An interventional study of Pain Neuroscience Education and Standardized Exercise Program in Primary Dysmenorrhea, sponsored by Harran University. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by Harran University · Not applicable, Interventional, and Treatment
Among 81 studies in Dysmenorrhea with a site in Turkey — 19 open to participants now, 23 under way, none of them phase 3. Dysmenorrhea · Turkey.
Among the 81 studies in Dysmenorrhea with a site in Turkey, this one is the 33rd largest by enrollment of the 72 interventional ones that give a count, is one of 13 that started in 2025, is one of 70 with no phase, and was the 79th registered.
430 studies on the registry are indexed under Dysmenorrhea; 107 are open to participants now.
Browse Dysmenorrhea studies →19 of the 81 studies in Dysmenorrhea with a site in Turkey are open now. Recruiting first, the newest first:
Tokat Gaziosmanpasa University · Sites in Turkey
Ages 18+ · Women only · Healthy volunteers
Istanbul Medipol University Hospital · Sites in Turkey
Ages 18–30 · Women only
Ankara University · Sites in Turkey
Ages 18–25 · Women only
Nigde Omer Halisdemir University · Sites in Turkey
Ages 18–30 · Women only · Healthy volunteers
Acibadem University · Sites in Turkey
Ages 10–19 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 57 Dysmenorrhea studies recruiting now, 7 (12%) set no upper age limit and 49 (86%) stop at 75 or younger; 11 take children under 18; 20 take healthy volunteers.
This study: 18 Years to 35 Years · female · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
81 studies; the count open now beside each. This study's row is marked.
First in 2013; this study’s year is marked. 13 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 62 is close to the median of 62 across 363 interventional studies indexed under Dysmenorrhea.
Median enrollment 60 across the 72 interventional studies, 60 across the 9 observational. Of the 52 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 81 has an industry lead sponsor. The 10 most frequent:
Harran University is the lead sponsor of 63 studies on the registry; 22 are open to participants now.
Harran University has 1 study filed under Dysmenorrhea — fewer than ten, so there is no comparison to draw.
3 of the studies in Dysmenorrhea with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07731243Istanbul Medipol University HospitalVibration, Massage, and Myofascial Release in Primary Dysmenorrhea | 2026-11-15 |
| NCT06398990Acibadem UniversityThe Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea | 2026-12 |
| NCT07409337Nigde Omer Halisdemir UniversitySelf-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms | 2026-12-15 |
Among the 81 studies in Dysmenorrhea with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This assessor-blinded, two-arm randomized controlled trial evaluates the additional effects of pain neuroscience education (PNE) when combined with a standardized exercise program in women with primary dysmenorrhea. Sixty-two participants are randomly allocated in a 1:1 ratio to either PNE plus exercise or time-matched routine menstrual-health education plus the same exercise program. Both groups complete a six-week exercise program performed three times weekly, while education is delivered once weekly for six weeks. Outcomes are assessed at baseline, during the first menstrual cycle after the intervention, and approximately three months after intervention completion. The primary outcome is menstrual pain intensity during the first 48 hours of menstruation. Secondary outcomes include activity interference, analgesic use, pain catastrophizing, pressure pain thresholds, conditioned pain modulation, and dynamic pelvic floor ultrasound measures.
430 studies on the registry are indexed under Dysmenorrhea; 107 are open to participants now.
This study's enrollment of 62 is close to the median of 62 across 363 interventional studies indexed under Dysmenorrhea.
Browse Dysmenorrhea studies →Harran University is the lead sponsor of 63 studies on the registry; 22 are open to participants now.
Compared within Dysmenorrhea, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Motor Activity. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants receive pain neuroscience education in addition to the standardized exercise program.
Behavioral: Pain Neuroscience Education · Behavioral: Standardized Exercise Program
Participants receive routine menstrual health education in addition to the same standardized exercise program.
Behavioral: Standardized Exercise Program · Behavioral: Routine Menstrual Health Education
Six weekly 35-45-minute structured educational sessions addressing the protective function of pain, uterine nociception, peripheral and central sensitization, pain modulation, neuroplasticity, attention, expectations, stress, sleep, contextual influences, safe movement, and self-management.
