An interventional study of Desflurane and Sevoflurane in Postoperative Cognitive Dysfunction (POCD) and Controlled Hypotension for Nasal Surgeries, sponsored by Dr. Lutfi Kirdar Kartal Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by Dr. Lutfi Kirdar Kartal Training and Research Hospital · Not applicable, Interventional, and Other
This randomized prospective study aimed to compare desflurane, sevoflurane, and total intravenous anesthesia methods in patients undergoing elective ear surgery under controlled hypotension, with a particular focus on postoperative cognitive dysfunction. In addition to cognitive outcomes, intraoperative hemodynamic parameters, cerebral oxygenation, and perioperative clinical outcomes were evaluated and compared among the three groups.
Controlled hypotension is commonly used in ear surgery to reduce intraoperative bleeding and improve the surgical field. However, the effects of different anesthetic maintenance techniques used during controlled hypotension on postoperative cognitive function remain unclear.
This prospective randomized study included adult patients undergoing elective ear surgery. Patients were randomly assigned to receive desflurane, sevoflurane, or total intravenous anesthesia for maintenance of anesthesia under controlled hypotension.
The primary objective of the study was to evaluate postoperative cognitive dysfunction. Secondary objectives included comparison of intraoperative hemodynamic stability, cerebral oxygenation, and perioperative clinical outcomes among the three anesthesia techniques.
Hemodynamic parameters and cerebral oxygen saturation were recorded at predefined time points during the intraoperative period. Postoperative cognitive function was assessed using standardized cognitive evaluation methods.
The findings of this study aim to contribute to the selection of optimal anesthetic techniques in ear surgery performed under controlled hypotension.
Exclusion Criteria:
Desflurane-Remifentanil Group
Drug: Desflurane · Drug: Remifentanil
Patients received general anesthesia with sevoflurane for maintenance and remifentanil infusion.
Drug: Sevoflurane · Drug: Remifentanil
Patients received total intravenous anesthesia with propofol and remifentanil infusion.
Drug: Remifentanil · Drug: Propofol (Astra-Zeneca)
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Postoperative cognitive function (POCD)
Postoperative cognitive function was evaluated using standardized neurocognitive tests before surgery and on postoperative day 7. Changes from baseline were analyzed to assess postoperative cognitive dysfunction.
Time frame: Preoperative baseline and postoperative day 7
Intraoperative cerebral oxygen saturation (rSO2)
Regional cerebral oxygen saturation (rSO2) was continuously monitored intraoperatively using near-infrared spectroscopy (NIRS) and compared between groups at predefined time points.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Mean Arterial Pressure
Mean arterial pressure (MAP) was recorded intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Arterial Partial Pressure of Oxygen
Arterial partial pressure of oxygen (PaO₂) was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Heart Rate
Heart rate (HR) was recorded intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Arterial Partial Pressure of Carbon Dioxide
Arterial partial pressure of carbon dioxide (PaCO₂) was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Blood Lactate Level
Blood lactate level was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Plan to share: No
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Postoperative Cognitive Complications→
Dr. Lutfi Kirdar Kartal Training and Research Hospital