An interventional study of Gel foam and Thymoquinone gel + gel foam in Radiographic Evaluation, Bone Density and Bone Width, sponsored by Kafrelsheikh University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-08-14.
Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Treatment
This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.
Tooth extraction triggers a cascade of biological events which lead to significant remodeling of the alveolar ridge, frequently resulting in reductions in both bone width and height.
The concept of alveolar ridge preservation (ARP) has developed to address the bone resorption that follows extraction. ARP aims to maintain ridge dimensions and reduce the need for further augmentation before implant placement.
Among these, the small-molecule Thymoquinone (TQ), derived from Nigella sativa, has demonstrated significant osteogenic, anti-inflammatory, and antioxidant effects in preclinical studies.
Kafrelsheikh University is the lead sponsor of 294 studies on the registry; 114 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Patients will receive gel foam only
Drug: Gel foam
Patients will receive 0.2% thymoquinone gel + gel foam.
Drug: Thymoquinone gel + gel foam
Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.
Drug: Nano-formulated 0.2% thymoquinone gel + gel foam
Patients will receive gel foam only.
Drug page: Thymoquinone
Patients will receive 0.2% thymoquinone gel + gel foam.
Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.
Change in alveolar bone density after tooth extraction
Alveolar bone density will be assessed radiographically using cone-beam computed tomography (CBCT). The change in bone density from baseline to the specified postoperative assessment will be compared.
Time frame: 3 months after tooth extraction
Change in alveolar bone width after tooth extraction
Alveolar bone width will be assessed radiographically using cone-beam computed tomography (CBCT). The change in alveolar ridge width from baseline to the postoperative assessment will be measured.
Time frame: 3 months after tooth extraction
Change in alveolar ridge dimension after tooth extraction
Alveolar ridge dimensions will be assessed radiographically using cone-beam computed tomography (CBCT). Changes in the dimensions of the alveolar ridge following tooth extraction will be measured and compared.
Time frame: 3 months after tooth extraction
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
Time frame: After the end of study for one year.
Access criteria: The data will be available upon a reasonable request from the corresponding author
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Studies of the drug tested here: Thymoquinone