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Not yet recruitingNCT07808801MCS ImpactUpdated Sep 9, 2026

Mental Health Reinforcement in Wayapi and Teko Communities in French Guiana : Evaluation of the Impact of a Mediation Based Activity in Municipalities of Camopi and Trois Saut in French Guiana

An observational study in Mental Disease, sponsored by Centre Hospitalier de Cayenne. Not yet recruiting at 1 site in French Guiana. Open to participants aged 12 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-09.

Sponsored by Centre Hospitalier de Cayenne · Observational

Study type
Observational
Model
Other
Time perspective
Other
Enrollment
300
Ages
12 Years and older
Sex
All
01

Study summary

In French Guiana, Indigenous people experience high levels of psychological distress and higher rates of suicidal behavior than the rest of the population.

The Wayãpi and Teko communities living in Camopi and Trois-Sauts are particularly affected.

Since 2025, Community Workers (CHWs) from these communities have been appointed to facilitate access to care, improve communication between residents and health services, and strengthen support in situations of distress.

To date, no scientific evaluation has been conducted to measure the actual impact of this initiative. This research therefore aims to better understand mental health in these communities and to assess the effect of the community mediators' work.

The results will help improve suicide prevention efforts and adapt public health policies to local realities.

The purpose of this study is to assess the impact of CHWs activities on:

  • suicidal behavior,
  • psychological distress,
  • alcohol use,
  • use of health care services, within the Wayãpi and Teko communities of Camopi and Trois-Sauts.
Read the detailed description

* Rational of the study

The mental health of Indigenous peoples is a major public health and social justice issue. Approximately 370 million Indigenous people live in more than 90 countries, sharing common experiences of historical exclusion, territorial dispossession, and socioeconomic marginalization. These structural determinants result in persistent health inequalities, including suicide rates that are frequently higher than national averages.

International data show significant variability-ranging from 0 to 187.5 suicides per 100,000 people -highlighting the importance of cultural and historical contexts. Ethnicity is not a risk factor in and of itself; vulnerabilities arise from the interaction between historical trauma, socioeconomic conditions, and local cultural dynamics.

The literature highlights three key factors:

  • Structural vulnerability, linked to poverty, discrimination, and limited access to specialized services.
  • Historical and intergenerational trauma linked to colonization, forced displacement, and assimilation policies, which contribute to mental health disorders.
  • Resources for resilience: cultural continuity, local governance, and strong kinship networks.

International comparisons confirm that communities with territorial control, autonomous institutions, or adapted educational systems have significantly lower suicide rates.

The Amazon is a region particularly affected by inequalities in Indigenous mental health. Despite remarkable linguistic and cultural diversity, the region remains marked by the legacy of colonization, resource exploitation, missionary activity, and a chronic lack of health and educational infrastructure.

Available data indicate that suicide rates reach particularly high levels in several Amazonian contexts: up to twenty times the national average among the Guarani-Kaiowá in Brazil, 247.9 per 100,000 inhabitants among the Emberá Dobidá in Colombia, and rates higher than the national average in the Ecuadorian Amazon. These situations reflect the cumulative effect of structural, social, and historical vulnerabilities, the manifestation of which varies according to national and local contexts.

Although it is a department of a high-income country, French Guiana exhibits health inequalities comparable to those observed in low-resource settings. The Amazonian interior, accessible only by canoe or plane, suffers from significant geographic isolation, limiting access to specialized care.

In French Guiana, the municipality of Camopi, which includes the village of Trois-Sauts, has particularly high suicide rates, estimated at 113 and 137 per 100,000 inhabitants, respectively, with suicide attempt rates approaching 400 per 100,000 inhabitants. Suicides primarily affect young people aged 10 to 29, who account for more than 60% of suicide deaths, with an average age of 25 in the interior compared to 36 on the coast.

