An interventional study of Speeded practice training and Arithmetic strategy training in Math Learning Disability, Learning Disabilities and Learning Disabilities, Child, sponsored by Stanford University. Not yet recruiting at 1 site in United States. Open to participants aged 6 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-24.
Sponsored by Stanford University · Not applicable, Interventional, and Treatment
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing and remediating weaknesses in arithmetic skills in children, including those with mathematical learning disabilities.
270 studies on the registry are indexed under Learning Disabilities; 62 are open to participants now.
This study's planned enrollment of 160 is above the median of 60 across 181 interventional studies indexed under Learning Disabilities.
Browse Learning Disabilities studies →Stanford University is the lead sponsor of 2,168 studies on the registry; 431 are open to participants now.
Of its 267 completed or terminated interventional studies of FDA-regulated products, 207 (78%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that progressively develop the efficient use of arithmetic problem-solving strategies. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Behavioral: Arithmetic strategy training
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that focus solely on enhancing arithmetic fluency. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Behavioral: Speeded practice training
Speeded practice training includes activities that focus solely on enhancing arithmetic fluency.
Arithmetic strategy training includes activities that progressively develop the efficient use of arithmetic problem-solving strategies.
Change from baseline in arithmetic task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on arithmetic task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in arithmetic task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on arithmetic task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of arithmetic task performance (drift rate)
Latent cognitive processing will be measured by drift rate from children's arithmetic task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of arithmetic performance (post-error adjustment)
Latent cognitive processing will be measured by post-error adjustment from children's arithmetic task performance
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in brain activation during arithmetic task performance
Neural activity will be measured during a functional magnetic resonance imaging arithmetic task. Data will consist of beta values from individual-subject contrast maps for the Small vs. Large contrast in the whole-brain general linear modeling functional magnetic resonance imaging analysis.
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in brain representation during arithmetic task performance
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of spatial correlations of voxel-wise brain activation between Trained vs. Rest and Untrained vs. Rest contrasts for individual subjects.
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in brain connectivity during arithmetic task performance
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of generalized psychophysiological interaction beta values from individual subject contrast maps for Small vs. Large contrast.
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in untrained arithmetic task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on untrained arithmetic task
Time frame: Baseline and post-intervention (after 6 weeks)
Change from baseline in untrained arithmetic task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on untrained arithmetic task
Time frame: Baseline and post-intervention (after 6 weeks)
Plan to share: No
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Start is estimated for Sep 2026; primary completion for Sep 2031, 60 months later.
Of 96 non-industry interventional studies with no phase under Learning Disabilities, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 53. This study's planned 60 months is above that.
Counting every sponsor, half of 99 studies reached it within 29 months; a quarter within 9 and three quarters within 51.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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