An interventional study of Adaptive Computerized Cognitive Training and Adaptive Computerized Cognitive Training in Cognitive Dysfunction, Cognitive Disorder and Cognitive Training, sponsored by China Medical University, China. Not yet recruiting at 1 site in China. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by China Medical University, China · Not applicable, Interventional, and Treatment
This study aims to evaluate the effectiveness of adaptive computerized cognitive training (CCT) in improving cognitive function among community-dwelling older adults with mild cognitive impairment (MCI) and to compare the maintenance effects of different training frequencies after the initial intervention. A quasi-experimental study will be conducted in three communities in Shenyang, Liaoning Province, China. All participants will receive a 12-week adaptive CCT program. Participants will be assigned to either a high-frequency maintenance training group or a training discontinuation group. Cognitive assessments will be performed at baseline, immediately after the intervention, and during follow-up. The primary outcome is global cognitive function, while secondary outcomes include memory, attention, executive function, language, visuospatial ability, and activities of daily living. The findings of this study are expected to provide evidence for optimizing computerized cognitive training programs and long-term management strategies for older adults with MCI in community settings.
With the rapid aging of the global population, mild cognitive impairment (MCI) has become a critical stage for dementia prevention and early intervention. Cognitive training is recognized as one of the most effective non-pharmacological interventions for individuals with MCI. Among various approaches, adaptive computerized cognitive training (CCT) can dynamically adjust task difficulty according to an individual's performance, thereby improving training personalization, engagement, and adherence. However, evidence regarding the optimal maintenance training frequency and the long-term sustainability of cognitive benefits remains limited.
This study adopts a quasi-experimental design and will recruit community-dwelling adults aged 60 years and older with MCI from three communities in Shenyang, Liaoning Province, China. All participants will complete a 12-week adaptive computerized cognitive training program using the Heling Brain Planet WeChat mini-program, with training sessions lasting 30 minutes, three times per week. After the initial intervention, participants will be assigned to either a high-frequency maintenance training group, which will continue training three times per week, or a training discontinuation group, which will receive routine community health management only. Follow-up cognitive assessments will be conducted after the intervention and during the follow-up period.
The primary outcome will be global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes will include memory (Auditory Verbal Learning Test, AVLT), attention (Trail Making Test Part A, TMT-A), executive function (Stroop Color-Word Test), language (Boston Naming Test, BNT), visuospatial ability (Clock Drawing Test, CDT), and activities of daily living (ADL). The effects of different maintenance training frequencies on cognitive improvement and the persistence of intervention benefits will be compared.
This study is expected to evaluate the effectiveness of adaptive computerized cognitive training for improving cognitive function in community-dwelling older adults with MCI and to determine whether continued maintenance training can prolong cognitive benefits. The findings will provide evidence for optimizing community-based digital cognitive training programs and developing sustainable intervention strategies for the long-term management of older adults with MCI.
3,872 studies on the registry are indexed under Cognitive Dysfunction; 1,119 are open to participants now.
This study's planned enrollment of 36 is below the median of 64 across 2,794 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →China Medical University, China is the lead sponsor of 94 studies on the registry; 34 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive adaptive computerized cognitive training using the Heling Brain Planet WeChat mini-program. During the initial intervention phase, participants will complete training sessions three times per week for 30 minutes per session over 12 weeks. After the initial intervention, participants will continue maintenance training three times per week until the end of the follow-up period. The training program automatically adjusts task difficulty according to individual performance and includes exercises targeting attention, memory, executive function, language, visuospatial ability, and other cognitive domains.
Behavioral: Adaptive Computerized Cognitive Training
Participants will receive the same 12-week adaptive computerized cognitive training program during the initial intervention phase. After completing the initial intervention, no further computerized cognitive training will be provided. Participants will continue to receive routine community health management and will complete follow-up cognitive assessments according to the study schedule.
Behavioral: Adaptive Computerized Cognitive Training
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants choose to continue training receive maintenance adaptive computerized cognitive training.
Participants receive adaptive computerized cognitive training delivered through the Heling Brain Planet WeChat mini- program. The intervention consists of individualized cognitive exercises targeting multiple cognitive domains, including attention, memory, executive function, language, visuospatial ability, perceptual-motor function, and social cognition. The training difficulty is automatically adjusted according to each participant's performance to provide personalized cognitive stimulation. During the initial intervention phase, all participants complete 30-minute training sessions three times per week for 3 months. After the initial intervention, participants not to continue discontinue the intervention and undergo follow-up assessments only.
Change in global cognitive function assessed by the Montreal Cognitive Assessment (MoCA)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in cognitive function assessed by the Mini-Mental State Examination (MMSE)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in language function assessed by the Boston Naming Test (BNT)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in attention assessed by the Trail Making Test Part A (TMT-A)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in executive function assessed by the Stroop Color-Word Test
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in visuospatial function assessed by the Clock Drawing Test (CDT)
Time frame: Baseline, Month 3, Month 4, and Month 6
Change in activities of daily living assessed by the Activities of Daily Living (ADL) scale
Time frame: Baseline, Month 3, Month 4, and Month 6
Plan to share: Undecided
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China Medical University, China