The observed vulnerabilities result from a complex interplay of factors: alcohol abuse and substance use disorders, domestic violence, a loss of identity due to rapid sociocultural changes, as well as the social and environmental impacts of illegal gold mining. These factors interact within a context of severe social precariousness and the erosion of community structures.

The concentration of psychiatric services in the prefecture and main French Guina town, Cayenne, the language barrier (with Wayãpi and Teko being the predominant languages), and the lack of interventions that are sustainably adapted to Indigenous contexts hinder the effectiveness of existing systems, exacerbating inequalities in access to and care for mental health.

Beyond socioeconomic and health determinants, the situations of psychological distress observed in Wayãpi and Teko communities are embedded in culturally situated frameworks of understanding. Representations of psychological distress, illness, and suicide are inseparable from a relational worldview in which bodily, social, territorial, and symbolic dimensions are closely intertwined.

In this context, psychological distress is not viewed exclusively as an individual disorder, but as an imbalance affecting the relationships between the individual, their social environment, and the symbolic frameworks mobilized to make sense of their lived experience. The failure to take these interpretive frameworks into account in healthcare systems constitutes an additional factor contributing to underutilization of services and the ineffectiveness of interventions.

In many countries, community health workers (CHWs) are a key lever for reducing health inequalities. Their cultural proximity facilitates early detection of health issues, language mediation, psychosocial support, and adherence to care.

In French Guiana, six Wayãpi and Teko Community Health Workers (CHWs) were deployed in 2025 in the municipalities of Camopi and Trois-Sauts. They serve as a bridge between so-called "traditional" medicine and allopathic medicine, facilitating access to care and the management of distressing situations.

Despite these advances, several gaps remain:

  • A lack of standardized epidemiological data on the mental health of the Wayãpi and Teko peoples, aside from suicide mortality.
  • Limited qualitative documentation, particularly regarding perceptions of suffering, addiction, and suicide.
  • A complete lack of scientific evaluation of the role and impact of CHWs in French Guiana. Their effectiveness is assumed by analogy with the Brazilian model but has never been empirically verified.

These gaps hinder the development of appropriate prevention policies and keep the communities' real needs hidden. Three key findings emerge:

  1. Indigenous peoples are disproportionately vulnerable to suicide, with significant variations depending on context.
  2. The Amazon, and French Guiana in particular, is an area with a very high incidence of suicide.
  3. CHWs represent a promising avenue, but require rigorous scientific evaluation.

    • Hypothesis of the study

      • The cultural and linguistic background of the CHWs, who come from the Wayãpi and Teko communities, fosters trust, improves communication, and facilitates access to care, thereby contributing to a reduction in suicidal behaviors.
      • The integration of cultural representations and traditional practices (Tupi-Guarani worldview, rituals, and symbols of suffering) into mediation strengthens individual and collective resilience in the face of mental health disorders.
      • The community mediation model, inspired by the Brazilian Agentes Indígenas de Saúde, is transferable and effective in French Guiana, provided it is adapted to local social, linguistic, and territorial specificities.
      • The close ties between CHWs and their communities are an essential resource for the early detection of crises, but can also lead to emotional overload, requiring appropriate supervision and support.
      • The introduction of CHWs has a measurable positive effect on social cohesion by strengthening community ties, reducing stigma, and facilitating the integration of biomedical care with traditional knowledge.
    • Design of the study

This is a single-center, quasi-experimental, prospective before-and-after study conducted in the municipality of Camopi (including Trois-Sauts).

  • Retrospective phase: analysis of the 5 years preceding the introduction of MCS (aggregated data from institutional records).
  • Inclusion: random selection of participants by drawing households at random from a georeferenced aerial map.
  • Prospective phase: individual longitudinal follow-up over 30 months.
  • Repeated assessments: M0, M12, M24, M30.
  • Mixed-methods approach: standardized quantitative questionnaires (K10, AUDIT-C, WHO SUPRE-MISS/CIDI suicide module) and qualitative investigations (interviews, focus groups).

