An interventional study of Probing depth reduction in Periodontitis, sponsored by University of Catania. Recruiting at 1 site in Italy. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-07-31.
Sponsored by University of Catania · Not applicable, Interventional, and Treatment
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on targeted metabolomics in gingival crevicular fluid
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment in subjects with periodontitis.
All the 60 patients with periodontitis are assessed for clinical, periodontal, and gingival crevicular fluid following of minimally invasive approach MINST or Q-SI (quadrantwise).
Measurements are taken before and after initial periodontal treatment in the periodontal subjects.
1,231 studies on the registry are indexed under Periodontitis; 295 are open to participants now.
This study's planned enrollment of 60 is above the median of 44 across 846 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →University of Catania is the lead sponsor of 71 studies on the registry; 15 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Periodontitis patients treated by means of MINST. Patients were treated with non-surgical MINST periodontal treatment in a single session.
Other: Probing depth reduction
Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week.
Other: Probing depth reduction
Probing depth reduction in millimetres before and after treatment
Probing pocket depth
Reduction in Probing Pocket Depth after treatment
Time frame: 6 months
Plan to share: Yes — Study results
Supporting information: Study protocol
Time frame: 1 year
Access criteria: Pubmed
Data sharing details ↗ · pubmed.ncbi.nlm.nih.gov
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University of Catania