An interventional study of Balance training and Sporttherapy in Multiple Sclerosis and Balance, sponsored by Klinik Valens. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-17.
Sponsored by Klinik Valens · Not applicable, Interventional, and Treatment
Among 142 studies in Multiple Sclerosis with a site in Switzerland — 24 open to participants now, 36 under way, 8 of them phase 3. Multiple Sclerosis · Switzerland.
Among the 142 studies in Multiple Sclerosis with a site in Switzerland, this one is the 68th largest by planned enrollment of the 86 interventional ones that give a count, is one of 7 that started in 2026, is one of 28 with no phase, reaches primary completion later than 11 of the 35 other live ones, and was the 140th registered.
3,267 studies on the registry are indexed under Multiple Sclerosis; 662 are open to participants now.
Browse Multiple Sclerosis studies →24 of the 142 studies in Multiple Sclerosis with a site in Switzerland are open now. Recruiting first, the newest first:
Klinik Valens · Sites in Switzerland
Ages 18+
Liliana Barrios · Sites in Switzerland
Ages 18–65 · Healthy volunteers
Prof. Arseny Sokolov, MD, PhD · Sites in Switzerland
Ages 18+
Luzerner Kantonsspital · Sites in Switzerland
Ages 18+
Novartis Pharmaceuticals · Sites in Switzerland, United States, Argentina and 33 more countries
Ages 18–65
A study can be open while its sites in Switzerland have not opened yet or have stopped. Only those recruiting at a site in Switzerland →
Of the 430 Multiple Sclerosis studies recruiting now, 163 (38%) set no upper age limit and 211 (49%) stop at 75 or younger; 40 take children under 18; 96 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
142 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 17 · Phase 3 31 · Phase 4 10
First in 2002; this study’s year is marked. 7 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is above the median of 50 across 2,203 interventional studies indexed under Multiple Sclerosis.
Median enrollment 141 across the 86 interventional studies, 191 across the 56 observational. Of the 96 that completed or were terminated, 37 (39%) have results posted.
This tab as a report to print or save as PDF → With an account.
73 of 142 have an industry lead sponsor. The 10 most frequent:
Klinik Valens is the lead sponsor of 21 studies on the registry; 3 are open to participants now.
Klinik Valens has 9 studies filed under Multiple Sclerosis — fewer than ten, so there is no comparison to draw.
6 of the studies in Multiple Sclerosis with a site in Switzerland that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06141473Phase 3SanofiEfficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis | 2027-05-06 |
| NCT07821411Novartis PharmaceuticalsA Real-World Study of Ofatumumab in Multiple Sclerosis Patients in Germany and Japan | 2026-11-30 |
| NCT06854094Ente Ospedaliero Cantonale, BellinzonaConsolidation Therapy With Cladribine in Relapsing Multiple Sclerosis Patients | 2026-12 |
| NCT05009160Research Center for Clinical Neuroimmunology and Neuroscience BaselDreaMS - Validation Study 1 | 2026-12 |
| NCT05357781Insel Gruppe AG, University Hospital BernImmunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? | 2026-12-30 |
Add all 6 to your calendar (.ics) → With an account.
Among the 142 studies in Multiple Sclerosis with a site in Switzerland, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Balance training is recommended to improve gait stability and mobility. However, there are currently no clearly defined methods for controlling the intensity (challenge) of balance training. This research project aims to determine whether balance training for individuals with multiple sclerosis (MS), individually tailored to the level of difficulty and exertion, is feasible and possible within an inpatient rehabilitation setting. Participants will be randomly assigned to one of two groups: either they will complete group training focusing on strength, endurance, and balance in addition to their regular therapy program, or they will receive individually tailored balance training. Both groups will undergo an initial assessment followed by seven training sessions, each lasting approximately 45-60 minutes. Before discharge, the initial assessments will be repeated. These assessments include completing questionnaires, performing gait tests, balance tests, and a short cognitive test. Interviews will also be conducted with patients and therapists. These are intended to help better assess the feasibility of the training and to gain more insight into the experiences with the training.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The balance training is performed three times per week over a period of three weeks with sessions lasting 45-60 minutes. The intervention is designed to meet the individual needs of pwMS and allows for challenging tasks, while guaranteeing safety by a harnass. During the first training session the appropriate exercise levels that target the adequate intensity are determined (baseline value). Moderate to high-intensive BT in this study is defined as a score of 7-9 points on the rate of perceived stability (RPS) scale and to fulfill the moderate to high-intensive characteristics on the therapists' scale. The intensity of each exercise (level of challenge during the exercise) is monitored and documented for both the therapists and pwMS. According to this feedback, progression is performed by systematically by in- or decreasing difficulty of the exercises.
