An interventional study of Minimally Invasive Non-Surgical Therapy (MINST) and Conventional Scaling and Root Planing in Periodontitis and Periodontitis (Stage 3), sponsored by Ataturk University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-08-10.
Sponsored by Ataturk University · Not applicable, Interventional, and Treatment
This single-center, split-mouth, randomized controlled clinical trial aims to evaluate the clinical effectiveness of Minimally Invasive Non-Surgical Therapy (MINST) as an adjunct to conventional non-surgical periodontal therapy in patients with Stage III/IV periodontitis. Twenty-three systemically healthy adults presenting with bilateral molar teeth exhibiting periodontal pockets ≥5 mm with bleeding on probing will be enrolled. In each participant, molar teeth will be randomly allocated to receive either conventional subgingival scaling and root planing (SRP) using ultrasonic instruments alone (control) or conventional SRP followed by MINST using Mini-Five Gracey curettes under magnification loupes (test). Clinical periodontal parameters, including Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL), will be evaluated at baseline, 3 months, and 6 months after treatment. The study will investigate whether MINST provides superior clinical outcomes compared with conventional non-surgical periodontal therapy.
Periodontitis is a chronic inflammatory disease characterized by the destruction of the tooth-supporting tissues. Conventional non-surgical periodontal therapy based on scaling and root planing (SRP) is considered the first-line treatment for periodontal pockets. However, complete removal of subgingival biofilm and calculus may be difficult in deep pockets, furcation areas, and root concavities because of limited access.
Minimally Invasive Non-Surgical Therapy (MINST) has been introduced to improve access to deep periodontal defects while minimizing soft tissue trauma. The technique combines magnification loupes with Mini-Five Gracey curettes to allow more precise instrumentation and preservation of soft tissues during periodontal debridement.
This prospective, single-center, split-mouth randomized controlled clinical trial will include 23 patients diagnosed with Stage III/IV periodontitis. Bilateral molar teeth with probing pocket depth ≥5 mm and bleeding on probing will be randomly assigned to either the test or control intervention within each participant.
The control sites will receive conventional subgingival scaling and root planing using ultrasonic instruments. The test sites will receive conventional ultrasonic instrumentation followed by MINST performed with Mini-Five Gracey curettes under magnification loupes.
All participants will receive oral hygiene instructions and full-mouth supragingival periodontal therapy before subgingival treatment. Scaling and root planing will be completed over two treatment sessions separated by one week. Professional supportive periodontal therapy will be provided during follow-up according to the study protocol.
Clinical evaluations will be performed at baseline, 3 months, and 6 months. The primary clinical variables include Plaque Index (PI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL). Microbiological evaluation using the benzoyl-DL-arginine naphthylamide (BANA) assay will also be performed at the same follow-up intervals.
The objective of the study is to determine whether MINST provides improved clinical periodontal outcomes compared with conventional non-surgical periodontal therapy in molar teeth affected by Stage III/IV periodontitis.
1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.
This study's planned enrollment of 23 is below the median of 44 across 846 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Ataturk University is the lead sponsor of 458 studies on the registry; 124 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants assigned to the experimental arm will receive conventional non-surgical periodontal therapy with ultrasonic scaling and root planing followed by Minimally Invasive Non-Surgical Therapy (MINST) using Mini-Five Gracey curettes under magnification loupes. Treatment will be performed over two sessions separated by one week.
Procedure: Minimally Invasive Non-Surgical Therapy (MINST)
Participants assigned to the control arm will receive conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing using ultrasonic instruments. Treatment will be performed over two sessions separated by one week.
Procedure: Conventional Scaling and Root Planing
Minimally Invasive Non-Surgical Therapy (MINST) consists of subgingival scaling and root planing performed using Mini-Five Gracey curettes under ×4.0 magnification loupes following conventional ultrasonic instrumentation. The procedure is designed to minimize soft tissue trauma while improving access to deep periodontal pockets and root surface debridement. Treatment is completed in two sessions separated by one week.
Conventional non-surgical periodontal therapy consisting of subgingival scaling and root planing performed using ultrasonic instruments. Treatment is completed over two sessions separated by one week according to the study protocol.
Also known as: SRP
Probing Pocket Depth (PPD)
Change in probing pocket depth (PPD) measured in millimeters using a UNC-15 periodontal probe.
Time frame: Baseline, 3 months, and 6 months
Clinical Attachment Level (CAL)
Change in clinical attachment level (CAL) measured in millimeters using a UNC-15 periodontal probe.
Time frame: Baseline, 3 months, and 6 months
Bleeding on Probing (BOP)
Change in bleeding on probing (BOP).
Time frame: Baseline, 3 months, and 6 months
Plaque Index (PI)
Change in Plaque Index (PI).
Time frame: Baseline, 3 months, and 6 months
BANA Test
Changes in subgingival microbial profile assessed using the benzoyl-DL-arginine naphthylamide (BANA) assay.
Time frame: Baseline, 3 months, and 6 months
Plan to share: No
Start is estimated for Aug 2026; primary completion for Jan 2027, 5 months later.
Of 480 non-industry interventional studies with no phase under Periodontitis, half reached primary completion within 15 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 31. This study's planned 5 months is below that.
Counting every sponsor, half of 494 studies reached it within 16 months; a quarter within 8 and three quarters within 31.
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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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