CompletedNCT07767669Updated Aug 17, 2026

A Controlled Study to Evaluate the Effects of a Topical Cream on Symptoms of Arthritis, Joint, and Muscle Pain

An interventional study of Intervention (Saje Pain Release Joint & Arthritis Cream) and Placebo Comparator in Arthritis, Joint Pain and Muscle Pain, sponsored by Saie Beauty. Completed at 1 site in United States. Open to participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-17.

Sponsored by Saie Beauty · Not applicable, Interventional, and Treatment

Phase: Not applicable
Study type: Interventional
Enrollment: 80
Allocation: Randomized
Ages: 20 Years to 65 Years
Sex: All

Study summary

This is a randomized, triple-blind, controlled clinical trial evaluating the effects of Saje Pain Release Joint \& Arthritis Cream on symptoms of arthritis, joint pain, and muscle pain in adults aged 20-65. The trial is conducted virtually over seven days, with 80 participants randomized equally into an intervention arm (active topical cream) and a control arm (matched control product).

Participants apply their assigned product three times daily to affected areas (knees, elbows, wrists, or ankles) and complete questionnaires at Baseline, 30 minutes after the first application, and at the end of Day 7. The primary objective is to assess changes in arthritis and musculoskeletal pain symptoms, while secondary objectives assess participants' perceptions of joint pain, stiffness, function, comfort, flexibility, mobility, and overall quality of life.

Conditions studied

Arthritis
Joint Pain
Muscle Pain
Musculoskeletal Pain
Joint Stiffness

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Who can participate

Ages eligible: 20 Years to 65 Years
Sexes eligible: All
Accepts healthy volunteers: No

Inclusion criteria

Be male or female
Be aged 20-65
Has experienced issues regarding all of the following in the past four weeks: symptoms of arthritis of the knees, elbows, wrists, or ankles
joint pain and stiffness
Self-reported issues must be at least 3 out of 10 in severity, with 1 being the least severe and 10 being the most
Generally healthy - does not live with any uncontrolled chronic disease
If taking oral over-the-counter supplements or herbal remedies targeted at symptoms of arthritis, joint and muscle pain, has been consistently taking these for at least 3 months prior to starting the study, and is willing to maintain this routine for the study duration
Willing to avoid introducing any new forms of prescription medication or supplements that target symptoms of arthritis, joint and muscle pain for the study duration
Resides in the United States
Willing to maintain their current diet, sleep pattern, and activity levels for the duration of the trial

Exclusion criteria

Exclusion Criteria:

Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
Anyone with any allergies or sensitivities to any of the study product ingredients
Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
Symptoms occurring in a joint that has been surgically repaired
Anyone unwilling to follow the study protocol
Anyone who identifies as having sensitive skin
Anyone with any history of skin cancer or any pre-cancerous lesions on their skin
Anyone with a history of substance abuse
Anyone who is currently a smoker or has been a smoker in the past 3 months
Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration
Anyone with chronic skin conditions (e.g., dermatitis, eczema, psoriasis)
Anyone who currently takes prescription pain relief to manage their symptoms

Study design

Phase: Not applicable
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Single group
Masking: Triple (Participant, Investigator, Outcomes assessor)
Enrollment: 80 participants (actual)

Study arms

Experimental
Intervention (Saje Pain Release Joint & Arthritis Cream)
Dietary Supplement: Intervention (Saje Pain Release Joint & Arthritis Cream)
Placebo comparator
Placebo Comparator
Dietary Supplement: Placebo Comparator

Interventions

Dietary supplementIntervention (Saje Pain Release Joint & Arthritis Cream)
40 participants apply a thin layer of the Saje Pain Release Joint \& Arthritis Cream to arthritis-affected areas (knees, elbows, wrists, ankles) three times daily (morning, afternoon, and evening) for seven days
Dietary supplementPlacebo Comparator
40 participants apply a matched control product (identical in appearance and consistency to the active product but without active ingredients such as L-menthol and balsam copaiba oil) to arthritis-affected areas three times daily (morning, afternoon, and evening) for seven days

What researchers measure

Primary outcomes

Change in symptoms of arthritis
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in symptoms of joint pain
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in symptoms of muscle pain
Assessed via self-reported numerical pain rating scale and the Musculoskeletal Health Questionnaire (MSK-HQ) validated questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7

Secondary outcomes

Change in self-reported joint pain
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint stiffness
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint function
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported joint comfort
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported flexibility
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported mobility
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported quality of life
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7
Change in self-reported overall health
Assessed via self-reported questionnaire
Time frame: Baseline, 30 minutes after first application, and Day 7

Study locations

1 site

Citruslabs
Las Vegas, Nevada 89101, United States

Registry details

Key details

Study ID: NCT07767669
Lead sponsor: Saie Beauty
Collaborators: Citruslabs
Responsible party: Sponsor
First posted: Aug 17, 2026
Start date: Feb 1, 2026
Primary completion: May 31, 2026
Completion: May 31, 2026
Last update: Aug 17, 2026

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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