An interventional study of Low-Level Laser Therapy (LLLT) and Paraffin Bath Therapy in Carpal Tunnel Syndrome (CTS), sponsored by Bursa Yuksek Ihtisas Training and Research Hospital. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Bursa Yuksek Ihtisas Training and Research Hospital · Not applicable, Interventional, and Treatment
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Among 128 studies in Carpal Tunnel Syndrome with a site in Turkey — 35 open to participants now, 39 under way, none of them phase 3. Carpal Tunnel Syndrome · Turkey.
Among the 128 studies in Carpal Tunnel Syndrome with a site in Turkey, this one is the 6th largest by planned enrollment of the 81 interventional ones that give a count, is one of 18 that started in 2026, is one of 74 with no phase, reaches primary completion later than 32 of the 38 other live ones, and was the 123rd registered.
589 studies on the registry are indexed under Carpal Tunnel Syndrome; 134 are open to participants now.
Browse Carpal Tunnel Syndrome studies →35 of the 128 studies in Carpal Tunnel Syndrome with a site in Turkey are open now. Recruiting first, the newest first:
Izmir Bakircay University · Sites in Turkey
Ages 18–60
Izmir Bakircay University · Sites in Turkey
Ages 18–60
Haydarpasa Numune Training and Research Hospital · Sites in Turkey
Ages 18–75
Istanbul University · Sites in Turkey
Ages 18–65
Ankara University · Sites in Turkey
Ages 18+
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 73 Carpal Tunnel Syndrome studies recruiting now, 27 (37%) set no upper age limit and 37 (51%) stop at 75 or younger; 1 takes children under 18; 10 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
128 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 18 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 105 is above the median of 60 across 444 interventional studies indexed under Carpal Tunnel Syndrome.
Median enrollment 60 across the 81 interventional studies, 84 across the 47 observational. Of the 82 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 128 has an industry lead sponsor. The 10 most frequent:
Bursa Yuksek Ihtisas Training and Research Hospital is the lead sponsor of 53 studies on the registry; 23 are open to participants now.
Bursa Yuksek Ihtisas Training and Research Hospital has 1 study filed under Carpal Tunnel Syndrome — fewer than ten, so there is no comparison to draw.
10 of the studies in Carpal Tunnel Syndrome with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07327723Ankara UniversityEffects of Repetitive Peripheral Magnetic Stimulation(rPMS) on CTS(Carpal Tunnel Syndrome) | 2026-12-15 |
| NCT07522060Hacettepe UniversityEarly Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System | 2026-12-30 |
| NCT07847450Bezmialem Vakif UniversityMeasurement of Muscle Strength Using a Manual Muscle Tester in Women With Electrophysiologically Confirmed Carpal Tunnel Syndrome | 2027-01 |
| NCT07359274Kutahya Health Sciences UniversityEffects of Neurodynamic and Carpal Bone Mobilization in Mild-to-Moderate Carpal Tunnel Syndrome | 2027-01-15 |
| NCT07788248Bursa Yuksek Ihtisas Training and Research HospitalLow-Level Laser Therapy for Carpal Tunnel Syndrome | 2027-02-01 |
Add all 10 to your calendar (.ics) → With an account.
Among the 128 studies in Carpal Tunnel Syndrome with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy, caused by compression of the median nerve within the carpal tunnel at the wrist. It typically presents with paresthesia, numbness, and pain in the median nerve distribution, and in advanced cases may lead to thenar atrophy and reduced grip strength. Conservative treatment options for mild-to-moderate CTS include wrist splinting, exercise programs, and physical therapy modalities such as low-level laser therapy (LLLT) and paraffin bath therapy; however, the comparative efficacy of these modalities has not been well established.
This study aims to compare the efficacy of low-level laser therapy (LLLT), paraffin bath therapy, and sham LLLT, each combined with standard conservative care (night wrist splinting and tendon/nerve gliding exercises), in patients with mild-to-moderate CTS. Participants will be randomly assigned in a 1:1:1 ratio to receive LLLT, paraffin bath therapy, or sham LLLT, each administered 5 days/week for 3 weeks (15 sessions), in addition to wrist splinting and a home exercise program continued throughout the study.
The primary outcome is the change in symptom severity and functional status, assessed using the Symptom Severity Scale (SSS) and Functional Status Scale (FSS) of the Boston Carpal Tunnel Questionnaire. Secondary outcomes include electrophysiological parameters from median nerve conduction studies, median nerve cross-sectional area on ultrasonography, grip and pinch strength, pain (Visual Analog Scale), and hand function (QuickDASH). Assessments will be performed before treatment, immediately after completing 15 sessions, and at 3 months after treatment completion. Outcome assessors will be blinded to treatment allocation.
