An interventional study of fasting periods of 24 hours and fasting periods of 48 hours in Esophageal Varices, sponsored by The First Affiliated Hospital of Zhengzhou University. Recruiting at 12 sites in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by The First Affiliated Hospital of Zhengzhou University · Not applicable, Interventional, and Treatment
To evaluate the efficacy and safety of early postoperative oral intake (with a fasting period of 6 hours) versus delayed postoperative oral intake (with fasting periods of 24 hours or 48 hours) in patients with cirrhosis undergoing esophageal variceal ligation therapy.
150 studies on the registry are indexed under Esophageal and Gastric Varices; 39 are open to participants now.
This study's planned enrollment of 339 is above the median of 110 across 96 interventional studies indexed under Esophageal and Gastric Varices.
Browse Esophageal and Gastric Varices studies →The First Affiliated Hospital of Zhengzhou University is the lead sponsor of 126 studies on the registry; 73 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
-1. The patient must be aged>18 years; 2. The diagnosis of portal hypertension must be confirmed, with gastroscopy revealing severe esophageal varices and a positive red sign; 3. For patients undergoing endoscopic variceal ligation (EVL) due to esophageal varices (including those with hemorrhage or those eligible for elective ligation), successful intraoperative ligation is achieved (achieving hemostasis or completing the predetermined ligation procedure).
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A score of how well the liver works in people with liver disease such as cirrhosis: class A is mild, B moderate and C severe.
A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.
Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Child-Pugh class
A score of how well the liver works in people with liver disease such as cirrhosis: class A is mild, B moderate and C severe.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Bilirubin
A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.
Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Post-banding surgery: fasting for 6 hours. Postoperatively, during the first 6-24 hours: liquid diet; initial dose: 10-50 mL; subsequent doses: 50-250 mL each time, administered every 3 hours; total fluid intake over 24 hours should not exceed 1,000 mL; intravenous fluid replacement should be 1,000-1,500 mL. On postoperative days 2-3: liquid diet with small, frequent meals (if no adverse events occur within the first day postoperatively, such as hematemesis, vomiting, dysphagia, or fever); on postoperative days 4-7: semi-liquid or soft diet; starting from postoperative day 8: gradual transition to a regular diet.
Other: fasting periods of 6 hours
After ligation surgery, fasting for 24 hours is required, with only intravenous fluid support (2,000-2,500 mL/day); Days 2-3 postoperatively: liquid diet; Days 4-7 postoperatively: semi-liquid or soft diet; Starting from day 8 postoperatively: gradual transition to a regular diet.
Other: fasting periods of 24 hours
Post-balloon occlusion procedure: fasting for 48 hours; intravenous fluid support only (2,000-2,500 mL/day); Day 3 post-procedure: liquid diet; Days 4-7 post-procedure: semi-liquid or soft diet; Starting from Day 8 post-procedure: gradual transition to a regular diet.
Other: fasting periods of 48 hours
Post-balloon occlusion procedure: fasting for 24 hours
Post-balloon occlusion procedure: fasting for 48 hours
Post-balloon occlusion procedure: fasting for 6 hours
Rate of early postoperative rebleeding
Time frame: Week 0-6
Length of hospital stay
Time frame: Week 0-4
nutritional status
Time frame: Week 0-4
incidence of non-hemorrhagic adverse events
Time frame: Week 0-4
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