An observational study in Critical Illness, sponsored by Sohag University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-20.
Sponsored by Sohag University · Observational
Critical illness represents a complex pathophysiological state characterized by systemic inflammation, oxidative stress, immune dysregulation, and progressive multiorgan dysfunction. In the Intensive Care Unit (ICU) setting, accurate and timely risk stratification remains paramount for optimizing patient outcomes, guiding therapeutic decision-making, and ensuring appropriate allocation of limited healthcare resources .Red cell distribution width (RDW), a quantitative measure of anisocytosis, has emerged as a powerful independent predictor of adverse outcomes across diverse clinical contexts, including sepsis, cardiovascular disease, and general ICU populations . Elevated RDW reflects dysregulated erythropoiesis and is mechanistically linked to chronic inflammation, oxidative stress, nutritional deficiencies, and impaired hematopoietic progenitor cell function .Mean corpuscular hemoglobin concentration (MCHC) represents the average hemoglobin concentration within erythrocytes and provides valuable information regarding red blood cell integrity, hemoglobin synthesis, and oxygen-carrying capacity. Reduced MCHC values are observed in conditions associated with impaired hemoglobin production, while elevated values may indicate hemolysis or red cell dehydration .Emerging evidence suggests that composite hematological ratios may enhance predictive performance compared to individual parameters by integrating complementary physiological information. The RDW:MCHC ratio is a novel biomarker that combines variability in red cell size with hemoglobin concentration, potentially offering a more comprehensive reflection of the underlying pathophysiological derangements characteristic of critical illness
All consecutive adult patients (≥18 years) admitted to the Intensive Care Unit (ICU) at Sohag University Hospital, a tertiary care referral hospital, who meet the eligibility criteria. The study population includes both obstetric (pregnant and postpartum) and non-obstetric (non-pregnant) critically ill patients. Patients with documented hematological malignancies or recent blood transfusion (within 7 days prior to ICU admission) are excluded.
ICU stay of at least 24 hours duration
Available complete blood count (CBC) parameters at the time
Exclusion Criteria:
Documented hematological malignancies (including leukemia, lymphoma, and myelodysplastic syndromes)
1. ICU Mortality
All-cause mortality during ICU stay, assessed through prospective follow-up from admission until discharge or death
Time frame: From ICU admission to ICU discharge or death, up to 90 days
ICU Length of Stay
Duration of intensive care unit admission measured in days from ICU admission until ICU discharge.
Time frame: From ICU admission to ICU discharge (assessed up to 90 days)
Plan to share: No
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This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Sohag University