The investigators hypothesize that LLLT will result in greater improvement in clinical, electrophysiological, and morphological parameters compared with sham LLLT, and will provide comparative data on its efficacy relative to paraffin bath therapy.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will receive active low-level laser therapy in addition to standard conservative care (night wrist splinting and home exercise program).
Device: Low-Level Laser Therapy (LLLT) · Other: Standard Conservative Care
Participants in this arm will receive paraffin bath therapy in addition to standard conservative care (night wrist splinting and home exercise program).
Device: Paraffin Bath Therapy · Other: Standard Conservative Care
Participants in this arm will receive sham low-level laser therapy (identical device, duration, and application sites, without therapeutic energy output) in addition to standard conservative care (night wrist splinting and home exercise program).
Device: Sham Low-Level Laser Therapy · Other: Standard Conservative Care
Active LLLT applied at 670 nm wavelength at 5 points along the carpal tunnel and flexor retinaculum at the wrist level, delivering 0.8 J per point (4 J per session), administered once daily, 5 days/week, for 3 weeks (15 sessions total). Arms assigned: Arm 1 (LLLT Group)
Also known as: BTL LLLT device
The hand is dipped into a container of melted paraffin, removed, and the paraffin layer is left in place for approximately 20 minutes before being peeled off. Administered once daily, 5 days/week, for 3 weeks (15 sessions total). Arms assigned: Arm 2 (Paraffin Group)
Also known as: Zirvemed paraffin device
The same laser device, application sites, and session duration as active LLLT will be used, but without therapeutic energy output, administered once daily, 5 days/week, for 3 weeks (15 sessions total). Arms assigned: Arm 3 (Sham LLLT Group)
Also known as: Sham BTL LLLT device
All participants will continue a home exercise program consisting of tendon and median nerve gliding exercises, along with regular use of a night wrist splint, from enrollment until the final study assessment. Arms assigned: Arm 1, Arm 2, Arm 3 (all arms)
Change from Baseline in Boston Carpal Tunnel Questionnaire - Symptom Severity Scale (SSS)
Symptom severity will be assessed using the Turkish-validated Symptom Severity Scale of the Boston Carpal Tunnel Questionnaire. Higher scores indicate greater symptom severity. Unit of Measure: score
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in Boston Carpal Tunnel Questionnaire - Functional Status Scale (FSS)
Functional status will be assessed using the Turkish-validated Functional Status Scale of the Boston Carpal Tunnel Questionnaire. Higher scores indicate greater functional impairment. Unit of Measure: score
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in Median Sensory Nerve Action Potential Amplitude
Assessed via median sensory nerve conduction study. Unit of Measure: microvolts (µV)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Sensory Nerve Conduction Velocity
Assessed via median sensory nerve conduction study. Unit of Measure: meters/second (m/s)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Sensory Distal Latency
Assessed via median sensory nerve conduction study. Unit of Measure: milliseconds (ms)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Motor Compound Muscle Action Potential Amplitude
Assessed via median motor nerve conduction study. Unit of Measure: millivolts (mV)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Motor Nerve Conduction Velocity
Assessed via median motor nerve conduction study. Unit of Measure: meters/second (m/s)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Motor Distal Latency
Assessed via median motor nerve conduction study. Unit of Measure: milliseconds (ms)
Time frame: Before treatment and 3 months after treatment completion
Change from Baseline in Median Nerve Cross-Sectional Area (Ultrasonography)
Median nerve cross-sectional area, transverse diameters, intraneural vascularity, echogenicity, and palmar bowing will be assessed by ultrasonography. Unit of Measure: square millimeters (mm²)
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in Grip Strength
Assessed using a Jamar hydraulic hand dynamometer, following American Society of Hand Therapists (ASHT) recommendations. The mean of three trials will be used. Unit of Measure: kilograms (kg)
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in Pinch Strength (Tip, Tripod, and Tip-to-Tip Pinch)
Assessed using a pinch gauge for tip pinch (lateral pinch), tripod pinch (3-jaw chuck), and tip-to-tip pinch. The mean of three trials for each pinch type will be used. Unit of Measure: kilograms (kg)
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in Pain (Visual Analog Scale)
Pain intensity will be assessed using a 0-10 cm Visual Analog Scale, with higher scores indicating greater pain intensity. Unit of Measure: score on a scale (0-10)
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Change from Baseline in QuickDASH Score
Upper extremity function will be assessed using the Turkish-validated QuickDASH questionnaire, with higher scores indicating greater disability. Unit of Measure: score on a scale (0-100)
Time frame: Before treatment, immediately after completing 15 sessions, and 3 months after treatment completion
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Sep 2026; primary completion for Feb 2027, 5 months later.
Of 251 non-industry interventional studies with no phase under Carpal Tunnel Syndrome, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 27. This study's planned 5 months is below that.
Counting every sponsor, half of 261 studies reached it within 12 months; a quarter within 7 and three quarters within 26.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Bursa Yuksek Ihtisas Training and Research Hospital