An interventional study of Mandala Coloring in Psychological Resilience Among Midwives Working in Delivery Rooms, sponsored by Istanbul University - Cerrahpasa. Completed at 8 sites in Turkey (Türkiye). Open to female participants, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-28.
Sponsored by Istanbul University - Cerrahpasa · Not applicable, Interventional, and Supportive care
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Among 340 studies in Depression with a site in Turkey — 59 open to participants now, 70 under way, none of them phase 3. Depression · Turkey.
Among the 340 studies in Depression with a site in Turkey, this one is the 60th largest by enrollment of the 244 interventional ones that give a count, is one of 59 that started in 2025, is one of 237 with no phase, and was the 316th registered.
8,582 studies on the registry are indexed under Depression; 1,723 are open to participants now.
Browse Depression studies →59 of the 340 studies in Depression with a site in Turkey are open now. Recruiting first, the newest first:
Istanbul Nisantasi University · Sites in Turkey
Ages 18+ · Healthy volunteers
Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Sites in Turkey
Ages 18–65
Istanbul University · Sites in Turkey
Ages 18+
Istanbul University - Cerrahpasa · Sites in Turkey
Ages 40–54 · Women only · Healthy volunteers
Selcuk University · Sites in Turkey
Ages 18+ · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 1,089 Depression studies recruiting now, 470 (43%) set no upper age limit and 519 (48%) stop at 75 or younger; 203 take children under 18; 311 take healthy volunteers.
This study: female · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
340 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 59 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 91 is above the median of 81 across 7,066 interventional studies indexed under Depression.
Median enrollment 60 across the 244 interventional studies, 105 across the 96 observational. Of the 256 that completed or were terminated, 6 (2%) have results posted.
This tab as a report to print or save as PDF → With an account.
6 of 340 have an industry lead sponsor. The 10 most frequent:
Istanbul University - Cerrahpasa is the lead sponsor of 701 studies on the registry; 211 are open to participants now.
Istanbul University - Cerrahpasa has 6 studies filed under Depression — fewer than ten, so there is no comparison to draw.
24 of the studies in Depression with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07846410Istanbul Physical Medicine Rehabilitation Training and Research HospitalVirtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury | 2026-11 |
| NCT07444697Kırıkkale University"Erectile Function After PCI in MI and Non-MI Patients" | 2026-11 |
| NCT07906119Saglik Bilimleri UniversitesiAcceptance and Commitment Therapy-Based Group Psychotherapy for Chronic Headache | 2026-11-19 |
| NCT07517549Ordu UniversitySexual Health Education During Pregnancy | 2026-11-30 |
| NCT07718399Halic UniversitySpirulina Supplementation in Postmenopausal Women | 2026-12 |
Add all 24 to your calendar (.ics) → With an account.
Among the 340 studies in Depression with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Midwives working in delivery rooms are exposed to occupational and psychological stressors associated with high workloads, shift work, time pressure, obstetric emergencies, and traumatic perinatal events. These working conditions may adversely affect their psychological resilience and well-being. Mandala coloring is a simple, low-cost, art-based activity that may promote relaxation and psychological well-being; however, evidence regarding its effect on psychological resilience among midwives is limited.
The aim of this study was to evaluate the effect of mandala coloring on psychological resilience among midwives working in delivery rooms. Secondary outcomes included depression, anxiety, stress, and psychological well-being.
The study was conducted as a two-arm, pretest-posttest, matched cluster randomized controlled trial involving midwives working in the delivery rooms of eight hospitals. Hospitals were treated as clusters and matched into four pairs according to the number of midwives working in the delivery room and the annual number of births. Within each matched pair, one hospital was randomly assigned to the intervention group and the other to the control group. A total of 91 midwives participated in the study, with 45 midwives from four hospitals allocated to the intervention group and 46 midwives from four hospitals allocated to the control group.
Midwives in the intervention group participated in a six-week mandala coloring program. They were asked to complete two mandala coloring sessions per week, for a total of 12 sessions, with each session lasting approximately 20-30 minutes. Participants in the control group continued their usual routines during the six-week study period.