A six-week program performed three times weekly for 18 planned sessions, including aerobic activity, lumbopelvic mobility, trunk and hip strengthening, stretching, diaphragmatic breathing, and relaxation/down-training strategies.
Participants received six weekly 35-45-minute time-matched educational sessions providing routine information about menstruation, menstrual health, lifestyle, and general self-management, without pain neuroscience education content.
Change in Mean Menstrual Pain Intensity During the First 48 Hours of Menstruation
Menstrual pain intensity is recorded using an 11-point Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain), three times daily (morning, afternoon, and evening) during menstrual days 1 and 2. The mean of the six ratings is calculated when at least four valid ratings are available. The primary treatment effect compares change from baseline to the first menstrual cycle following completion of the six-week intervention.
Time frame: Baseline and the first menstrual cycle following completion of the 6-week intervention (T1)
Activity Interference Due to Menstrual Pain
Interference of menstrual pain with daily activities was assessed using an 11-point Numerical Rating Scale (NRS), ranging from 0 (no interference) to 10 (maximum interference), with higher scores indicating greater interference.
Time frame: Baseline, first menstrual cycle following the 6-week intervention (T1), and menstrual cycle closest to 3 months post-intervention
Duration of Menstrual Pain
Interference of menstrual pain with daily activities was assessed using an 11-point Numerical Rating Scale (NRS), ranging from 0 (no interference) to 10 (maximum interference), with higher scores indicating greater interference.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention
Analgesic Use Occasions
The number of occasions on which analgesic medication was used for menstrual pain was recorded during each assessment cycle.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention
Any Analgesic Use
Whether the participant used any analgesic medication for menstrual pain during the assessment cycle was recorded as a dichotomous outcome.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention
School or Work Absence Due to Menstrual Pain
The number of days of absence from school or work attributable to menstrual pain was recorded during each assessment cycle. Higher values indicate greater absenteeism.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention
Pain Catastrophizing Scale Score
Pain-related catastrophic thinking was assessed using the Pain Catastrophizing Scale (PCS), a 13-item self-report measure. Each item is scored from 0 to 4, yielding a total score ranging from 0 to 52. Higher scores indicate greater pain catastrophizing and therefore a worse outcome.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention
Pressure Pain Threshold (PPT)
Pressure pain threshold was assessed using a Commander Echo Algometer (JTECH Medical, Midvale, UT, USA) equipped with a 1 cm² probe at standardized suprapubic, lumbopelvic, and tibialis anterior sites. Higher values indicate lower mechanical pain sensitivity.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention; assessments were performed during both painful and pain-free phases of the menstrual cycle.
Pelvic Floor Mobility Assessed by Transperineal Ultrasound Description:
Pelvic floor mobility was assessed using two-dimensional transperineal ultrasound. Outcomes included cranial excursion during voluntary pelvic floor contraction, caudal excursion during bearing down, and return-to-rest time following the maneuver. Each maneuver was performed three times, and the mean value was used for analysis.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention; assessments were performed during both painful and pain-free phases of the menstrual cycle.
Conditioned Pain Modulation
onditioned pain modulation was assessed using tibialis anterior pressure pain threshold as the test stimulus and contralateral hand immersion in cold water (10 ± 1 °C, maximum 120 seconds) as the conditioning stimulus. The CPM response was calculated from the change in pressure pain threshold during conditioning.
Time frame: Baseline, first menstrual cycle following completion of the 6-week intervention, and menstrual cycle closest to 3 months post-intervention; assessments were performed during both painful and pain-free phases of the menstrual cycle.
Plan to share: No — Individual participant data are not planned to be publicly shared.
No publications or documents are linked to this record.
Ran from Jul 2025 to primary completion in Jun 2026, 11 months.
Of 178 non-industry interventional studies with no phase under Dysmenorrhea, half reached primary completion within 8 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 16. This study's 11 months is above that.
Counting every sponsor, half of 188 studies reached it within 8 months; a quarter within 3 and three quarters within 16.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Harran University