A Phase 1 interventional study of Bupivacaine injection in Postoperative Pain, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Ain Shams University · Phase 1, Interventional, and Prevention
Among 362 studies testing bupivacaine in Pain, Postoperative — 55 open to participants now, 58 under way, 5 of them phase 3. Bupivacaine · Pain, Postoperative.
Among the 362 studies testing bupivacaine in Pain, Postoperative, this one is the 308th largest by enrollment, is one of 26 that started in 2025, is one of 21 in phase 1, and was the 356th registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's enrollment of 30 is below the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →55 of the 362 studies testing bupivacaine in Pain, Postoperative are open now, in 8 countries. Each count lists the studies.
Bupivacaine: first FDA approval 1972 (MARCAINE HYDROCHLORIDE PRESERVATIVE FREE), first EMA approval 2020. What it is approved for, and how studies give it, is on its page →
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years to 70 Years · all sexes · no healthy volunteers.
The full table on the hub →362 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 26 started in 2025.
Median enrollment 70 across the 362 interventional studies. Of the 258 that completed or were terminated, 106 (41%) have results posted.
46 of 362 have an industry lead sponsor. The 10 most frequent:
Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
102 studies in Pain, Postoperative by Ain Shams University: 24 open now, 28 under way, 2 of them phase 3. Of 63 finished, 3 (5%) have results posted.
Among the 102 studies in Pain, Postoperative by Ain Shams University, this one is the 91st largest by enrollment of the 100 interventional ones, is one of 19 that started in 2025, is one of 14 in phase 1, and was the 99th registered.
Ain Shams University’s Pain, Postoperative studies by the year they started, since 2013.
21 of the studies testing bupivacaine in Pain, Postoperative that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06350981Phase 3Foundation for Orthopaedic Research and EducationAnalgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion | 2027-01-01 |
| NCT06077422Phase 3Rutgers, The State University of New JerseyExparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain | 2027-01-11 |
| NCT07650760Wah Medical college , POF hospitalComparison of Intraperitoneal Bupivacaine and Saline Irrigation for Pain Relief After Laparoscopic Cholecystectomy | 2026-12 |
| NCT03737292Milton S. Hershey Medical CenterLiposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy | 2026-12 |
| NCT02381353Mayo ClinicExparel Injection for Postoperative Orbital Pain | 2026-12 |
Among the 362 studies testing bupivacaine in Pain, Postoperative, from their registry updates:
Among Ain Shams University’s 102 in Pain, Postoperative:
The aim of the Study is to compare the analgesic efficacy and clinical outcomes of suprainguinal fascia iliaca block (SIFIB) alone versus SIFIB combined with sciatic nerve block (SNB) in patients undergoing hip surgery.
The aim of the Study is to compare the analgesic efficacy and clinical outcomes of suprainguinal fascia iliaca block (SIFIB) alone versus SIFIB combined with sciatic nerve block (SNB) in patients undergoing hip surgery.
Primary Objectives:
Time for first rescue analgesia.
Secondary Objectives:
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Age: 18 - 70 years old.
Exclusion Criteria:
Refusal to participate.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Bupivacaine injection
Drug: Bupivacaine injection
Bupivacaine injection
Time for first rescue analgesia
Time to first request for rescue analgesia: Defined as the time interval from the end of procedure until the patient's first complaint of pain with a Numerical Rating Scale (NRS) score ≥ 4 and requests pain relief
Time frame: Numerical Pain Score in PACU, 6 hrs, 12 hrs, 24 hrs and 48 hrs postoperative
Motor Block Assessment
Motor Block Assessment: Assessed using the Modified Bromage Scale (0 = no block; 1 = unable to raise extended leg; 2 = unable to flex knee; 3 = unable to move foot or knee) at 2, 6, 12, and 24 hours postoperatively
Time frame: The Modified Bromage Scale at 2 , 6 , 12 and 24 hours postoperatively
This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drug tested here: Bupivacaine