A Clinical Trial to Evaluate the Efficacy and Safety of HL-1186 Tablet in the Treatment of Postherpetic Neuralgia

1. Aged ≥ 18 years, of either sex.
2. Pain persists for 1 month or more after healing of skin lesions in patients with herpes zoster.
3. Participants fully understand the purpose, characteristics, methods of the trial and possible AEs, voluntarily participate in the trial and sign the ICF, or have their legal guardian sign the ICF on their behalf.

Exclusion Criteria:

1. Participants with any pain other than PHN, or with other diseases that the researcher considers to potentially affect the evaluation of PHN.
2. Participants who may be allergic to the active ingredients or excipients of HL-1186 Tablet, HL-1186 Tablet placebo, pregabalin capsule or pregabalin capsule placebo, have an allergic constitution, or have a history of allergies to ≥ 3 substances.
3. Participants who have used drugs that may damage nerves (such as tumor chemotherapy drugs) after being diagnosed with PHN.
4. The baseline NRS collection begins within the 5 half-lives following the last use of the prohibited drug.
5. Participants who have previously used pregabalin with inadequate efficacy or intolerance.
6. Clinically significant abnormalities in the 12-lead electrocardiogram (ECG) during the screening period, or complicated with severe cardiopulmonary diseases, which are deemed unsuitable for inclusion by the researcher.
7. Participants with a history of malignant tumors within 2 years prior to screening.
8. Participants who have undergone major surgery within 8 weeks prior to enrollment or plan to undergo any surgery during the trial period.
9. Participants with positive human immunodeficiency virus antibody, positive syphilis serological test, positive hepatitis B virus surface antigen with hepatitis B virus DNA > ULN, or positive hepatitis C virus antibody with hepatitis C virus RNA > ULN.
10. Participants with a history of alcoholism or drug abuse within 2 years before screening.
11. Female participants who are pregnant, breastfeeding (within 1 year after delivery), or with a positive pregnancy test.
12. Participants deemed by the investigator to be unsuitable for participating in this trial for any reason.