Other: Balance training
The control group performs a standardized group training session (usual care, UC) that consists of strength, endurance, coordination, balance and mobility exercises. This training is part of standard care at the Rehabilitation Clinic Valens and is therefore not personalized for each participant. The training is performed three times per week over a period of three weeks with sessions lasting 45-60 minutes.
Other: Sporttherapy
The balance training is performed three times per week over a period of three weeks with sessions lasting 45-60 minutes. The intervention is designed to meet the individual needs of pwMS and allows for challenging tasks, while guaranteeing safety by a harnass. During the first training session the appropriate exercise levels that target the adequate intensity are determined (baseline value). Moderate to high-intensive BT in this study is defined as a score of 7-9 points on the rate of perceived stability (RPS) scale and to fulfill the moderate to high-intensive characteristics on the therapists' scale. The intensity of each exercise (level of challenge during the exercise) is monitored and documented for both the therapists and pwMS. According to this feedback, progression is performed by systematically by in- or decreasing difficulty of the exercises.
The control group performs a standardized group training session (usual care, UC) that consists of strength, endurance, coordination, balance and mobility exercises. This training is part of standard care at the Rehabilitation Clinic Valens and is therefore not personalized for each participant. The training is performed three times per week over a period of three weeks with sessions lasting 45-60 minutes.
Balance capacity
Balance capacity measured by the Mini Balance Evaluation system Test (Mini-Best). Measured with a score from 0-28, a higher score indicates a better balance capacity.
Time frame: From enrollment to the end of treatment at 3 weeks.
Cognitive processing speed
Cognitive processing speed is measured with the Symbol Digit Modalities Test (SDMT). Participants receive a sheet with a key of nine numbers (1-9) and symbols shown in pairs. In boxes below only the symbols are shown, and the participants must report the correct corresponding number. The number of correct answers made within 90 seconds is assessed. The oral form of the SDMT is used due to its non-sensitivity to motor disabilities of the upper extremities. Higher scores indicate higher cognitive processing speed.
Time frame: From enrollment to the end of treatment at 3 weeks.
Mobility
Mobility measured by the Timed Up and Go Test (TUG). Measurement in seconds, a lower time indicates a better functional mobility.
Time frame: From enrollment to the end of treatment at 3 weeks.
Complex walking ability
Complex walking ability measured by the Six Spot Step Test (SSST). Measurement in seconds for all trials and for the trials with the dominant and non-dominant leg, a lower time indicates a better complex walking ability.
Time frame: From enrollment to the end of treatment at 3 weeks.
Fatigue
Fatigue measured with the Fatigue Scale for Motor and Cognitive Function (FSMC) Questionnaire. A total score \[20-100\] and a motor and cognitive subscores \[each 10-50\] are calculated, a higher score indicates a higher fatigue.
Time frame: From enrollment to the end of treatment at 3 weeks.
Walking endurance
Walking endurance measured with the 6 Minute Walking Test. Within this test the total distance \[m\], the 2 minute distance \[m\], and the steps \[Number\] and time \[s\] needed for 10 meters are measured.
Time frame: From enrollment to the end of treatment at 3 weeks.
Fear of falling
Fear of falling is measured with the Falls Efficacy Scale-International (FES-I). Participants must answer 16 different questions regarding their fear of falling during activities of daily life. For each item the level of fear is assessed on a 4-point scale (from 1="not at all" to 4="very"). Scores range from 16-64, with higher scores indicating a higher fair of falling during daily activities.
Time frame: From enrollment to the end of treatment at 3 weeks
Health related quality of life
Health related quality of life is measured with the Patient Reported Outcomes Measurement Information System-10 (PROMIS-10). They score each item on a 5-point scale and rate their pain from 0 to 10. The score is summarized to a mental and a physical health score, each from 0-20. With low scores indicating poor perceived health related quality of life.
Time frame: From enrollment to the end of treatment at 3 weeks
Plan to share: No
No publications or documents are linked to this record.
Started May 2026 (actual). Primary completion is estimated for Dec 2027, 19 months after the start.
Of 848 non-industry interventional studies with no phase under Multiple Sclerosis, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 43. This study's planned 19 months is below that.
Counting every sponsor, half of 870 studies reached it within 21 months; a quarter within 9 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
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Klinik Valens