An interventional study of Desflurane and Sevoflurane in Postoperative Cognitive Dysfunction (POCD) and Controlled Hypotension for Nasal Surgeries, sponsored by Dr. Lutfi Kirdar Kartal Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by Dr. Lutfi Kirdar Kartal Training and Research Hospital · Not applicable, Interventional, and Other
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Among 32 studies in Postoperative Cognitive Complications with a site in Turkey — 6 open to participants now, 8 under way, none of them phase 3. Postoperative Cognitive Complications · Turkey.
Among the 32 studies in Postoperative Cognitive Complications with a site in Turkey, this one is the 8th largest by enrollment of the 13 interventional ones that give a count, is one of 6 that started in 2023, is one of 12 with no phase, and was the 28th registered.
260 studies on the registry are indexed under Postoperative Cognitive Complications; 55 are open to participants now.
Browse Postoperative Cognitive Complications studies →6 of the 32 studies in Postoperative Cognitive Complications with a site in Turkey are open now. Recruiting first, the newest first:
Fatihhan Zeytun · Sites in Turkey
Ages 18+ · Women only
Muğla Sıtkı Koçman University · Sites in Turkey
Ages 65+
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Sites in Turkey
Ages 18–65
Bursa Yuksek Ihtisas Training and Research Hospital · Sites in Turkey
Ages 18–80
Ankara City Hospital Bilkent · Sites in Turkey
Ages 18–40 · Women only · Healthy volunteers
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 34 Postoperative Cognitive Complications studies recruiting now, 22 (65%) set no upper age limit and 4 (12%) stop at 75 or younger; 2 take children under 18; 6 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
32 studies; the count open now beside each. This study's row is marked.
First in 2017; this study’s year is marked. 6 started in 2023.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 69 is below the median of 107 across 145 interventional studies indexed under Postoperative Cognitive Complications.
Median enrollment 80 across the 13 interventional studies, 80 across the 19 observational. Of the 21 that completed or were terminated, 0 (0%) have results posted.
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None of the 32 has an industry lead sponsor. The 10 most frequent:
Dr. Lutfi Kirdar Kartal Training and Research Hospital is the lead sponsor of 78 studies on the registry; 9 are open to participants now.
Dr. Lutfi Kirdar Kartal Training and Research Hospital has 1 study filed under Postoperative Cognitive Complications — fewer than ten, so there is no comparison to draw.
1 of the studies in Postoperative Cognitive Complications with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07339124Ankara Ataturk Sanatorium Training and Research HospitalThe Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients | 2027-03-15 |
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Among the 32 studies in Postoperative Cognitive Complications with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This randomized prospective study aimed to compare desflurane, sevoflurane, and total intravenous anesthesia methods in patients undergoing elective ear surgery under controlled hypotension, with a particular focus on postoperative cognitive dysfunction. In addition to cognitive outcomes, intraoperative hemodynamic parameters, cerebral oxygenation, and perioperative clinical outcomes were evaluated and compared among the three groups.
Controlled hypotension is commonly used in ear surgery to reduce intraoperative bleeding and improve the surgical field. However, the effects of different anesthetic maintenance techniques used during controlled hypotension on postoperative cognitive function remain unclear.
This prospective randomized study included adult patients undergoing elective ear surgery. Patients were randomly assigned to receive desflurane, sevoflurane, or total intravenous anesthesia for maintenance of anesthesia under controlled hypotension.
The primary objective of the study was to evaluate postoperative cognitive dysfunction. Secondary objectives included comparison of intraoperative hemodynamic stability, cerebral oxygenation, and perioperative clinical outcomes among the three anesthesia techniques.
Hemodynamic parameters and cerebral oxygen saturation were recorded at predefined time points during the intraoperative period. Postoperative cognitive function was assessed using standardized cognitive evaluation methods.
The findings of this study aim to contribute to the selection of optimal anesthetic techniques in ear surgery performed under controlled hypotension.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Desflurane-Remifentanil Group
Drug: Desflurane · Drug: Remifentanil
Patients received general anesthesia with sevoflurane for maintenance and remifentanil infusion.
Drug: Sevoflurane · Drug: Remifentanil
Patients received total intravenous anesthesia with propofol and remifentanil infusion.
Drug: Remifentanil · Drug: Propofol (Astra-Zeneca)
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Used for maintenance of anesthesia.
Postoperative cognitive function (POCD)
Postoperative cognitive function was evaluated using standardized neurocognitive tests before surgery and on postoperative day 7. Changes from baseline were analyzed to assess postoperative cognitive dysfunction.
Time frame: Preoperative baseline and postoperative day 7
Intraoperative cerebral oxygen saturation (rSO2)
Regional cerebral oxygen saturation (rSO2) was continuously monitored intraoperatively using near-infrared spectroscopy (NIRS) and compared between groups at predefined time points.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Mean Arterial Pressure
Mean arterial pressure (MAP) was recorded intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Arterial Partial Pressure of Oxygen
Arterial partial pressure of oxygen (PaO₂) was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Heart Rate
Heart rate (HR) was recorded intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: Preoperative baseline (T0); 5, 15, 30, 45, and 60 minutes after intubation (T1-T5); and 5 and 15 minutes after extubation (T6-T7).
Arterial Partial Pressure of Carbon Dioxide
Arterial partial pressure of carbon dioxide (PaCO₂) was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Blood Lactate Level
Blood lactate level was measured intraoperatively at predefined time points and compared between the three anesthesia groups.
Time frame: 15 minutes (T2) and 60 minutes (T5) after intubation.
Plan to share: No
No publications or documents are linked to this record.
Ran from Dec 2023 to primary completion in Jul 2024, 7 months.
Of 63 non-industry interventional studies with no phase under Postoperative Cognitive Complications, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 33. This study's 7 months is below that.
Counting every sponsor, half of 63 studies reached it within 16 months; a quarter within 8 and three quarters within 33.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Desflurane · Sevoflurane · Propofol
Postoperative Cognitive Complications →
Dr. Lutfi Kirdar Kartal Training and Research Hospital