    * Objectives of the study

  • Primary Objective To evaluate the effectiveness of the CHWs intervention in preventing suicide and reducing suicidal behaviors among the Wayãpi and Teko populations of Camopi and Trois-Sauts.
  • Secondary Objectives

The secondary objectives aim to document the mechanisms, cultural dimensions, and social effects associated with the CHWs' intervention:

  1. Estimate the prevalence of psychological distress and alcohol use among the Wayãpi and Teko communities.
  2. Estimate the use of psychiatric health care services.
  3. Describe cultural representations of distress, suffering, and suicide, as well as the relational and cosmological dynamics mobilized to account for them.
  4. Analyze the role of CHWs as an intercultural interface by documenting how they integrate traditional practices with biomedical care.
  5. Assess the perceived impact of CHWs on social cohesion, the reduction of stigma, and the strengthening of community support resources.
  6. Identify the needs, limitations, working conditions, and burnout factors among CHWs, in order to evaluate the feasibility, sustainability, and conditions for the effectiveness of the program.

    • Benefits

The expected benefits apply to communities, health institutions, and scientific knowledge alike.

For the Wayãpi and Teko communities:

  • improved access to care and early detection of distress
  • reduction of stigma related to mental health
  • strengthening of social cohesion and the integration of traditional healing with biomedicine.

For institutional stakeholders:

  • unprecedented epidemiological data enabling the adaptation of suicide prevention strategies
  • support for the implementation of a structured model of intercultural intervention based on the work of the CHWs
  • improved training for professionals on intercultural approaches.

For research:

  • generation of the first quantitative and qualitative data on the mental health of the Wayãpi and Teko
  • development of a methodological framework that can be applied in other Amazonian context
02

Conditions studied

  • Mental Disease

Keywords

  • Indigenous mental health
  • Suicide prevention
  • Community Health Workers
  • Amazonia / French Guiana
  • Intercultural mediation
03

In context

Mental Disorders

1,740 studies on the registry are indexed under Mental Disorders; 348 are open to participants now.

This study's planned enrollment of 300 is above the median of 220 across 389 observational studies indexed under Mental Disorders.

Browse Mental Disorders studies →

Lead sponsor

Centre Hospitalier de Cayenne is the lead sponsor of 47 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
12 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Adults and children over 12 years of age from the Wayapi and Teko communities in the villages of Camopi and Trois-Saut in French Guiana

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age > 12 years
  • Members of the Wayãpi or Teko communities residing in Camopi or Trois-Sauts.
  • No objection to participating in the study and to the use of their data after receiving information in local languages and in French

Exclusion criteria

Exclusion Criteria:

  • Individuals under legal guardianship
  • Health conditions that prevent them from understanding or completing questionnaires or participating in interviews.
05

Study design

Observational model
Other
Time perspective
Other
Enrollment
300 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the villages of Camopi and Trois-Sauts before and after the deployment of CHWs

    Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the study population, comparing retrospective suicidal behaviour rates in the 5 years before with propective suicidal behaviour rates at 12, 24 and 30 months after the intervention of CHWs among the study population

    Time frame: From inclusion to 12, 24 and 30 months after CHWs intervention

Secondary outcomes

  1. Prevalence of psychological distres

    Measurement of psychological distress score using the validated K10 scale

    Time frame: From inclusion to 12, 24 and 30 months

  2. Prevalence of alcohol use pattern

    Measurement of alcohol use pattern using the validated AUDIT-C scale

    Time frame: From inclusion to 12, 24 and 30 months

  3. Health-care utilisation

    Number of out patient visits and hospitalisations in psychiatric and general medical services

    Time frame: From inclusion to 12, 24 and 30 months

  4. Cultural representations of mental health and CHWs intervention

    Analysis of the cultural representations of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants

    Time frame: From inclusion to 12, 24 and 30 months

  5. Community perceptions of mental health and of CHWs intervention

    Analysis of the community perceptions of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants

