An interventional study of All participants will receive MINST in Controlled Type 2 Diabetic Patients With Periodontitis, sponsored by Cairo University. Not yet recruiting. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-11.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
The present randomized placebo-controlled trial aims to evaluate and compare the clinical and radiographic efficacy of subgingivally delivered 0.05% zoledronate gel and 1% metformin gel as adjuncts to minimally invasive nonsurgical treatment of intrabony defects in patients with controlled type 2 diabetes mellitus and periodontitis.
10,371 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,406 are open to participants now.
This study's planned enrollment of 30 is below the median of 80 across 8,350 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
MINST will be performed followed by Subgingival administration of 0.05% zoledronate gel
Procedure: All participants will receive MINST
MINST will be performed followed by Subgingival administration of 1% metformin gel
Procedure: All participants will receive MINST
MINST will be performed followed by Subgingival administration of placebo gel
Procedure: All participants will receive MINST
using ultrasonic scalers and hand curettes over two sessions within 1 week.
Radiographic intra-bony defect depth
The radiographic IBD depth will be measured by computer-aided software program, IBD depth will be measured on the radiograph by measuring the vertical distance from the crest of the alveolar bone to the base of the defect
Time frame: 6 months
Clinical attachment level
measured from the cementoenamel junction (CEJ) to the bottom of pocket.
Time frame: 6 months
Periodontal pocket depth (PPD)
will be recorded from the gingival margin to the base of the pocket
Time frame: 6 months
No study locations are listed for this record.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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