An interventional study of PENG and Fascia iliaca in Anesthesia, Local, sponsored by Ain Shams University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Ain Shams University · Not applicable, Interventional, and Treatment
Hip fracture is a common orthopedic emergency in the elderly, and it is associated with significant morbidity and mortality. Surgical reduction and fixation are the definitive treatment in most patients, effective perioperative analgesia that minimizes the need for opioids and related adverse effects (such as delirium) is essential in this patient population.
In this study we are going to compare the effects of ultrasound guided pericapsular nerve group (PENG) block and suprainguinal fascia iliaca compartment block (FICB) on postoperative analgesia and quadriceps strength following total hip arthroplasty.
Total hip replacements (THRs) are quite successful surgery for many end-stage hip diseases in terms of pain relief and functional recovery (Lindberg-larsen M et al,2020). However, THR are associated with severe perioperative pain which prolongs length of hospitalization and increases the morbidity and medical cost (Guarino AJ et al,2019). Adequate pain management is crucial for improving the satisfaction of patients and clinical outcomes. Numerous strategies have been implemented to reduce postoperative pain following THR including local infiltration analgesia, epidural analgesia, intravenous non-steroidal anti-inflammatory agents and peripheral nerve block. (Kuchalik J et al,2017).
So, multimodal analgesia has been extensively used in perioperative period of THR (Berninger MT etal, 2019).
One of the regional anesthesia options for hip surgery is the fascia iliaca compartment block (FICB) that affects nerves important for hip innervation and sensory innervation of the thigh - femoral, obturator and lateral femoral cutaneous nerve.(Standring S,2015). FICB can be easily performed and is often a good solution for management of hip fractures in emergency departments. Its use reduces morphine pre-operative requirement for patients with femoral neck fractures and can also be indicated for hip arthroplasty, hip arthroscopy and burn management of the region (Madabushi R, 2016). A suprainguinal FICB produces a more complete sensory block of the medial, anterior and lateral region of the thigh when compared to infra-inguinal FICB. Additionally,supra-inguinal FICB leads to a more consistent spread in the cranial direction, thus spreading the anesthetic more consistently towards the lumbar plexus and three targeted nerves. So,the supra-inguinal approach has a superior postoperative analgesic efficacy compared to infra-inguinal approach along with significantly less morphine consumption in the first 24(Garner M,2017).
The pericapsular nerve group (PENG) block, which targets sensory branches of the obturator, accessory obturator, and femoral nerves in the anterior capsule of the hip, has been proposed as an effective method to treat pain associated with hip fractures and total hip arthroplasty(THA)(Giron-Arango L,2018). The PENG block provides coverage of the sensory nerves supplying the anterior hip while sparing motor blockade of the quadriceps; a known complication of fascia iliaca and femoral blocks (Tran J,2019).
PENG block has potential advantages over traditional forms of regional analgesia for pain originating from the hip, such as femoral nerve or fascia iliaca blocks. One of these potential advantages include a wider and more complete coverage of sensory nerves innervating the hip, leading to more effective regional analgesia with the potential to reduce postoperative pain,increase patient satisfaction and allow early mobilization(Bartels K,2016).
Ain Shams University is the lead sponsor of 1,953 studies on the registry; 430 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
patients receiving Peng block.
Procedure: PENG
patients receiving suprainguinal Fascia iliaca block.
Procedure: Fascia iliaca
patients receiving Peng block.
patients receiving suprainguinal Fascia iliaca block
pain score(VAS score)
The primary outcome measure was pain scores(VAS score) from 0(no pain) till 10 severe pain
Time frame: 24 hour
Started Jan 2022 (actual). Primary completion is estimated for Dec 2027, 71 months after the start.
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