    Time frame: From inclusion to 12, 24 and 30 months

  6. Social cohesion and community resilience indicators

    Measurement of the community solidarity and perception of community stigma using individual qualitative questionnaires and focus group strategies

    Time frame: From inclusion to 12, 24 and 30 months

  7. Management needs of CHWs

    Measurement of the level of management and support needed by CHWs in their activities using qualitative questionnaires

    Time frame: At 12, 24 and 30 months

07

Study locations

1 site
08

References and documents

Publications

  • Pollock NJ, Naicker K, Loro A, Mulay S, Colman I. Global incidence of suicide among Indigenous peoples: a systematic review. BMC Med. 2018 Aug 20;16(1):145. doi: 10.1186/s12916-018-1115-6. PubMed 30122155 ↗
  • Pacot R, Garmit B, Pradem M, Nacher M, Brousse P. The problem of suicide among Amerindians in Camopi-Trois Sauts, French Guiana 2008-2015. BMC Psychiatry. 2018 Apr 11;18(1):99. doi: 10.1186/s12888-018-1670-6. PubMed 29642878 ↗
  • Elias B, Mignone J, Hall M, Hong SP, Hart L, Sareen J. Trauma and suicide behaviour histories among a Canadian indigenous population: an empirical exploration of the potential role of Canada's residential school system. Soc Sci Med. 2012 May;74(10):1560-9. doi: 10.1016/j.socscimed.2012.01.026. Epub 2012 Mar 6. PubMed 22464223 ↗
  • Diehl EE, Langdon EJ, Dias-Scopel RP. [The contribution of indigenous community health workers to special healthcare for Brazilian indigenous peoples]. Cad Saude Publica. 2012 May;28(5):819-31. doi: 10.1590/s0102-311x2012000500002. Portuguese. PubMed 22641506 ↗
  • Chandler, M. J., & Lalonde, C. (1998). Cultural Continuity as a Hedge against Suicide in Canada's First Nations. Transcultural Psychiatry, 35(2), 191-219. https://doi.org/10.1177/136346159803500202
  • Burn H, Black J, Harwood M, Gordon I, Burnett AM, Hamm LM, Evans J, Ramke J. Eye care delivery models to improve access to eye care for Indigenous people in high-income countries: protocol for a scoping review. BMJ Open. 2019 Jul 29;9(7):e029214. doi: 10.1136/bmjopen-2019-029214. PubMed 31362967 ↗
  • Agudelo-Hernandez F, Amaya NV, Cardona M. Suicide in a Colombian indigenous community: Beyond mental illness. Int J Soc Psychiatry. 2023 Dec;69(8):1986-1995. doi: 10.1177/00207640231183922. Epub 2023 Jun 30. PubMed 37392003 ↗

Individual participant data

Plan to share: Undecided — Only aggregated data will be shared

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Sep 2026; primary completion for Aug 2029, 35 months later.

Of 149 non-industry observational studies under Mental Disorders, half reached primary completion within 37 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 77. This study's planned 35 months is close to that.

Counting every sponsor, half of 156 studies reached it within 37 months; a quarter within 13 and three quarters within 77.

Mental Disorders covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 2, 2026
First posted
Sep 9, 2026
StartEst.
Sep 1, 2026
Primary completionEst.
Aug 30, 2029
CompletionEst.
Aug 30, 2029
Last update
Sep 9, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07808801
Lead sponsor
Centre Hospitalier de Cayenne
Collaborators
Regional Health Agency (ARS)
Responsible party
Sponsor
First posted
Sep 9, 2026
Start date
Sep 1, 2026 (estimated)
Primary completion
Aug 30, 2029 (estimated)
Completion
Aug 30, 2029 (estimated)
Last update
Sep 9, 2026

Study contacts

Cassio De Figueiredo Azze, MCs
Contact
cassiofr@gmail.com
+33594395050
Mathieu Nacher, MD, PhD
study director · Centre Hospitalier de Cayenne, Inserm CIC 1424 Guyane-Amazonie

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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