An interventional study of Vertically coronally advanced flap (V-CAF) in Gingival Recession and Gum Recession, sponsored by University of Medicine and Pharmacy at Ho Chi Minh City. Active, not recruiting at 1 site in Vietnam. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by University of Medicine and Pharmacy at Ho Chi Minh City · Not applicable, Interventional, and Treatment
The purpose of this clinical trial is to evaluate the effectiveness of a modified surgical technique called the vertically coronally advanced flap (V-CAF) combined with a connective tissue graft and tissue regeneration for treating gingival recession. For more severe cases (Miller Class III), the study investigates the relationship between the pre-operative Coronally Advanced Flap Difficulty Score (CAFDS) and post-operative outcomes, such as the root coverage rate and interdental papilla height. Participants will undergo the assigned surgical treatment and will be followed up at 3, 6, and 12 months to assess healing and tissue stability.
Gingival recession is a condition that causes root exposure, which can lead to dentin hypersensitivity and aesthetic concerns.
Initially, the study describes the clinical characteristics and factors associated with gingival recession utilizing clinical examinations, 3D intraoral scans, and Cone Beam Computed Tomography (CBCT).
The interventional surgical phase is the single-arm clinical trial involving Twenty-five Miller Class III gingival recession sites. This phase evaluates the correlation between the pre-operative Coronally Advanced Flap Difficulty Score (CAFDS) and clinical outcomes, specifically evaluating the root coverage percentage and interdental papilla height using the V-CAF technique. Standardized clinical parameters, including Recession Depth (RD), Keratinized Tissue (KT) height, Gingival Thickness (GT), Vestibular Depth (RVD), and the Root Coverage Esthetic Score (RES) will be recorded. Data will be collected at baseline (T0), 3 months (T3), 6 months (T6), and 12 months (T12) post-surgery to conduct comparative analyses.
426 studies on the registry are indexed under Gingival Recession; 106 are open to participants now.
This study's enrollment of 25 is below the median of 30 across 390 interventional studies indexed under Gingival Recession.
Browse Gingival Recession studies →University of Medicine and Pharmacy at Ho Chi Minh City is the lead sponsor of 127 studies on the registry; 44 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants with Miller Class III gingival recession receiving the vertically coronally advanced flap (V-CAF) procedure
Procedure: Vertically coronally advanced flap (V-CAF)
A surgical procedure utilizing a vertically coronally advanced flap combined with an autogenous connective tissue graft and tissue regeneration materials to treat gingival recession.
Mean Root Coverage (MRC)
The mean percentage of root surface coverage achieved following treatment, assessed by measuring the root coverage area on intraoral scan files using digital measurement software
Time frame: Baseline, 3 months, and 6 months after surgery
Coronally Advanced Flap Difficulty Score (CAFDS)
The Coronally Advanced Flap Difficulty Score (CAFDS) will be used to assess the anatomical difficulty of treating gingival recession defects with a coronally advanced flap. The score consists of eight anatomical parameters: papilla anatomy, apical keratinized tissue width, lateral keratinized tissue width, apical frenum, lateral frenum, vestibular depth, mucosal invagination, and scar tissue. Each parameter is assessed and assigned a predefined score according to the CAFDS system, with higher scores indicating greater surgical difficulty.
Time frame: Baseline (T0), before surgery
Gingival Recession Depth (RD)
The distance from the cementoenamel junction (CEJ) to the free gingival margin (FGM)
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Gingival Recession Width (RW)
The horizontal distance between the two intersection points of the free gingival margin and the cementoenamel junction (CEJ)
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Base of the Interdental Papilla (IPb)
A linear segment connecting the most apical points of the CEJ of the two adjacent teeth, intersecting the interdental papilla
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Interdental Papilla Height (IPh)
The vertical distance from the base of the interdental papilla to the tip of the interdental papilla
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Interdental Papilla Width (IPw)
The length of a horizontal line parallel to the base of the interdental papilla, located 2 mm apical to the papillary tip
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Keratinized Tissue Height (KT)
The apicocoronal dimension of the keratinized gingival tissue
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Gingival Thickness (GT)
The horizontal distance from the gingival surface to the root/alveolar bone surface, measured at 2 mm apical to the free gingival margin
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Vestibular Depth (RVD)
The vertical distance from the free gingival margin to the depth of the vestibule
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Root Coverage Esthetic Score (RES)
The professional esthetic evaluation score of the root coverage outcome
Time frame: 3 months, 6 months, and 12 months post-operative (T3, T6, T12)
Area of Gingival Recession
The total exposed root surface area
Time frame: Baseline, 3 months, 6 months, and 12 months post-operative (T0, T3, T6, T12)
Plan to share: No
No publications or documents are linked to this record.
Started Feb 2025 (actual). Primary completion is estimated for Dec 2026, 22 months after the start.
Of 233 non-industry interventional studies with no phase under Gingival Recession, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 30. This study's planned 22 months is above that.
Counting every sponsor, half of 235 studies reached it within 19 months; a quarter within 11 and three quarters within 30.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Medicine and Pharmacy at Ho Chi Minh City →