An interventional study of Cold snare endoscopic mucosal resection (CS-EMR) and Hot snare endoscopic mucosal resection (HS-EMR) in Colorectal Polyps and Endoscopic Mucosal Resection, sponsored by Nanfang Hospital, Southern Medical University. Not yet recruiting. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-08-13.
Sponsored by Nanfang Hospital, Southern Medical University · Not applicable, Interventional, and Treatment
This multicenter, prospective, randomized, non-inferiority trial aimed to compare the efficacy and safety of cold snare endoscopic mucosal resection (CS-EMR) and hot snare endoscopic mucosal resection (HS-EMR) for resection of intermediate-size (10-20 mm) flat nonpedunculated colorectal polyps.
312 studies on the registry are indexed under Polyps; 60 are open to participants now.
This study's planned enrollment of 968 is above the median of 150 across 204 interventional studies indexed under Polyps.
Browse Polyps studies →Nanfang Hospital, Southern Medical University is the lead sponsor of 490 studies on the registry; 214 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Eligible colorectal polyps measuring 10-20 mm will be resected using CS-EMR.
Procedure: Cold snare endoscopic mucosal resection (CS-EMR)
Eligible colorectal polyps measuring 10-20 mm will be resected using HS-EMR.
Procedure: Hot snare endoscopic mucosal resection (HS-EMR)
During CS-EMR, methylene blue-stained epinephrine saline is injected into the submucosa surrounding the lesion to achieve submucosal lifting. The polyp together with 1-2 mm of adjacent mucosa is subsequently tightly snared and mechanically transected.
During HS-EMR, methylene blue-stained epinephrine saline is injected into the submucosa surrounding the lesion to achieve submucosal lifting. The snare is positioned around the lesion, and electrocautery is delivered via the electrosurgical generator for transection.
complete resection rate
All five biopsy specimens harvested from the resection margins after EMR resection yielded negative pathological findings. These five biopsy samples consisted of four specimens collected from the four quadrants of the resection wound margin and one specimen obtained from the wound base.
Time frame: Within 14 days
en bloc resection rate
The lesion was completely excised under endoscope and a single specimen was obtained.
Time frame: Within one days
Unresectable rate of CS-EMR
A resection procedure that needed high-frequency electric current.
Time frame: Within one day
Intraprocedural bleeding
Intraoperative arterial bleeding or active mucosal oozing lasting more than 30 seconds that requires endoscopic hemostatic intervention.
Time frame: Within one day
Intraprocedural perforation
Endoscopic observation of perforation requiring sealing with clips
Time frame: Within one day
Procedural time
The duration from the first occurrence of injection needle under endoscope visual field to complete removal of the resected polyp
Time frame: Within one day
Delayed bleeding
haemorrhage after colonoscopy requiring endoscopic haemostasis with 14 days.
Time frame: Within 14 days
Delayed perforation
Any perforation within 14 days
Time frame: Within 14 days
Number of clips used
The number of clips used for each resected polyp
Time frame: Within one day
No study locations are listed for this record.
Start is estimated for Aug 2026; primary completion for Oct 2028, 26 months later.
Of 68 non-industry interventional studies with no phase under Polyps, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 42. This study's planned 26 months is above that.
Counting every sponsor, half of 79 studies reached it within 23 months; a quarter within 12 and three quarters within 42.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Nanfang Hospital, Southern Medical University →