoll gradient, to integrate them into the forming 3D structures, taking into account the proportion present in the primary tumor tissues of each patient, for the 3D structures developed from their tumor.

    Time frame: Day 1 after surgery

07

Study locations

1 of 1 sites recruiting
  • Service de Chirurgie Urologique _ Hôpitaux Universitaires de Strasbourg
    Strasbourg, 67091, France
    Recruiting
    • Hervé LANG, PUPH · Contactherve.lang@chru-strasbourg.fr · 33 3 69 55 09 74
    • Hervé LANG, PUPH · Principal investigator
    • Nicolas MEYER, PUPH · Sub investigator
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Sep 2024 (actual). Primary completion is estimated for Sep 2029, 60 months after the start.

Of 89 non-industry observational studies under Kidney Neoplasms, half reached primary completion within 74 months of starting (the median), counting those still running; a quarter within 34. This study's planned 60 months is below that.

Counting every sponsor, half of 107 studies reached it within 74 months; a quarter within 28.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 5, 2026
First posted
Sep 15, 2026
StartActual
Sep 2, 2024
Primary completionEst.
Sep 2029
CompletionEst.
Sep 2029
Last update
Sep 15, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07820566
Responsible party
Sponsor
First posted
Sep 15, 2026
Start date
Sep 2, 2024
Primary completion
Sep 2029 (estimated)
Completion
Sep 2029 (estimated)
Last update
Sep 15, 2026

Study contacts

Hervé LANG, PUPH
Contact
Herve.Lang@chru-strasbourg.fr
33369550974

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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