Psychological resilience was assessed as the primary outcome using the Resilience Scale for Adults. Depression, anxiety, and stress were assessed using the Depression Anxiety Stress Scale-21, and psychological well-being was assessed using the Psychological Well-Being Scale. Outcomes were assessed at baseline and at the end of the six-week intervention period.
Midwives working in delivery rooms may be exposed to substantial occupational and psychological stressors due to high workloads, shift work, time pressure, obstetric emergencies, and exposure to traumatic perinatal events. These demands may adversely affect their psychological well-being and resilience. Psychological resilience is particularly important for midwives because it may support their ability to adapt to stressful working conditions while maintaining professional functioning and well-being.
Art-based activities have been investigated as non-pharmacological approaches for reducing psychological distress and promoting well-being. Mandala coloring is a structured art-based activity involving the coloring of repetitive and geometric patterns. It is inexpensive, easy to implement, requires minimal resources, and can potentially be incorporated into workplace settings without extensive training.
Previous studies have suggested that mandala-based interventions may have beneficial effects on outcomes such as stress, anxiety, psychological well-being, and coping in different populations. However, evidence regarding the effect of mandala coloring specifically on psychological resilience remains limited and inconsistent. Furthermore, there is limited evidence evaluating mandala coloring as a workplace-based intervention among midwives working in delivery rooms.
This study was therefore designed to evaluate whether a six-week mandala coloring intervention could improve psychological resilience among midwives working in delivery rooms. The study also examined the effects of the intervention on depression, anxiety, stress, and psychological well-being as secondary outcomes. By evaluating a simple, low-cost, and easily applicable intervention within the clinical work environment, the study aimed to contribute evidence regarding strategies that may support the psychological well-being of midwives.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm completed a six-week mandala coloring intervention. They were instructed to color a mandala twice per week for approximately 20-30 minutes per session, resulting in a total of 12 planned sessions. Participants selected a mandala design and colored it according to their own preferences. Adherence was monitored by asking participants to notify the researcher before each session and to send a photograph of the completed mandala after each session. Reminder messages were sent twice weekly.
Behavioral: Mandala Coloring
Participants in this arm continued their usual routines and did not receive the mandala coloring intervention during the six-week study period. They were contacted twice weekly to determine whether they had engaged in any relaxation or stress-reducing activities during the study period. After completion of the final assessment, participants were provided with information about mandala coloring and were offered the opportunity to engage in the activity.
Participants completed mandala coloring twice per week for six consecutive weeks, for a total of 12 sessions. Each session lasted approximately 20-30 minutes and was conducted during working hours at a time suitable for the participant. Participants selected one of the provided mandala designs and colored it according to their own preferences using a 12-color felt-tip pen set. Adherence was monitored through messages sent before each session and photographs of the completed mandalas sent to the researcher after each session. Reminder messages were sent twice weekly.
Resilience Scale for Adults (RSA)
Psychological resilience was assessed using the Resilience Scale for Adults (RSA). The scale consists of 33 items and yields a total score ranging from 33 to 165. Higher scores indicate higher levels of psychological resilience. The primary outcome was the change in the total RSA score from baseline to the end of the six-week intervention.
Time frame: Baseline and immediately after the 6-week intervention
Depression Anxiety Stress Scale-21 (DASS-21)
The scale is a 21-item self-report instrument used to assess symptoms of depression, anxiety, and stress. It consists of three sub-dimensions: depression, anxiety, and stress, with seven items in each sub-dimension. Items are rated from 0 to 3, with a raw score ranging from 0 to 21 for each sub-dimension. Higher scores indicate a higher level of depression, anxiety, or stress symptoms in that sub-dimension.
Time frame: Baseline and immediately after the 6-week intervention
Psychological Well-Being Scale
Psychological well-being was assessed using the 8-item Psychological Well-Being Scale. Total scores range from 8 to 56, with higher scores indicating greater psychological well-being.
Time frame: Baseline and immediately after the 6-week intervention
Plan to share: No — Data are available from the corresponding author upon reasonable request
No publications or documents are linked to this record.
Ran from Jan 2025 to primary completion in Aug 2025, 7 months.
Of 3,471 non-industry interventional studies with no phase under Depression, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 41. This study's 7 months is below that.
Counting every sponsor, half of 3,569 studies reached it within 21 months; a quarter within 9 and three quarters within 41.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Istanbul University - Cerrahpasa →